Tributaries of the 2023 Nobel Prize in Physiology or Medicine, and Lessons Learned
RNA. 2023 Nov 21:rna.079874.123. doi: 10.1261/rna.079874.123. Online ahead of print.ABSTRACTAlmost without exception, scientific breakthroughs are not epistemological orphans. Historians of science have developed a body of scholarship on this, and the cases arising in our era continue to confirm the phenomenon. The work by Katalin Karikό and Drew Weissman that proved foundational for the subsequent development of mRNA vaccines for Covid-19 had its antecedent roots yet is also a striking example of both serendipity and their persistence. Their receipt of the 2023 Nobel Prize in Physiology or Medicine was greatly deserved a...
Source: RNA - November 21, 2023 Category: Genetics & Stem Cells Authors: Thoru Pederson Source Type: research
Tributaries of the 2023 Nobel Prize in Physiology or Medicine, and Lessons Learned
RNA. 2023 Nov 21:rna.079874.123. doi: 10.1261/rna.079874.123. Online ahead of print.ABSTRACTAlmost without exception, scientific breakthroughs are not epistemological orphans. Historians of science have developed a body of scholarship on this, and the cases arising in our era continue to confirm the phenomenon. The work by Katalin Karikό and Drew Weissman that proved foundational for the subsequent development of mRNA vaccines for Covid-19 had its antecedent roots yet is also a striking example of both serendipity and their persistence. Their receipt of the 2023 Nobel Prize in Physiology or Medicine was greatly deserved a...
Source: RNA - November 21, 2023 Category: Genetics & Stem Cells Authors: Thoru Pederson Source Type: research
Tributaries of the 2023 Nobel Prize in Physiology or Medicine, and Lessons Learned
RNA. 2023 Nov 21:rna.079874.123. doi: 10.1261/rna.079874.123. Online ahead of print.ABSTRACTAlmost without exception, scientific breakthroughs are not epistemological orphans. Historians of science have developed a body of scholarship on this, and the cases arising in our era continue to confirm the phenomenon. The work by Katalin Karikό and Drew Weissman that proved foundational for the subsequent development of mRNA vaccines for Covid-19 had its antecedent roots yet is also a striking example of both serendipity and their persistence. Their receipt of the 2023 Nobel Prize in Physiology or Medicine was greatly deserved a...
Source: RNA - November 21, 2023 Category: Genetics & Stem Cells Authors: Thoru Pederson Source Type: research
Tributaries of the 2023 Nobel Prize in Physiology or Medicine, and Lessons Learned
RNA. 2023 Nov 21:rna.079874.123. doi: 10.1261/rna.079874.123. Online ahead of print.ABSTRACTAlmost without exception, scientific breakthroughs are not epistemological orphans. Historians of science have developed a body of scholarship on this, and the cases arising in our era continue to confirm the phenomenon. The work by Katalin Karikό and Drew Weissman that proved foundational for the subsequent development of mRNA vaccines for Covid-19 had its antecedent roots yet is also a striking example of both serendipity and their persistence. Their receipt of the 2023 Nobel Prize in Physiology or Medicine was greatly deserved a...
Source: RNA - November 21, 2023 Category: Genetics & Stem Cells Authors: Thoru Pederson Source Type: research
Tributaries of the 2023 Nobel Prize in Physiology or Medicine, and Lessons Learned
RNA. 2023 Nov 21:rna.079874.123. doi: 10.1261/rna.079874.123. Online ahead of print.ABSTRACTAlmost without exception, scientific breakthroughs are not epistemological orphans. Historians of science have developed a body of scholarship on this, and the cases arising in our era continue to confirm the phenomenon. The work by Katalin Karikό and Drew Weissman that proved foundational for the subsequent development of mRNA vaccines for Covid-19 had its antecedent roots yet is also a striking example of both serendipity and their persistence. Their receipt of the 2023 Nobel Prize in Physiology or Medicine was greatly deserved a...
Source: RNA - November 21, 2023 Category: Genetics & Stem Cells Authors: Thoru Pederson Source Type: research
< em > RNA < /em > : Reviewers for Volume 29, 2023
RNA. 2023 Dec;29(12):1974-1975.NO ABSTRACTPMID:37973212 | PMC:PMC10653378 (Source: RNA)
Source: RNA - November 16, 2023 Category: Genetics & Stem Cells Source Type: research
Corrigendum: Identification of U < sup > p < /sup > 47 in three thermophilic archaea, one mesophilic archaeon, and one hyperthermophilic bacterium
RNA. 2023 Dec;29(12):1973. doi: 10.1261/rna.079812.123.NO ABSTRACTPMID:37973213 | PMC:PMC10653381 | DOI:10.1261/rna.079812.123 (Source: RNA)
Source: RNA - November 16, 2023 Category: Genetics & Stem Cells Authors: Philippe Wolff Antony Lechner Louis Droogmans Henri Grosjean Eric Westhof Source Type: research
< em > RNA < /em > : Reviewers for Volume 29, 2023
RNA. 2023 Dec;29(12):1974-1975.NO ABSTRACTPMID:37973212 | PMC:PMC10653378 (Source: RNA)
Source: RNA - November 16, 2023 Category: Genetics & Stem Cells Source Type: research
Corrigendum: Identification of U < sup > p < /sup > 47 in three thermophilic archaea, one mesophilic archaeon, and one hyperthermophilic bacterium
RNA. 2023 Dec;29(12):1973. doi: 10.1261/rna.079812.123.NO ABSTRACTPMID:37973213 | PMC:PMC10653381 | DOI:10.1261/rna.079812.123 (Source: RNA)
Source: RNA - November 16, 2023 Category: Genetics & Stem Cells Authors: Philippe Wolff Antony Lechner Louis Droogmans Henri Grosjean Eric Westhof Source Type: research
< em > RNA < /em > : Reviewers for Volume 29, 2023
RNA. 2023 Dec;29(12):1974-1975.NO ABSTRACTPMID:37973212 (Source: RNA)
Source: RNA - November 16, 2023 Category: Genetics & Stem Cells Source Type: research
Corrigendum: Identification of U < sup > p < /sup > 47 in three thermophilic archaea, one mesophilic archaeon, and one hyperthermophilic bacterium
RNA. 2023 Dec;29(12):1973. doi: 10.1261/rna.079812.123.NO ABSTRACTPMID:37973213 | DOI:10.1261/rna.079812.123 (Source: RNA)
Source: RNA - November 16, 2023 Category: Genetics & Stem Cells Authors: Philippe Wolff Antony Lechner Louis Droogmans Henri Grosjean Eric Westhof Source Type: research
Analysis of programmed frameshifting during translation of prfB in Flavobacterium johnsoniae
RNA. 2023 Nov 10:rna.079721.123. doi: 10.1261/rna.079721.123. Online ahead of print.ABSTRACTRibosomes of Bacteroidia fail to recognize Shine-Dalgarno (SD) sequences due to sequestration of the 3' tail of the 16S rRNA on the 30S platform. Yet in these organisms, the prfB gene typically contains the programmed +1 frameshift site with its characteristic SD sequence. Here we investigate prfB autoregulation in Flavobacterium johnsoniae, a member of the Bacteroidia. We find that the efficiency of prfB frameshifting in F. johnsoniae is low (~7%) relative to that in E. coli (~50%). Mutation or truncation of bS21 in F. johnsoniae i...
Source: RNA - November 10, 2023 Category: Genetics & Stem Cells Authors: Fawwaz M Naeem Bryan T Gemler Zakkary A McNutt Ralf Bundschuh Kurt Fredrick Source Type: research
Analysis of programmed frameshifting during translation of prfB in Flavobacterium johnsoniae
RNA. 2023 Nov 10:rna.079721.123. doi: 10.1261/rna.079721.123. Online ahead of print.ABSTRACTRibosomes of Bacteroidia fail to recognize Shine-Dalgarno (SD) sequences due to sequestration of the 3' tail of the 16S rRNA on the 30S platform. Yet in these organisms, the prfB gene typically contains the programmed +1 frameshift site with its characteristic SD sequence. Here we investigate prfB autoregulation in Flavobacterium johnsoniae, a member of the Bacteroidia. We find that the efficiency of prfB frameshifting in F. johnsoniae is low (~7%) relative to that in E. coli (~50%). Mutation or truncation of bS21 in F. johnsoniae i...
Source: RNA - November 10, 2023 Category: Genetics & Stem Cells Authors: Fawwaz M Naeem Bryan T Gemler Zakkary A McNutt Ralf Bundschuh Kurt Fredrick Source Type: research
Analysis of programmed frameshifting during translation of prfB in Flavobacterium johnsoniae
RNA. 2023 Nov 10:rna.079721.123. doi: 10.1261/rna.079721.123. Online ahead of print.ABSTRACTRibosomes of Bacteroidia fail to recognize Shine-Dalgarno (SD) sequences due to sequestration of the 3' tail of the 16S rRNA on the 30S platform. Yet in these organisms, the prfB gene typically contains the programmed +1 frameshift site with its characteristic SD sequence. Here we investigate prfB autoregulation in Flavobacterium johnsoniae, a member of the Bacteroidia. We find that the efficiency of prfB frameshifting in F. johnsoniae is low (~7%) relative to that in E. coli (~50%). Mutation or truncation of bS21 in F. johnsoniae i...
Source: RNA - November 10, 2023 Category: Genetics & Stem Cells Authors: Fawwaz M Naeem Bryan T Gemler Zakkary A McNutt Ralf Bundschuh Kurt Fredrick Source Type: research
Analysis of programmed frameshifting during translation of prfB in Flavobacterium johnsoniae
RNA. 2023 Nov 10:rna.079721.123. doi: 10.1261/rna.079721.123. Online ahead of print.ABSTRACTRibosomes of Bacteroidia fail to recognize Shine-Dalgarno (SD) sequences due to sequestration of the 3' tail of the 16S rRNA on the 30S platform. Yet in these organisms, the prfB gene typically contains the programmed +1 frameshift site with its characteristic SD sequence. Here we investigate prfB autoregulation in Flavobacterium johnsoniae, a member of the Bacteroidia. We find that the efficiency of prfB frameshifting in F. johnsoniae is low (~7%) relative to that in E. coli (~50%). Mutation or truncation of bS21 in F. johnsoniae i...
Source: RNA - November 10, 2023 Category: Genetics & Stem Cells Authors: Fawwaz M Naeem Bryan T Gemler Zakkary A McNutt Ralf Bundschuh Kurt Fredrick Source Type: research
