Opioid-induced hypogonadism in opioid use disorder, its role in negative reinforcement, and implications for treatment and retention
Am J Drug Alcohol Abuse. 2024 Feb 6:1-7. doi: 10.1080/00952990.2023.2292012. Online ahead of print.ABSTRACTHypogonadism is a highly prevalent complication of chronic opioid use associated with a constellation of affective, algesic, and cognitive symptoms as well as decreased quality of life. Given that the mainstays of pharmacologic opioid use disorder (OUD) treatment - methadone and buprenorphine - are themselves agonists or partial agonists at the mu opioid receptor, opioid-induced hypogonadism (OIH) remains an underappreciated clinical concern throughout the course of OUD treatment. Prominent theoretical frameworks for ...
Source: The American Journal of Drug and Alcohol Abuse - February 6, 2024 Category: Addiction Authors: Avery F McGuirt Christina A Brezing Source Type: research

Opioid-induced hypogonadism in opioid use disorder, its role in negative reinforcement, and implications for treatment and retention
Am J Drug Alcohol Abuse. 2024 Feb 6:1-7. doi: 10.1080/00952990.2023.2292012. Online ahead of print.ABSTRACTHypogonadism is a highly prevalent complication of chronic opioid use associated with a constellation of affective, algesic, and cognitive symptoms as well as decreased quality of life. Given that the mainstays of pharmacologic opioid use disorder (OUD) treatment - methadone and buprenorphine - are themselves agonists or partial agonists at the mu opioid receptor, opioid-induced hypogonadism (OIH) remains an underappreciated clinical concern throughout the course of OUD treatment. Prominent theoretical frameworks for ...
Source: The American Journal of Drug and Alcohol Abuse - February 6, 2024 Category: Addiction Authors: Avery F McGuirt Christina A Brezing Source Type: research

Opioid-induced hypogonadism in opioid use disorder, its role in negative reinforcement, and implications for treatment and retention
Am J Drug Alcohol Abuse. 2024 Feb 6:1-7. doi: 10.1080/00952990.2023.2292012. Online ahead of print.ABSTRACTHypogonadism is a highly prevalent complication of chronic opioid use associated with a constellation of affective, algesic, and cognitive symptoms as well as decreased quality of life. Given that the mainstays of pharmacologic opioid use disorder (OUD) treatment - methadone and buprenorphine - are themselves agonists or partial agonists at the mu opioid receptor, opioid-induced hypogonadism (OIH) remains an underappreciated clinical concern throughout the course of OUD treatment. Prominent theoretical frameworks for ...
Source: The American Journal of Drug and Alcohol Abuse - February 6, 2024 Category: Addiction Authors: Avery F McGuirt Christina A Brezing Source Type: research

Opioid-induced hypogonadism in opioid use disorder, its role in negative reinforcement, and implications for treatment and retention
Am J Drug Alcohol Abuse. 2024 Feb 6:1-7. doi: 10.1080/00952990.2023.2292012. Online ahead of print.ABSTRACTHypogonadism is a highly prevalent complication of chronic opioid use associated with a constellation of affective, algesic, and cognitive symptoms as well as decreased quality of life. Given that the mainstays of pharmacologic opioid use disorder (OUD) treatment - methadone and buprenorphine - are themselves agonists or partial agonists at the mu opioid receptor, opioid-induced hypogonadism (OIH) remains an underappreciated clinical concern throughout the course of OUD treatment. Prominent theoretical frameworks for ...
Source: The American Journal of Drug and Alcohol Abuse - February 6, 2024 Category: Addiction Authors: Avery F McGuirt Christina A Brezing Source Type: research

Fiduciary assignment as a potential intervention for substance use disorder: a retrospective chart review
Conclusions: Understanding the clinical impact of fiduciary assignment for veteran's benefits is desirable but still pending at this time.PMID:38299775 | DOI:10.1080/00952990.2023.2286584 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - February 1, 2024 Category: Addiction Authors: Amanda von Horn David Hathaway Janet Richmond Grace Chang Source Type: research

A scoping review of health inequities in alcohol use disorder
Conclusions: This scoping review highlights the gaps in research on inequities in AUD. To bridge the current gaps, we recommend research on the following: 1) triage screening tools and the use of telemedicine for rural, under-resourced populations; 2) interventions to increase treatment engagement and retention for women; and 3) community-based participatory methodologies for the LGBTQ+ communities.PMID:38295346 | DOI:10.1080/00952990.2023.2296860 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 31, 2024 Category: Addiction Authors: Shaelyn Ward Josh Autaubo Philo Waters Elizabeth Garrett Kelsi Batioja Reece Anderson Debra Furr-Holden Matt Vassar Source Type: research

Racial and ethnic inequities in substance use treatment among women with opioid use disorder
Conclusions: Receipt of treatment is low among women with OUD, especially Black and Hispanic women. Intersectional intervention approaches are needed to increase access and reduce inequities.PMID:38295349 | DOI:10.1080/00952990.2023.2291748 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 31, 2024 Category: Addiction Authors: Joy D Scheidell Maya Pitre Barbara Andraka-Christou Source Type: research

GxE interaction effects of < em > HCRTR2 < /em > single nucleotide polymorphism and adverse childhood experiences on methamphetamine use disorder
Conclusion: HCRTR2 SNP rs2653349 has no significant impact on MUD risk, but ACEs may increase this risk. GxE results suggest that rs2653349 could offer protection against developing MUD in individuals experiencing multiple types of ACEs.PMID:38295363 | DOI:10.1080/00952990.2023.2297661 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 31, 2024 Category: Addiction Authors: Kai-Ting Chen Ming-Chyi Huang Chun Lin Hu-Ming Chang Chung-Feng Kao Source Type: research

Initial evidence of reliability and validity of an implicit association test assessing attitudes toward individuals who use substances
Conclusion: These results provide compelling preliminary evidence of validity of an IAT designed to measure bias toward individuals who use substances.PMID:38295383 | DOI:10.1080/00952990.2023.2300398 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 31, 2024 Category: Addiction Authors: Erik M Benau Jillian H Zavodnick Rebecca C Jaffe Source Type: research

Feasibility of a telehealth-based contingency management intervention for alcohol use disorders using the phosphatidylethanol (PEth) 16:0/18:1 alcohol biomarker: a pilot randomized trial
Conclusion: Results support the acceptability and satisfaction of a telehealth PEth-based CM intervention, though a larger study is needed to assess its efficacy [NCT04038021].PMID:38284925 | DOI:10.1080/00952990.2023.2283691 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 29, 2024 Category: Addiction Authors: Julianne D Jett Rachael Beck Diana Tyutyunnyk Jesus Sanchez Douglas L Weeks Martin A Javors Nathalie Hill-Kapturczak Marisa Lopez-Cruzan Liat Kriegel Brett C Ginsburg Leopoldo Cabassa Michael G McDonell Source Type: research

Cannabis use in adolescents and anxiety symptoms and disorders: a systematic review and meta-analysis
Discussion: In summary, the current evidence suggests a prospective association between adolescent cannabis use and later anxiety symptoms and disorders. These findings underscore the importance of refining research methodologies, considering sex-based differences and controlling for confounding factors, as well as implementing educational initiatives and developing clinical interventions to address the mental health risks associated with cannabis use among adolescents.PMID:38285048 | DOI:10.1080/00952990.2023.2299922 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 29, 2024 Category: Addiction Authors: Darby J E Lowe Maryam Sorkhou Tony P George Source Type: research

Opioid overdose after extended-release buprenorphine injection: a case report
Am J Drug Alcohol Abuse. 2024 Jan 22:1-2. doi: 10.1080/00952990.2023.2292011. Online ahead of print.NO ABSTRACTPMID:38252881 | DOI:10.1080/00952990.2023.2292011 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 22, 2024 Category: Addiction Authors: Raluca Isenberg Source Type: research

Effects of fisetin on ethanol-induced rewarding properties in mice
Conclusions: Fisetin appears to diminish the rewarding properties of ethanol, as indicated by its inhibitory effect and facilitation of extinction in ethanol-induced CPP. These findings imply a potential therapeutic application of fisetin in preventing ethanol-seeking behavior, promoting extinction, and reducing the risk of relapse.PMID:38235981 | DOI:10.1080/00952990.2023.2292976 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 18, 2024 Category: Addiction Authors: Yasin Yalniz Oru ç Yunusoğlu Mehmet Berk öz Mustafa Enes Demirel Source Type: research

Ethanol causes non-communicable disease through activation of NLRP3 inflammasome: a review on mechanism of action and potential interventions
Conclusion: Preclinical research supports a role for ethanol-induced NLRP3 inflammasome in the development of NCDs. However, the clinical relevance remains uncertain in the relative absence of clinical studies.PMID:38237017 | DOI:10.1080/00952990.2023.2297349 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 18, 2024 Category: Addiction Authors: Ruizi Liu Bin Zhao Jie Zhao Meng Zhang Source Type: research

The association of alcohol consumption with the risk of sarcopenia: a dose-response meta-analysis
Conclusions: The results of this meta-analysis indicate that alcohol consumption is not a risk factor for the development of sarcopenia. Any suggestion of a putative protective effect of alcohol should be treated with caution, particularly in light of the overall lack of relationship reported in the present comprehensive meta-analysis.PMID:38232346 | DOI:10.1080/00952990.2023.2300049 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 17, 2024 Category: Addiction Authors: Yun-Ling Bu Cao Wang Can Zhao Xiang Lu Wei Gao Source Type: research