Wiley Interdisciplinary Reviews: Developmental Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Methods for studying the metabolic basis of Drosophila development
The field of metabolic research has experienced an unexpected renaissance. While this renewed interest in metabolism largely originated in response to the global increase in diabetes and obesity, studies of metabolic regulation now represent the frontier of many biomedical fields. This trend is especially apparent in developmental biology, where metabolism influences processes ranging from stem cell differentiation and tissue growth to sexual maturation and reproduction. In this regard, the fruit fly Drosophila melanogaster has emerged as a powerful tool for dissecting conserved mechanisms that underlie developmental metab...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - May 1, 2017 Category: Biology Authors: Hongde Li, Jason M. Tennessen Tags: Focus Article Source Type: research

Phenotypic plasticity and remodeling in the stress ‐induced Caenorhabditis elegans dauer
Organisms are often capable of modifying their development to better suit their environment. Under adverse conditions, the nematode Caenorhabditis elegans develops into a stress‐resistant alternative larval stage called dauer. The dauer stage is the primary survival stage for C. elegans in nature. Large‐scale tissue remodeling during dauer conveys resistance to harsh environments. The environmental and genetic regulation of the decision to enter dauer has been extensively studied. However, less is known about the mechanisms regulating tissue remodeling. Changes to the cuticle and suppression of feeding in dauers lead t...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - May 1, 2017 Category: Biology Authors: Rebecca J. Androwski, Kristen M. Flatt, Nathan E. Schroeder Tags: Focus Article Source Type: research

Mouth development
A mouth is present in all animals, and comprises an opening from the outside into the oral cavity and the beginnings of the digestive tract to allow eating. This review focuses on the earliest steps in mouth formation. In the first half, we conclude that the mouth arose once during evolution. In all animals, the mouth forms from ectoderm and endoderm. A direct association of oral ectoderm and digestive endoderm is present even in triploblastic animals, and in chordates, this region is known as the extreme anterior domain (EAD). Further support for a single origin of the mouth is a conserved set of genes that form a ‘mout...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - May 1, 2017 Category: Biology Authors: Justin Chen, Laura A. Jacox, Francesca Saldanha, Hazel Sive Tags: Advanced Review Source Type: research

Quantification of epithelial cell proliferation, cell dynamics, and cell kinetics in vivo
The measurement of cell proliferation in vivo is usually carried out by the examination of static measures. These comprise the mitotic index or labeling indices using incorporation of DNA synthesis markers such as bromodeoxyuridine or tritiated thymidine, or intrinsic markers, such as Ki67 and proliferative cell nuclear antigen (PCNA). But static measures only provide a ‘snapshot’ of cell proliferation. Rate measures, including double labeling methods and the metaphase arrest method, can actually measure cell production rates but they are far less utilized at present. Transit times and migration rates can also be measu...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - May 1, 2017 Category: Biology Authors: Robert A. Goodlad Tags: Primer Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Developmental Biology)
Source: Wiley Interdisciplinary Reviews: Developmental Biology - April 21, 2017 Category: Biology Tags: Issue Information Source Type: research

Cover Image, Volume 6, Issue 3
The cover image, by Maria Jussila and Brian Ciruna, is based on the Focus Article Zebrafish models of non‐canonical Wnt/planar cell polarity signalling: fishing for valuable insight into vertebrate polarized cell behavior, DOI: 10.1002/wdev.267. The cover image, by Maria Jussila and Brian Ciruna, is based on the Focus Article Zebrafish models of non‐canonical Wnt/planar cell polarity signalling: fishing for valuable insight into vertebrate polarized cell behavior, DOI: 10.1002/wdev.267. (Source: Wiley Interdisciplinary Reviews: Developmental Biology)
Source: Wiley Interdisciplinary Reviews: Developmental Biology - April 21, 2017 Category: Biology Authors: Maria Jussila, Brian Ciruna Tags: Cover Image Source Type: research

Potential mechanisms of Zika ‐linked microcephaly
A recent outbreak of Zika virus (ZIKV) in Brazil is associated with microcephaly in infants born of infected mothers. As this pandemic spreads, rapid scientific investigation is shedding new light on how prenatal infection with ZIKV causes microcephaly. In this analysis we provide an overview of both microcephaly and ZIKV, explore the connection between prenatal ZIKV infection and microcephaly, and highlight recent insights into how prenatal ZIKV infection depletes the pool of neural progenitors in the developing brain. For further resources related to this article, please visit the WIREs website. Zika virions likely bind...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - April 6, 2017 Category: Biology Authors: Emily Merfeld, Lily Ben ‐Avi, Mason Kennon, Kara L. Cerveny Tags: Primer Source Type: research

Morphogen interpretation: concentration, time, competence, and signaling dynamics
Tissue patterning during animal development is orchestrated by a handful of inductive signals. Most of these developmental cues act as morphogens, meaning they are locally produced secreted molecules that act at a distance to govern tissue patterning. The iterative use of the same signaling molecules in different developmental contexts demands that signal interpretation occurs in a highly context‐dependent manner. Hence the interpretation of signal depends on the specific competence of the receiving cells. Moreover, it has become clear that the differential interpretation of morphogens depends not only on the level of si...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - March 19, 2017 Category: Biology Authors: Andreas Sagner, James Briscoe Tags: Advanced Review Source Type: research

Proximity ‐dependent labeling methods for proteomic profiling in living cells
Characterizing the proteome composition of organelles and subcellular regions of living cells can facilitate the understanding of cellular organization as well as protein interactome networks. Proximity labeling‐based methods coupled with mass spectrometry (MS) offer a high‐throughput approach for systematic analysis of spatially restricted proteomes. Proximity labeling utilizes enzymes that generate reactive radicals to covalently tag neighboring proteins with biotin. The biotinylated endogenous proteins can then be isolated for further analysis by MS. To analyze protein–protein interactions or identify components t...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - March 1, 2017 Category: Biology Authors: Chiao ‐Lin Chen, Norbert Perrimon Tags: Focus Article Source Type: research

Nervous system development and regeneration in freshwater planarians
Planarians have a long history in the fields of developmental and regenerative biology. These animals have also sparked interest in neuroscience due to their neuroanatomy, spectrum of simple behaviors, and especially, their almost unparalleled ability to generate new neurons after any type of injury. Research in adult planarians has revealed that neuronal subtypes homologous to those found in vertebrates are generated from stem cells throughout their lives. This feat is recapitulated after head amputation, wherein animals are capable of regenerating whole brains and regaining complete neural function. In this review, we su...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - March 1, 2017 Category: Biology Authors: Kelly G. Ross, Ko W. Currie, Bret J. Pearson, Ricardo M. Zayas Tags: Advanced Review Source Type: research

The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies
In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. For further resources related to this article, please visit the WIREs website. Two early limb bud regulatory domains generate two halves of the limb skeleton. (Source: Wiley Interdisciplinary Reviews: Developmental Biology)
Source: Wiley Interdisciplinary Reviews: Developmental Biology - February 28, 2017 Category: Biology Authors: Hirotaka Tao, Yasuhiko Kawakami, Chi ‐chung Hui, Sevan Hopyan Tags: Advanced Review Source Type: research

Zebrafish models of non ‐canonical Wnt/planar cell polarity signalling: fishing for valuable insight into vertebrate polarized cell behavior
Planar cell polarity (PCP) coordinates the uniform orientation, structure and movement of cells within the plane of a tissue or organ system. It is beautifully illustrated in the polarized arrangement of bristles and hairs that project from specialized cell surfaces of the insect abdomen and wings, and pioneering genetic studies using the fruit fly, Drosophila melanogaster, have defined a core signalling network underlying PCP. This core PCP/non‐canonical Wnt signalling pathway is evolutionarily conserved, and studies in zebrafish have helped transform our understanding of PCP from a peculiarity of polarized epithelia to...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - February 28, 2017 Category: Biology Authors: Maria Jussila, Brian Ciruna Tags: Focus Article Source Type: research

Topologically associated domains: a successful scaffold for the evolution of gene regulation in animals
The evolution of gene regulation is considered one of the main drivers causing the astonishing morphological diversity in the animal kingdom. Gene regulation in animals heavily depends upon cis‐regulatory elements, discrete pieces of DNA that interact with target promoters to regulate gene expression. In the last years, Chromosome Conformation Capture experiments (4C‐seq, 5C, and HiC) in several organisms have shown that the genomes of many bilaterian animals are organized in the 3D chromatin space in compartments called topologically associated domains (TADs). The appearance of the architectural protein CTCF in the bi...
Source: Wiley Interdisciplinary Reviews: Developmental Biology - February 28, 2017 Category: Biology Authors: Rafael D. Acemel, Ignacio Maeso, Jos é Luis Gómez‐Skarmeta Tags: Advanced Review Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Developmental Biology)
Source: Wiley Interdisciplinary Reviews: Developmental Biology - February 16, 2017 Category: Biology Tags: Issue Information Source Type: research

Inside Cover Image, Volume 6, Issue 2
The inside cover image, by Matthew J. Stower and Federica Bertocchini, is based on the Advanced Review The Evolution of amniote gastrulation: the blastopore‐primitive streak transition, DOI: 10.1002/wdev.262. The inside cover image, by Matthew J. Stower and Federica Bertocchini, is based on the Advanced Review The Evolution of amniote gastrulation: the blastopore‐primitive streak transition, DOI: 10.1002/wdev.262. (Source: Wiley Interdisciplinary Reviews: Developmental Biology)
Source: Wiley Interdisciplinary Reviews: Developmental Biology - February 16, 2017 Category: Biology Authors: Matthew J. Stower, Federica Bertocchini Tags: Cover Image Source Type: research