Chemoprophylaxis of leprosy with rifampicin in contacts of multibacillary patients: study protocol for a randomized controlled trial
DiscussionThe aim is to evaluate whether the use of chemoprophylaxis with a single dose of rifampicin in MB leprosy patient contacts prior to the BCG vaccine would be able to prevent the onset of leprosy in those cases that may occur just a few months after vaccination. Contact subclinical infections (polymerase chain reaction) and the immunological parameters (anti-PGL-1, anti-LID-1, and IFN- γ) will be evaluated and the results will be compared after 12 months of follow-up.Trial registrationThe Brazilian Registry of Clinical Trials (ReBEC),RBR-69QK5P. Retrospectively registered on 1 June 2017. (Source: Trials)
Source: Trials - April 23, 2018 Category: Research Source Type: clinical trials
A Study to Evaluate the Efficacy and Safety of Bedaquiline (TMC207) in Participants With Multibacillary Leprosy
Condition: Leprosy, Multibacillary Intervention: Drug: Bedaquiline 200 mg Sponsor: Janssen Research & Development, LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 27, 2017 Category: Research Source Type: clinical trials
