Partly unequal receipt of healthcare in last month of life in amyotrophic lateral sclerosis: a retrospective cohort study of the Stockholm region
CONCLUSIONS: The results indicate partly unequal distribution of palliative care, however the actual, individual preferences cannot be deducted from registry studies. All patients with ALS should be offered SPC when needed.KEY MESSAGE: This register study shows that receipt of SPC in patients with ALS is equal in relation to gender, socioeconomic standing, frailty, and age <75 years, while those ≥75 years, with dementia, or residing in NH were somewhat less likely to receive SPC. Receipt of SPC reduces ER visits and acute hospital admissions.PMID:38371486 | PMC:PMC10870957 | DOI:10.48101/ujms.v129.9856 (Source: Upsala...
Source: Upsala Journal of Medical Sciences - February 19, 2024 Category: General Medicine Authors: Peter Strang Torbj örn Schultz Anneli Ozanne Source Type: research
Partly unequal receipt of healthcare in last month of life in amyotrophic lateral sclerosis: a retrospective cohort study of the Stockholm region
CONCLUSIONS: The results indicate partly unequal distribution of palliative care, however the actual, individual preferences cannot be deducted from registry studies. All patients with ALS should be offered SPC when needed.KEY MESSAGE: This register study shows that receipt of SPC in patients with ALS is equal in relation to gender, socioeconomic standing, frailty, and age <75 years, while those ≥75 years, with dementia, or residing in NH were somewhat less likely to receive SPC. Receipt of SPC reduces ER visits and acute hospital admissions.PMID:38371486 | PMC:PMC10870957 | DOI:10.48101/ujms.v129.9856 (Source: Upsala...
Source: Upsala Journal of Medical Sciences - February 19, 2024 Category: General Medicine Authors: Peter Strang Torbj örn Schultz Anneli Ozanne Source Type: research
Partly unequal receipt of healthcare in last month of life in amyotrophic lateral sclerosis: a retrospective cohort study of the Stockholm region
CONCLUSIONS: The results indicate partly unequal distribution of palliative care, however the actual, individual preferences cannot be deducted from registry studies. All patients with ALS should be offered SPC when needed.KEY MESSAGE: This register study shows that receipt of SPC in patients with ALS is equal in relation to gender, socioeconomic standing, frailty, and age <75 years, while those ≥75 years, with dementia, or residing in NH were somewhat less likely to receive SPC. Receipt of SPC reduces ER visits and acute hospital admissions.PMID:38371486 | PMC:PMC10870957 | DOI:10.48101/ujms.v129.9856 (Source: Upsala...
Source: Upsala Journal of Medical Sciences - February 19, 2024 Category: General Medicine Authors: Peter Strang Torbj örn Schultz Anneli Ozanne Source Type: research
A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels
CONCLUSIONS: The evolocumab LDL-C-lowering effect observed in clinical trials was confirmed in clinical practice in Sweden, particularly in patients also treated with oral LLT. During follow-up, adherence to and persistence with evolocumab were high, with stable reduced levels of LDL-C during observation.PMID:38327639 | PMC:PMC10845886 | DOI:10.48101/ujms.v129.9618 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Maria K Svensson Stefan James Annica Ravn-Fischer Guillermo Villa Lovisa Schalin Thomas Cars Stefan Gustafsson Emil Hagstr öm Source Type: research
COVID-19: Not a thrombotic disease but a thromboinflammatory disease
This study aims to reaffirm our previous hypothesis that COVID-19 is fundamentally a thrombotic disease. To accomplish this, we have undertaken an extensive literature review focused on assessing the comprehensive impact of COVID-19 on the entire hemostatic system. Our analysis revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly enhances the initiation of thrombin generation. However, it is noteworthy that the thrombin generation may be modulated by specific anticoagulants present in patients' plasma. Consequently, higher levels of fibrinogen appear to play a more pivotal role...
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Shu He Margareta Blomb äck H åkan Wallén Source Type: research
A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels
CONCLUSIONS: The evolocumab LDL-C-lowering effect observed in clinical trials was confirmed in clinical practice in Sweden, particularly in patients also treated with oral LLT. During follow-up, adherence to and persistence with evolocumab were high, with stable reduced levels of LDL-C during observation.PMID:38327639 | PMC:PMC10845886 | DOI:10.48101/ujms.v129.9618 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Maria K Svensson Stefan James Annica Ravn-Fischer Guillermo Villa Lovisa Schalin Thomas Cars Stefan Gustafsson Emil Hagstr öm Source Type: research
COVID-19: Not a thrombotic disease but a thromboinflammatory disease
This study aims to reaffirm our previous hypothesis that COVID-19 is fundamentally a thrombotic disease. To accomplish this, we have undertaken an extensive literature review focused on assessing the comprehensive impact of COVID-19 on the entire hemostatic system. Our analysis revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly enhances the initiation of thrombin generation. However, it is noteworthy that the thrombin generation may be modulated by specific anticoagulants present in patients' plasma. Consequently, higher levels of fibrinogen appear to play a more pivotal role...
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Shu He Margareta Blomb äck H åkan Wallén Source Type: research
A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels
CONCLUSIONS: The evolocumab LDL-C-lowering effect observed in clinical trials was confirmed in clinical practice in Sweden, particularly in patients also treated with oral LLT. During follow-up, adherence to and persistence with evolocumab were high, with stable reduced levels of LDL-C during observation.PMID:38327639 | PMC:PMC10845886 | DOI:10.48101/ujms.v129.9618 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Maria K Svensson Stefan James Annica Ravn-Fischer Guillermo Villa Lovisa Schalin Thomas Cars Stefan Gustafsson Emil Hagstr öm Source Type: research
COVID-19: Not a thrombotic disease but a thromboinflammatory disease
This study aims to reaffirm our previous hypothesis that COVID-19 is fundamentally a thrombotic disease. To accomplish this, we have undertaken an extensive literature review focused on assessing the comprehensive impact of COVID-19 on the entire hemostatic system. Our analysis revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly enhances the initiation of thrombin generation. However, it is noteworthy that the thrombin generation may be modulated by specific anticoagulants present in patients' plasma. Consequently, higher levels of fibrinogen appear to play a more pivotal role...
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Shu He Margareta Blomb äck H åkan Wallén Source Type: research
A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels
CONCLUSIONS: The evolocumab LDL-C-lowering effect observed in clinical trials was confirmed in clinical practice in Sweden, particularly in patients also treated with oral LLT. During follow-up, adherence to and persistence with evolocumab were high, with stable reduced levels of LDL-C during observation.PMID:38327639 | PMC:PMC10845886 | DOI:10.48101/ujms.v129.9618 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Maria K Svensson Stefan James Annica Ravn-Fischer Guillermo Villa Lovisa Schalin Thomas Cars Stefan Gustafsson Emil Hagstr öm Source Type: research
COVID-19: Not a thrombotic disease but a thromboinflammatory disease
This study aims to reaffirm our previous hypothesis that COVID-19 is fundamentally a thrombotic disease. To accomplish this, we have undertaken an extensive literature review focused on assessing the comprehensive impact of COVID-19 on the entire hemostatic system. Our analysis revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly enhances the initiation of thrombin generation. However, it is noteworthy that the thrombin generation may be modulated by specific anticoagulants present in patients' plasma. Consequently, higher levels of fibrinogen appear to play a more pivotal role...
Source: Upsala Journal of Medical Sciences - February 8, 2024 Category: General Medicine Authors: Shu He Margareta Blomb äck H åkan Wallén Source Type: research
High iNOS and IL-1 β immunoreactivity are features of colitis-associated colorectal cancer tumors, but fail to predict 5-year survival
CONCLUSION: Consistent with high NO production in IBD, there is more iNOS in CAC epithelium, albeit not in stroma. This immunoreactivity difference exists for IL-1β in both epithelium and stroma. The intervention of arginine or iNOS activity for CAC chemotherapy is not straightforward.PMID:38187473 | PMC:PMC10770641 | DOI:10.48101/ujms.v128.10241 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 8, 2024 Category: General Medicine Authors: Kajsa Bj örner Wei-Na Chen Venkata Ram Gannavarapu Fredrik Axling Miklos Gulyas Mohammad Abdul Halim Dominic-Luc Webb Per M Hellstr öm Source Type: research
Dose-dependent regulation of kidney mitochondrial function by angiotensin II
CONCLUSIONS: In conclusion, Ang II dose-dependently affects mitochondrial function and leak respiration. Thus, Ang II has the potential to directly affect cellular metabolism during conditions of altered Ang II signaling.PMID:38188249 | PMC:PMC10770640 | DOI:10.48101/ujms.v128.10312 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 8, 2024 Category: General Medicine Authors: Ebba Sivertsson Amanda Balboa Tomas A Schiffer Peter Hansell Malou Friederich-Persson Patrik Persson Fredrik Palm Source Type: research
A temporary regulation to manage an impending shortage due to extraordinary prescribing patterns of chloroquines observed during early phase of COVID-19 epidemic
CONCLUSION: After an observed increase in prescriptions of C/HC, a temporary regulation was introduced on 2nd April 2020 to reduce prescriptions from specialists not usually prescribing C/HC to avoid shortages for patients within approved indications. Subsequently, dispensed prescriptions decreased from April and remained at pre-COVID-19 levels thereafter.PMID:38188250 | PMC:PMC10770639 | DOI:10.48101/ujms.v128.10033 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 8, 2024 Category: General Medicine Authors: Karl-Mikael K älkner Anders Sundstr öm Maria Juhasz Haverinen Kenneth Nordback Veronica Arthurson Bj örn Zethelius Rickard Ljung Source Type: research
High iNOS and IL-1 β immunoreactivity are features of colitis-associated colorectal cancer tumors, but fail to predict 5-year survival
CONCLUSION: Consistent with high NO production in IBD, there is more iNOS in CAC epithelium, albeit not in stroma. This immunoreactivity difference exists for IL-1β in both epithelium and stroma. The intervention of arginine or iNOS activity for CAC chemotherapy is not straightforward.PMID:38187473 | PMC:PMC10770641 | DOI:10.48101/ujms.v128.10241 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 8, 2024 Category: General Medicine Authors: Kajsa Bj örner Wei-Na Chen Venkata Ram Gannavarapu Fredrik Axling Miklos Gulyas Mohammad Abdul Halim Dominic-Luc Webb Per M Hellstr öm Source Type: research
