Attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
DiscussionStrengths of the design include the use of multiple study sites with different transmission patterns and a range of vectors to improve external validity, a large number of clusters within each trial site, restricted randomization, between-cluster separation to minimize contamination between study arms, and an adaptive trial design. Noted threats to internal validity include open-label design, risk of contamination between study arms, risk of imbalance of covariates across study arms, variation in durability of ATSB stations, and potential disruption resulting from the COVID-19 pandemic.Trial registrationZambia: C...
Source: Trials - August 9, 2022 Category: Research Source Type: clinical trials
Epidemiology and Clinical Characteristics of Emerging and Re-emerging Infectious Diseases With Epidemic Potential in Mali
Condition: Febrile Illness Intervention: Other: Observational Study Sponsors: University Clinical Research Center, Mali; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 1, 2022 Category: Research Source Type: clinical trials
