Hyperandrogenism induces proportional changes in the expression of Kiss-1, Tac2, and DynA in hypothalamic KNDy neurons
Kisspeptin released from Kiss-1 neurons in the hypothalamus plays an essential role in the control of the hypothalamic –pituitary–gonadal axis by regulating the release of gonadotropin-releasing hormone (GnRH).... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 21, 2022 Category: Endocrinology Authors: Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride and Satoru Kyo Tags: Research Source Type: research

miR-188-3p-targeted regulation of ATG7 affects cell autophagy in patients with nonobstructive azoospermia
Nonobstructive azoospermia (NOA) is one of the most difficult forms of male infertility to treat, and its pathogenesis is still unclear. miRNAs can regulate autophagy by affecting their target gene expression.... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 16, 2022 Category: Endocrinology Authors: Yuan Wang, Cheng-Cheng Tian, Yun-Yun Jiao, Min-Rui Liu, Xue-Shan Ma, Hai-Xia Jin, Ying-Chun Su, Xiang-Yang Zhang, Wen-Bin Niu, Gui-Don Yao and Wen-Yan Song Tags: Research Source Type: research

The role of insulin-like growth factor 2 mRNA binding proteins in female reproductive pathophysiology
Insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs) family belongs to a highly conserved family of RNA-binding proteins (RBPs) and is responsible for regulating RNA processing including localizati... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 15, 2022 Category: Endocrinology Authors: Xiao Xu, Hao-Ran Shen, Jia-Rong Zhang and Xue-Lian Li Tags: Review Source Type: research

High androgen concentrations in follicular fluid of polycystic ovary syndrome women
According to current definitions of Polycystic Ovary Syndrome (PCOS), hyperandrogenism is considered as a key element in the pathogenesis of this common endocrinopathy. However, until now, studies about ovaria... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 14, 2022 Category: Endocrinology Authors: Alice Bongrani, Ingrid Plotton, Namya Mellouk, Christelle Ram é, Fabrice Guerif, Pascal Froment and Joëlle Dupont Tags: Research Source Type: research

Is letrozole during ovarian stimulation useful in breast cancer patients undergoing fertility preservation to reduce early luteal progesterone levels following GnRH-agonist trigger?
In absence of contraindication, breast cancer patients of reproductive age can undergo fertility preservation with controlled ovarian stimulation for oocyte/embryo cryopreservation before the administration of... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 11, 2022 Category: Endocrinology Authors: Imane Lalami, Julie Labrosse, Isabelle Cedrin-Durnerin, Marjorie Comtet, Claire Vinolas, Fabien Krief, Christophe Sifer, Maeliss Peigne and Michael Grynberg Tags: Research Source Type: research

Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer
To explore the effect of pre-pregnancy body mass index (BMI) on neonatal outcomes among singletons born after frozen embryo transfer (FET). (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 10, 2022 Category: Endocrinology Authors: Jiaying Lin, Haiyan Guo, Bian Wang and Qianqian Zhu Tags: Research Source Type: research

Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis
Women with endometriosis have been shown to have a reduced vagal tone as compared with controls and vagotomy promoted while vagus nerve stimulation (VNS) decelerated the progression of endometriosis in mice. E... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 4, 2022 Category: Endocrinology Authors: Meihua Hao, Xishi Liu and Sun-Wei Guo Tags: Research Source Type: research

MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion
Spontaneous abortions (SA) is amongst the most common complications associated with pregnancy in humans, and the underlying causes cannot be identified in roughly half of SA cases. We found miR-135a-5p to be s... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 24, 2022 Category: Endocrinology Authors: Yebin Lu, Xiaoli Zhang, Xueyu Li, Lingjie Deng, Changqiang Wei, Dongmei Yang, Xuemei Tan, Weicheng Pan and Lihong Pang Tags: Research Source Type: research

Physical activity and sperm quality: influence in sperm donors
To ascertain whether physical activity (PA) is associated with better sperm quality in sperm donors. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 24, 2022 Category: Endocrinology Authors: Roberto Matorras, Alfredo Navarro, Dagoberto Ramos, Iker Malaina, Jon Irazusta, Alberto Vendrell, Amaia Fernandez, Marcos Ferrando and Fernando Quintana Tags: Research Source Type: research

Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells
Ubiquitin-like modifier 1 ligating enzyme 1 (UFL1), the ligase of the UFMylation system, has recently been reported to be involved in apoptosis and endoplasmic reticulum stress (ER stress) in a variety of dise... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 24, 2022 Category: Endocrinology Authors: Xiangting Tang, Hao Dong, Zhi Fang, Jingyi Li, Qi Yang, Ting Yao and Zezheng Pan Tags: Research Source Type: research

Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction
Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key governor of the hypothalamic-pituitary-ovary axis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 23, 2022 Category: Endocrinology Authors: Kai-Lun Hu, Zimiao Chen, Xiaoxue Li, Enci Cai, Haiyan Yang, Yi Chen, Congying Wang, Liping Ju, Wenhai Deng and Liangshan Mu Tags: Review Source Type: research

Betaine attenuate chronic restraint stress-induced changes in testicular damage and oxidative stress in male mice
Male fertility and sperm quality are negatively affected by psychological stress. Chronic restraint stress (CRS) is a common psychological stress that has a negative effect on sperm. Betaine (BET), an active i... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 21, 2022 Category: Endocrinology Authors: Xingqi Meng, Lixuan Peng, Jie Xu, Dongming Guo, Wenyu Cao, Yang Xu and Suyun Li Tags: Research Source Type: research

Characteristics of childhood-onset systemic lupus erythematosus in pregnancy and its association with pregnancy outcomes: a retrospective comparative cohort study
Disease situations are more aggressive in patients with childhood-onset systemic lupus erythematosus (cSLE) than in those with adult-onset SLE (aSLE). However, information on pregnant women with cSLE and its a... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 19, 2022 Category: Endocrinology Authors: Zhi-Ju Li, Hao-Yue Hu, Zi-Ling Ding, Zi-Wei Bian, Ying-Hua Xu, Hui-Ting Wen, Ya-Li Qu, Jin-Dong Wang, Xiao-Li Huang, Dong Li, Jing Li and Gui-Fang Hu Tags: Research Source Type: research

Exosomal AFAP1-AS1 binds to microRNA-15a-5p to promote the proliferation, migration, and invasion of ectopic endometrial stromal cells in endometriosis
Endometriosis (EMS) remains a major challenge to reproductive health due to multifactorial etiology, disease heterogeneity, and the lack of appropriate diagnostic markers and treatment. Eexosome (Exo) has beco... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 5, 2022 Category: Endocrinology Authors: Xi Wang, Mengmeng Zhang, Liaofei Jiang, Xiaoling Fang and Tingting Zhang Tags: Research Source Type: research

Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization
Studies have shown that abnormalities in the decidualization process were closely related to recurrent implantation failure (RIF). Prokineticin 2 (PK2) is a secreted protein with angiogenic and tissue remodeli... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 2, 2022 Category: Endocrinology Authors: Jun Zhai, Linna Ma, Ziyin Chang and Ting Yu Tags: Research Source Type: research