Wiley Interdisciplinary Reviews: Developmental Biology Wiley Interdisciplinary Reviews: Developmental Biology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Developmental regulation of planar cell polarity and hair‐bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics
Hearing loss is the most common and costly sensory defect in humans and genetic causes underlie a significant proportion of affected individuals. In mammals, sound is detected by hair cells (HCs) housed in the cochlea of the inner ear, whose function depends on a highly specialized mechanotransduction organelle, the hair bundle. Understanding the factors that regulate the development and functional maturation of the hair bundle is crucial for understanding the pathophysiology of human deafness. Genetic analysis of deafness genes in animal models, together with complementary forward genetic screens and conditional knock‐o...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - August 12, 2015 Category: Biology Authors: Xiaowei Lu, Conor W. Sipe Tags: Advanced Review Source Type: research

Tendon development and diseases
Abstract Tendon is a uniaxial connective tissue component of the musculoskeletal system. Tendon is involved in force transmission between muscle and bone. Tendon injury is very common and debilitating but tendon repair remains a clinical challenge for orthopedic medicine. In vertebrates, tendon is mainly composed of type I collagen fibrils, displaying a parallel organization along the tendon axis. The tendon‐specific spatial organization of type I collagen provides the mechanical properties for tendon function. In contrast to other components of the musculoskeletal system, tendon biology is poorly understood. An importan...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - August 7, 2015 Category: Biology Authors: Ludovic Gaut, Delphine Duprez Tags: Overview Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Developmental Biology)
Source: Wiley Interdisciplinary Reviews: Developmental Biology - August 6, 2015 Category: Biology Tags: Issue Information Source Type: research

The early life of a fly glial cell
Abstract Throughout evolution, glia have key regulatory roles in neural development and function. Typically, they control the response to developmental and/or pathological signals, thereby affecting neural proliferation, remodeling, survival, and regeneration. Such complex biology depends on the plastic features of glial cells, but also on the presence of different classes of glial cells, hence the importance of understanding the cellular and the molecular mechanisms underlying their development. The fly community has made major breakthroughs by characterizing the bases of gliogenesis and here we describe the glial lineage...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - July 1, 2015 Category: Biology Authors: Benjamin Altenhein, Pierre B. Cattenoz, Angela Giangrande Tags: Advanced Review Source Type: research

Differentiation of Drosophila glial cells
Glial cells are important constituents of the nervous system and a hallmark of these cells are their pronounced migratory abilities. In Drosophila, glial lineages have been well described and some of the molecular mechanisms necessary to guide migrating glial cells to their final target sites have been identified. With the onset of migration, glial cells are already specified into one of five main glial cell types. The perineurial and subperineurial glial cells are eventually located at the outer surface of the Drosophila nervous system and constitute the blood–brain barrier. The cortex glial cells ensheath all neuroblas...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - July 1, 2015 Category: Biology Authors: Sofia Sasse, Helen Neuert, Christian Klämbt Tags: Advanced Review Source Type: research

Unmasking the ciliopathies: craniofacial defects and the primary cilium
Over the past decade, the primary cilium has emerged as a pivotal sensory organelle that acts as a major signaling hub for a number of developmental signaling pathways. In that time, a vast number of proteins involved in trafficking and signaling have been linked to ciliary assembly and/or function, demonstrating the importance of this organelle during embryonic development. Given the central role of the primary cilium in regulating developmental signaling, it is not surprising that its dysfunction results in widespread defects in the embryo, leading to an expanding class of human congenital disorders known as ciliopathies...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - July 1, 2015 Category: Biology Authors: Claudio R. Cortés, Vicki Metzis, Carol Wicking Tags: Advanced Review Source Type: research

The wing and the eye: a parsimonious theory for scaling and growth control?
How a developing organ grows and patterns to its final shape is an important question in developmental biology. Studies of growth and patterning in the Drosophila wing imaginal disc have identified a key player, the morphogen Decapentaplegic (Dpp). These studies provided insights into our understanding of growth control and scaling: expansion of the Dpp gradient correlated with the growth of the tissue. A recent report on growth of a Drosophila organ other than the wing, the eye imaginal disc, prompts a reconsideration of our models of growth control. Despite striking differences between the two, the Dpp gradient scales wi...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - June 26, 2015 Category: Biology Authors: Maria Romanova‐Michaelides, Daniel Aguilar‐Hidalgo, Frank Jülicher, Marcos Gonzalez‐Gaitan Tags: Advanced Review Source Type: research

The complex of ASYMMETRIC LEAVES (AS) proteins plays a central role in antagonistic interactions of genes for leaf polarity specification in Arabidopsis
Leaf primordia are born around meristem‐containing stem cells at shoot apices, grow along three axes (proximal–distal, adaxial–abaxial, medial–lateral), and develop into flat symmetric leaves with adaxial–abaxial polarity. Axis development and polarity specification of Arabidopsis leaves require a network of genes for transcription factor‐like proteins and small RNAs. Here, we summarize present understandings of adaxial‐specific genes, ASYMMETRIC LEAVES1 (AS1) and AS2. Their complex (AS1–AS2) functions in the regulation of the proximal–distal leaf length by directly repressing class 1 KNOX homeobox genes ...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - June 24, 2015 Category: Biology Authors: Chiyoko Machida, Ayami Nakagawa, Shoko Kojima, Hiro Takahashi, Yasunori Machida Tags: Focus Article Source Type: research

Mechanisms of olfactory receptor neuron specification in Drosophila
Detection of a broad range of chemosensory signals is necessary for the survival of multicellular organisms. Chemical signals are the main facilitators of foraging, escape, and social behaviors. To increase detection coverage, animal sensory systems have evolved to create a large number of neurons with highly specific functions. The olfactory system, much like the nervous system as a whole, is astonishingly diverse.1‐3 The mouse olfactory system has millions of neurons with over a thousand classes, whereas the more compact Drosophila genome has approximately 80 odorant receptor genes that give rise to 50 neuronal classes...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - June 19, 2015 Category: Biology Authors: Scott Barish, Pelin Cayirlioglu Volkan Tags: Advanced Review Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Developmental Biology)
Source: Wiley Interdisciplinary Reviews: Developmental Biology - June 3, 2015 Category: Biology Tags: Issue Information Source Type: research

Salivary gland development and disease
Abstract Mammalian salivary glands synthesize and secrete saliva via a vast interconnected network of epithelial tubes attached to secretory end units. The extensive morphogenesis required to establish this organ is dependent on interactions between multiple cell types (epithelial, mesenchymal, endothelial, and neuronal) and the engagement of a wide range of signaling pathways. Here we describe critical regulators of salivary gland development and discuss how mutations in these impact human organogenesis. In particular, we explore the genetic contribution of growth factor pathways, nerve‐derived factors and extracellular...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - May 1, 2015 Category: Biology Authors: Aaron Mattingly, Jennifer K. Finley, Sarah M. Knox Tags: Advanced Review Source Type: research