Study protocol for a phase 1/2, single-centre, double-blind, double-dummy, randomized, active-controlled, age de-escalation trial to assess the safety, tolerability and immunogenicity of a measles and rubella vaccine delivered by a microneedle patch in healthy adults (18 to 40 years), measles and rubella vaccine-primed toddlers (15 to 18 months) and measles and rubella vaccine-na ïve infants (9 to 10 months) in The Gambia [Measles and Rubella Vaccine Microneedle Patch Phase 1/2 Age De-escalation Trial]
DiscussionThis trial will provide the first clinical data on the use of a MNP to deliver the MRV and the first data on the use of MNPs in a paediatric population. It will guide future product development decisions for what may be a key technology for future measles and rubella elimination.Trial registrationPan-African Clinical Trials Registry202008836432905.ClinicalTrials.govNCT04394689 (Source: Trials)
Source: Trials - September 14, 2022 Category: Research Source Type: clinical trials
Health effects of utilising hospital contacts to provide measles vaccination to children 9 –59 months—a randomised controlled trial in Guinea-Bissau
DiscussionUtilising missed vaccination opportunities can increase vaccination coverage and may improve child health. However, without further evidence for the safety and potential benefits of measles vaccination, these curative contacts are unlikely to be used for vaccination in Guinea-Bissau.Trial registrationwww.ClinicalTrials.govNCT04220671. Registered on 5 January 2020. (Source: Trials)
Source: Trials - April 23, 2022 Category: Research Source Type: clinical trials
The Immunogenicity and Safety of the Vaccination of Human Papillomavirus Vaccine and Measles-Mumps-Rubella Vaccine
Conditions: Human Papilloma Virus Infection Type 16; Human Papilloma Virus Infection Type 18; Measles; Rubella; Mumps Interventions: Biological: HPV+MMR（0d），HPV（6m）; Biological: HPV（0d），HPV（6m），MMR（7m）; Biological: MMR（0d），HPV（1m），HPV（7m） Sponsor: Zhejiang Provincial Center for Disease Control and Prevention Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2022 Category: Research Source Type: clinical trials
