Study Comparing the Pharmacokinetics, Safety, and Efficacy of RPH-075 and Keytruda ® in Patients With Malignant Neoplasms
Conditions: Skin Melanoma; Squamous Non-small-cell Lung Cancer; Head and Neck Squamous Cell Carcinoma Interventions: Drug: RPH-075; Drug: Keytruda ® Sponsors: R-Pharm; Data Management 365; Exacte Labs LLC; Federal State Budgetary Institution " NMIC of Hematology " of the Ministry of Health of the Russian Federation; Federal State Budgetary Institution of the Central Research Institute of Epidemiology of Rospotrebnadzor Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
MK-2870 Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) and Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
Conditions: Non-small Cell Lung Cancer (NSCLC) Interventions: Biological: MK-2870; Drug: Pemetrexed; Drug: Carboplatin; Drug: Antihistamine; Drug: H2 Receptor Antagonist; Drug: Acetaminophen (or equivalent); Drug: Dexamethasone (or equivalent) Sponsors: Merck Sharp& Dohme LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
A Phase Ib/II Clinical Study of GH21 Capsules Combined With Osimertinib Mesylate Tablets in Patients With NSCLC
Conditions: Non-Small Cell Lung Cancer With EGFR Mutation Interventions: Drug: GH21+Osimertinib Sponsors: Suzhou Genhouse Bio Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)
Conditions: Non Small Cell Lung Cancer Interventions: Device: Radiation Therapy; Drug: Targeted TKI therapy Sponsors: Medical College of Wisconsin Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
Precision Therapy for Solid Tumors: Synergistic CDK4/6 Inhibition and Anti-VEGF Targeting LncRNA
Conditions: Cancer; Solid Tumor; Colorectal Cancer; Breast Cancer; Ovarian Cancer; Lung Cancer; Targeted Therapy; Chemotherapy; Immunotherapy; Precision Therapy Interventions: Genetic: SNP; Drug: Palbociclib 125mg; Drug: Bevacizumab Sponsors: Lebanese University; Haykel Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
A Study of Adebrelimab Combined With Famitinib and Chemotherapy in the Treatment of ES-SCLC.
Conditions: Extensive-stage Small-cell Lung Cancer Interventions: Drug: adebrelimab; Drug: famitinib; Drug: chemotherapy Sponsors: Harbin Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
177Lu-anti-PD-L1 sdAb in Metastatic Non-small Cell Lung Cancer
Conditions: PDL1 Gene Mutation; Non Small Cell Lung Cancer Interventions: Drug: 177Lu-RAD204 Sponsors: Radiopharm Theranostics, Ltd Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
TGRX-326 Food Effect Pharmacokinetic Study
Conditions: Non Small Cell Lung Cancer Interventions: Drug: cycle 1: treatment drug; Drug: cycle 1: reference drug; Behavioral: cycle 1: fasted; Behavioral: cycle 1: food; Drug: cycle 2: treatment drug; Drug: cycle 2: reference drug; Behavioral: cycle 2: fasted; Behavioral: cycle 2: food; Drug: cycle 3: treatment drug; Drug: cycle 3: reference drug; Behavioral: cycle 3: fasted; Behavioral: cycle 3: food Sponsors: Shenzhen TargetRx, Inc.; First Affiliated Hospital Bengbu Medical College Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
Conditions: Ovarian Cancer; Non-small Cell Lung Cancer Interventions: Drug: TUB-040 Sponsors: Tubulis GmbH Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials
Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g.'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer
Conditions: Leptomeningeal Metastasis Interventions: Drug: Osimertinib; Drug: Pemetrexed Sponsors: Guangzhou Medical University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials
D-1553 Tablet Versus Docetaxel Injection for KRAS G12C Mutation-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer After Prior Standard Therapy Failure
Conditions: Non Small Cell Lung Cancer Interventions: Drug: D-1553 Tablet; Drug: Docetaxel injection Sponsors: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 8, 2024 Category: Research Source Type: clinical trials
Neoadjuvant Almonertinib Followed by Chemo-immunotherapy in II-IIIB EGFR-mutant NSCLC
Conditions: Non Small Cell Lung Cancer; EGFR Gene Mutation Interventions: Drug: almonertinib; Drug: Carboplatin; Drug: Nab paclitaxel Sponsors: Guangdong Provincial People ' s Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 8, 2024 Category: Research Source Type: clinical trials
Feasibility of Targeted Bronchial Washing Fluid for Molecular Testing With Next Generation Sequencing in Patients Suspicious of Early-stage Lung Cancer
Conditions: Lung Cancer Interventions: Diagnostic Test: Ultarthin bronchoscopy with intratumoral washing Sponsors: Pusan National University Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 8, 2024 Category: Research Source Type: clinical trials
Myeloprotection With Trilaciclib in Pan-cancer Population
Conditions: Non-Small Cell Lung Cancer; Breast Cancer; Endometrial Cancer; Cervical Cancer; Head And Neck Squamous Cell Carcinomas Interventions: Drug: Trilaciclib Injection; Drug: Paclitaxel; Drug: Carboplatin Sponsors: Sun Yat-sen University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials
Adebrelimab Plus Chemotherapy as Neoadjuvant Therapy in Resectable NSCLC Harboring Driver Gene Mutations
Conditions: Non Small Cell Lung Cancer Interventions: Drug: Adebrelimab; Drug: paclitaxel for injection (albumin bound); Drug: Cisplatin or Carboplatin Sponsors: Liaoning Tumor Hospital& Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials
