Linezolid Pilot Study
Condition: Syphilis Interventions: Drug: Group C, Linezolid 5; Drug: Group B, Linezolid 10d; Drug: Group A, Penicillin Sponsors: University of Southern California; Universidad Peruana Cayetano Heredia; The University of Texas Health Science Center, Houston Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 21, 2022 Category: Research Source Type: clinical trials
TB-PRACTECAL: study protocol for a randomised, controlled, open-label, phase II –III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis
DiscussionTB-PRACTECAL is an ambitious trial using adaptive design to accelerate regimen assessment and bring novel treatments that are effective and safe to patients quicker. The trial took a patient-centred approach, adapting to best practice guidelines throughout recruitment. The implementation faced significant challenges from the COVID-19 pandemic. The trial was terminated early for efficacy on the advice of the DSMB and will report on data collected up to the end of recruitment and, additionally, the planned final analysis at 72 weeks after the end of recruitment.Trial registrationClinicaltrials.gov NCT02589782. Re...
Source: Trials - June 13, 2022 Category: Research Source Type: clinical trials
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
Condition: Tuberculous Meningitis Interventions: Drug: Rifampicin (RIF); Drug: Isoniazid (INH); Drug: Linezolid (LZD); Drug: Pyrazinamide (PZA); Drug: ethambutol (EMB); Drug: Rifampicin; Drug: Isoniazid Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 20, 2022 Category: Research Source Type: clinical trials
