A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial
AbstractObjectivesThe pathophysiology of SARS-Cov-2 is characterized by inflammation, immune dysregulation, coagulopathy, and endothelial dysfunction. No single therapeutic agent can target all these pathophysiologic substrates. Moreover, the current therapies are not fully effective in reducing mortality in moderate and severe disease. Hence, we aim to evaluate the combination of drugs (aspirin, atorvastatin, and nicorandil) with anti-inflammatory, antithrombotic, immunomodulatory, and vasodilator properties as adjuvant therapy in covid- 19.Trial designSingle-centre, prospective, two-arm parallel design, open-label random...
Source: Trials - July 15, 2021 Category: Research Source Type: clinical trials

Comparative Bioavailability Study of Oral Edaravone Administered Orally and Via a Nasogastric Tube
Condition:   Healthy Adult Subjects Intervention:   Drug: MT-1186 Sponsor:   Mitsubishi Tanabe Pharma Corporation Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2021 Category: Research Source Type: clinical trials

Effect of Evidence-Based Skin Care and Hydrocolloid Dressing in the Prevention of Nasogastric-Related Pressure Injury
Conditions:   Medical Device Site Injury;   Nasogastric Tube;   Pressure Injury Interventions:   Other: skin care arm of where evidence-based practices in the implementation guide;   Device: hydrocolloid (Convatec Granuflex-extra thin) dressing;   Other: control Sponsors:   MAİDE YEŞİLYURT;   Necmettin Erbakan University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 24, 2020 Category: Research Source Type: clinical trials