Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Two Way Relationship Between Cellular Senescence and Cancer in Bone Marrow
Cells become senescent in response to a variety of circumstances. The vast majority are cases of replicative senescence, somatic cells reaching the Hayflick limit. Cell damage and toxic environments also produce senescence, and senescent cells are also created as a part of the wound healing process. A senescent cell ceases replication and begins to secrete inflammatory and pro-growth signals, altering the nearby extracellular matrix and behavior of surrounding cells - even encouraging them to become senescent as well.
Near all senescent cells last a short time only, as they self-destruct or are removed by the immune...
Source: Fight Aging! - March 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Growing Importance of Medical Intervention
For most of the years while I was coming up in the world of public health and social policy, it was accepted truth that medical intervention made only a small contribution to population health. Quantifying " population health " as a single entity is obviously highly problematic. There are many components that people will value differently. There is mean life expectancy at birth, which is a common measure that is not terribly difficult to calculate; although as I have explained here before and won ' t bother to do again right now it ' s a fictitious construct that does not predict how long you actually have to live. Rather ...
Source: Stayin' Alive - January 9, 2020 Category: American Health Source Type: blogs
Obesity an important cause of high output heart failure
Obesity an important cause of high output heart failure: Conventionally we have been taught that causes of high out put failure are anemia, thyrotoxicosis, beriberi and arteriovenous fistula. But modern day data is changing. A retrospective analysis of patients with high output heart failure from the cathlab of Mayo Clinic [1] showed that obesity was the commonest cause contributing to almost one third of cases. This was followed by liver disease and arteriovenous shunts contributing about one fourth of cases each, lung disease and (16%) and myeloproliferative disorders (8%). Of course some bias in these percentages is p...
Source: Cardiophile MD - April 11, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology Source Type: blogs
Pulmonary hypertension in myeloproliferative disorders
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - February 20, 2017 Category: Internal Medicine Tags: cardiovascular hematology pulmonary Source Type: blogs
Test your medicine knowledge: 48-year-old woman with fatigue
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 48-year-old woman is evaluated for fatigue and intermittent abdominal discomfort of 2 months’ duration and occasional dark urine. Medical and family histories are unremarkable. Her only medication is an oral contraceptive pill.
On physical examination, temperature is 37.2 °C (99.0 °F), blood pressure is 125/74 mm Hg, pulse rate is 68/min, and respiration rate is 13/min. Pallor is observed, and abdominal tenderness is present on palpation. No icterus, bruising, or splenomegaly is noted.
Laboratory studi...
Source: Kevin, M.D. - Medical Weblog - October 17, 2015 Category: Journals (General) Authors: mksap Tags: Conditions Hematology Source Type: blogs
Rare Diseases Hiding Among Common Diseases
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. Here is an excerpt from Chapter 12:It is easy to find cases wherein a rare disease accounts for a somewhat uncommon clinical presentation of a common disease. 12.1.2 Rule—Uncommon presentations of common diseases are sometimes rare diseases, camouflaged by a common clinical phenotype. Brief Rationale—Common diseases tend to occur with a char...
Source: Specified Life - July 18, 2014 Category: Pathologists Tags: common disease cryptic disease disease genetics genetics of common diseases genetics of complex disease orphan disease orphan drugs rare disease subsets of disease Source Type: blogs
