Glycolytic enzymes as vaccines against schistosomiasis: testing schistosoma mansoni phosphoglycerate mutase in mice
J Parasitol. 2024 Mar 1;110(2):96-105. doi: 10.1645/23-7.ABSTRACTSchistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additio...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: David B Pirovich Akram A Da'dara Patrick J Skelly Source Type: research
Characterization of eimeria lancasterensis and eimeria ontarioensis (apicomplexa: eimeriidae) found in eastern gray squirrels, sciurus carolinensis (rodentia: sciuridae), from arkansas and oklahoma
We report the morphological characteristics of oocysts of Eimeria lancasterensisJoseph, 1969, collected from 6 of 6 (100%) eastern gray squirrels, Sciurus carolinensis, collected in Arkansas (n = 3) and Oklahoma (n = 3), and Eimeria ontarioensisLee and Dorney, 1971, recovered from an individual of S. carolinensis from Arkansas. Oocysts of E. lancasterensis were ovoidal to ellipsoidal, measuring (L × W) 24.0 × 14.6 (18-29 × 12-16) µm; shape index (L/W) was 1.6 (1.3-1.8). A micropyle and an oocyst residuum were absent, but up to 2 polar granules were present. Oocysts of E. ontarioensis were piriform and measured 40.6 × ...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: Chris T McAllister Dagmara Motriuk-Smith Hunter McCurdy R Scott Seville Source Type: research
Glycolytic enzymes as vaccines against schistosomiasis: testing schistosoma mansoni phosphoglycerate mutase in mice
J Parasitol. 2024 Mar 1;110(2):96-105. doi: 10.1645/23-7.ABSTRACTSchistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additio...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: David B Pirovich Akram A Da'dara Patrick J Skelly Source Type: research
Characterization of eimeria lancasterensis and eimeria ontarioensis (apicomplexa: eimeriidae) found in eastern gray squirrels, sciurus carolinensis (rodentia: sciuridae), from arkansas and oklahoma
We report the morphological characteristics of oocysts of Eimeria lancasterensisJoseph, 1969, collected from 6 of 6 (100%) eastern gray squirrels, Sciurus carolinensis, collected in Arkansas (n = 3) and Oklahoma (n = 3), and Eimeria ontarioensisLee and Dorney, 1971, recovered from an individual of S. carolinensis from Arkansas. Oocysts of E. lancasterensis were ovoidal to ellipsoidal, measuring (L × W) 24.0 × 14.6 (18-29 × 12-16) µm; shape index (L/W) was 1.6 (1.3-1.8). A micropyle and an oocyst residuum were absent, but up to 2 polar granules were present. Oocysts of E. ontarioensis were piriform and measured 40.6 × ...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: Chris T McAllister Dagmara Motriuk-Smith Hunter McCurdy R Scott Seville Source Type: research
Glycolytic enzymes as vaccines against schistosomiasis: testing schistosoma mansoni phosphoglycerate mutase in mice
J Parasitol. 2024 Mar 1;110(2):96-105. doi: 10.1645/23-7.ABSTRACTSchistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additio...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: David B Pirovich Akram A Da'dara Patrick J Skelly Source Type: research
Characterization of eimeria lancasterensis and eimeria ontarioensis (apicomplexa: eimeriidae) found in eastern gray squirrels, sciurus carolinensis (rodentia: sciuridae), from arkansas and oklahoma
We report the morphological characteristics of oocysts of Eimeria lancasterensisJoseph, 1969, collected from 6 of 6 (100%) eastern gray squirrels, Sciurus carolinensis, collected in Arkansas (n = 3) and Oklahoma (n = 3), and Eimeria ontarioensisLee and Dorney, 1971, recovered from an individual of S. carolinensis from Arkansas. Oocysts of E. lancasterensis were ovoidal to ellipsoidal, measuring (L × W) 24.0 × 14.6 (18-29 × 12-16) µm; shape index (L/W) was 1.6 (1.3-1.8). A micropyle and an oocyst residuum were absent, but up to 2 polar granules were present. Oocysts of E. ontarioensis were piriform and measured 40.6 × ...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: Chris T McAllister Dagmara Motriuk-Smith Hunter McCurdy R Scott Seville Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
Theileria equi infection in working horses of pakistan: epidemiology, molecular characterization, and hematobiochemical analysis
J Parasitol. 2024 Feb 1;110(1):79-89. doi: 10.1645/23-58.ABSTRACTTheileria equi is 1 of the emerging and prevailing tick-borne hemoprotozoans adversely affecting the equids worldwide, including Pakistan. The current study aimed to investigate the prevalence and molecular characterization of T. equi in working horses (n = 194), the comparative efficacy of different diagnostic tests, associated risk factors, and hematobiochemical analysis. The blood samples of horses were subjected to microscopic examination, cELISA, and polymerase chain reaction (PCR) and the results revealed a prevalence of 9.79, 21.13, and 13.40%, respect...
Source: The Journal of Parasitology - February 29, 2024 Category: Parasitology Authors: Ahmed Raza Muhammad Ijaz Khalid Mehmood Arslan Ahmed Muhammad Umar Javed Farwa Anwaar Hamza Rasheed Nauman Zaheer Ghumman Source Type: research
