Ixekizumab Demonstrates Consistent Efficacy Versus Adalimumab in Biologic Disease-Modifying Anti-rheumatic Drug-Na ïve Psoriatic Arthritis Patients Regardless of Psoriasis Severity: 52-Week Post Hoc Results from SPIRIT-H2H
ConclusionsRegardless of baseline psoriasis severity, ixekizumab demonstrated greater efficacy than adalimumab with respect to simultaneous achievement of ACR50 + PASI100, and showed consistent and sustained efficacy across PsA-related domains. It also demonstrated higher response rates for skin outcomes. These subgroup analyses highlight the efficacy of ixekizumab in patients with PsA irrespective of the severity of concomitant psoriasis. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 28, 2021 Category: Rheumatology Source Type: research
Significance of Macrophage Subtypes in the Peripheral Blood of Children with Systemic Juvenile Idiopathic Arthritis
ConclusionsIn the active sJIA, M1 activation promotes inflammation, while M2a rapidly responds to inhibit inflammation; in the inactive sJIA, M2b and M2c play a major role in inhibiting inflammation. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 25, 2021 Category: Rheumatology Source Type: research
Clinical Characteristics of Psoriatic Arthritis in Chinese Patients: A Cross-Sectional Study
ConclusionsPolyarticular involvement was most common in Chinese PsA patients. Ultrasound dramatically increased the identification of peripheral enthesitis. Active PsA patients were more likely to have comorbidities. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 19, 2021 Category: Rheumatology Source Type: research
Patient-Reported Outcomes in Psoriatic Arthritis Patients with an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drugs: SELECT-PsA 2
ConclusionsUpadacitinib provides rapid, clinically meaningful, and sustained improvements in PROs reported by bDMARD-IR PsA patients. SELECT-PsA 2 ClinicalTrials.gov number, NCT03104374. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 18, 2021 Category: Rheumatology Source Type: research
Ultrasound Effectiveness of Steroid Injection for hand Psoriatic Dactylitis: Results from a Longitudinal Observational Study
ConclusionsUS confirmed the effectiveness of steroid injection for dactylitis by demonstrating that it involves the resolution of extra-articular inflammation, in particular FT and STO. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 15, 2021 Category: Rheumatology Source Type: research
