Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial)
AbstractObjectivesTo assess the efficacy of several repurposed drugs to prevent hospitalisation or death in patients aged 65 or more with recent symptomatic SARS-CoV-2 infection (COVID-19) and no criteria for hospitalisation.Trial designPhase III, multi-arm (5) and multi-stage (MAMS), randomized, open-label controlled superiority trial.Participants will be randomly allocated 1:1:1:1:1 to the following strategies:Arm 1: Control armArms 2 to 5: Experimental treatment armsPlanned interim analyses will be conducted at regular intervals. Their results will be reviewed by an Independent Data and Safety Monitoring Board. Experime...
Source: Trials - October 13, 2020 Category: Research Source Type: clinical trials
Luxembourg Cohort of Positive Patients for COVID-19: a Stratification Study to Predict Patient Prognosis
Condition: Covid19 Intervention: Biological: Biological sampling Sponsors: Luxembourg Institute of Health; Centre Hospitalier du Luxembourg; Hopitaux Robert Schuman (Luxembourg); Laboratoire National de Santé (Luxembourg); University of Luxembourg Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 8, 2020 Category: Research Source Type: clinical trials
