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Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression
The objective of the present study was to evaluate the effect and underlying possible neuroprotective mechanism of rTMS and fluoxetine on abnormal behaviors in a depressive mouse model induced by chronic unpredictable mild stress (CUMS). After 28 days of CUMS exposure, mice were chronically treated with rTMS (10 Hz for 5 seconds per train, total 20 trains per day) and (or) fluoxetine (5 mg/kg/day, intraperitoneally) for 28 days targeting on the frontal cortex. After the behavioral tests, the protein expressions of glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) ...
Source: The World Journal of Biological Psychiatry - November 9, 2023 Category: Psychiatry Authors: Qianfa Yuan Yuying Lei Kai Yu Junnan Wu Zhizhong Xu Chunyan Wen Yanlong Liu Wenqiang Wang Jue He Source Type: research

Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression
The objective of the present study was to evaluate the effect and underlying possible neuroprotective mechanism of rTMS and fluoxetine on abnormal behaviors in a depressive mouse model induced by chronic unpredictable mild stress (CUMS). After 28 days of CUMS exposure, mice were chronically treated with rTMS (10 Hz for 5 seconds per train, total 20 trains per day) and (or) fluoxetine (5 mg/kg/day, intraperitoneally) for 28 days targeting on the frontal cortex. After the behavioral tests, the protein expressions of glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) ...
Source: The World Journal of Biological Psychiatry - November 9, 2023 Category: Psychiatry Authors: Qianfa Yuan Yuying Lei Kai Yu Junnan Wu Zhizhong Xu Chunyan Wen Yanlong Liu Wenqiang Wang Jue He Source Type: research

Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression
The objective of the present study was to evaluate the effect and underlying possible neuroprotective mechanism of rTMS and fluoxetine on abnormal behaviors in a depressive mouse model induced by chronic unpredictable mild stress (CUMS). After 28 days of CUMS exposure, mice were chronically treated with rTMS (10 Hz for 5 seconds per train, total 20 trains per day) and (or) fluoxetine (5 mg/kg/day, intraperitoneally) for 28 days targeting on the frontal cortex. After the behavioral tests, the protein expressions of glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) ...
Source: The World Journal of Biological Psychiatry - November 9, 2023 Category: Psychiatry Authors: Qianfa Yuan Yuying Lei Kai Yu Junnan Wu Zhizhong Xu Chunyan Wen Yanlong Liu Wenqiang Wang Jue He Source Type: research

The relationship between alterations in plasma metabolites and treatment responses in antipsychotic-na ïve female patients with schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research

The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Na ïve Female Patients with Schizophrenia
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to pred...
Source: The World Journal of Biological Psychiatry - October 22, 2023 Category: Psychiatry Authors: Xiaoli Wang Jun Xie Hongyun Ma Gang Li Meijuan Li Shen Li Xiaoxiao Sun Yongping Zhao Wei Sun Shu Yang Jie Li Source Type: research