Myeloproliferative Disorders Clinical Trials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms
Conditions: Polycythemia Vera; Essential Thrombocythemia; Prefibrotic/Early Primary Myelofibrosis; JAK2 V617F; High-risk Patients Interventions: Drug: Direct Oral Anticoagulants; Drug: Low-dose aspirin Sponsor: University Hospital, Brest Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 20, 2022 Category: Research Source Type: clinical trials

Rationale and design of the multicentric, double-blind, double-placebo, randomized trial APrepitant versus HYdroxyzine in association with cytoreductive treatments for patients with myeloproliferative neoplasia suffering from Persistent Aquagenic Pruritus. Trial acronym: APHYPAP
The objectives of APHYPAP are twofold: a clinical aim with the evaluation of the efficacy of two drugs in the treatment of a persistent AP for MPN patients and a biological aim to find clues to elucidate AP pathophysiology.Methods/designA multicentric, double-blind, double-placebo, randomized study will include 80 patients with MPN (PV or ET or PMF) treated since at least 6 months for their hemopathy but suffering from a persistent AP (VAS intensity ≥6/10). Patients will be randomized between aprepitant (80 mg daily) + placebo to match to hydroxyzine OR hydroxyzine (25 mg daily) + placebo to match to aprepitant fo...
Source: Trials - December 19, 2021 Category: Research Source Type: clinical trials

Maintenance Fedratinib to Prevent Post-Transplant Relapse in Myeloproliferative Neoplasms
Condition: Myeloproliferative Neoplasm Intervention: Drug: Fedratinib Pill Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Bristol-Myers Squibb Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 19, 2021 Category: Research Source Type: clinical trials