Testing the effects of mass drug administration of azithromycin on mortality and other outcomes among 1 –11-month-old infants in Mali (LAKANA): study protocol for a cluster-randomized, placebo-controlled, double-blinded, parallel-group, three-arm clinical trial
DiscussionIf LAKANA provides evidence in support of a positive mortality benefit resulting from azithromycin MDA, it will significantly contribute to the options for successfully promoting child survival in Mali, and elsewhere in sub-Saharan Africa.Trial registrationClinicalTrials.gov NCT04424511. Registered on 11 June 2020. (Source: Trials)
Source: Trials - January 3, 2023 Category: Research Source Type: clinical trials
Safety, effectiveness, and adherence of a short and all-oral treatment regimen for the treatment of rifampicin-resistant tuberculosis in Niger: a study protocol of a pragmatic randomised clinical trial with stratified block randomisation
DiscussionTo increase the feasibility of conducting a RCT, embedded in routine activities of all Niger ’s RR-TB Units, we used a creative trial design. We randomised by monthly blocks, whereby the regimen used changes every month, using the month of RR-TB diagnosis as stratifying variable. This approach was deemed feasible for Niger's national tuberculosis programme, as it simplifies the work of th e clinicians running the RR-TB units. Our creative design may serve as an example for other national programs. Findings will inform national and international RR-TB treatment guidelines, and will also strengthen the evidence-b...
Source: Trials - December 13, 2022 Category: Research Source Type: clinical trials
Acceptability of a Microbiome-directed Food in Young Children With Acute Malnutrition
Condition: Malnutrition, Child Interventions: Dietary Supplement: MDF then RUTF/RUSF; Dietary Supplement: RUTF/RUSF then MDF Sponsors: Epicentre; Epicentre, Niger; National Nutrition Direction, Niger; Ministry of Public Health and Social Affairs, Niger; Regional Direction of Public Health, Maradi Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 23, 2022 Category: Research Source Type: clinical trials
