Regulatory Toxicology and Pharmacology : RTP 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Reassessment of the cadmium toxicological reference value for use in human health assessments of foods
Regul Toxicol Pharmacol. 2023 Aug 26;144:105487. doi: 10.1016/j.yrtph.2023.105487. Online ahead of print.ABSTRACTThe U.S. Food and Drug Administration (FDA) developed an oral toxicological reference value (TRV) for characterizing potential health concerns from dietary exposure to cadmium (Cd). The development of the TRV leveraged the FDA's previously published research including (1) a systematic review for adverse health effects associated with oral Cd exposure and (2) a human physiological based pharmacokinetic (PBPK) model adapted from Kjellstrom and Nordberg (1978) for use in reverse dosimetry applied to the U.S. popula...
Source: Regulatory Toxicology and Pharmacology : RTP - August 28, 2023 Category: Toxicology Authors: Heather R Schaefer Brenna M Flannery Lynn M Crosby R égis Pouillot Sofia M Santillana Farakos Jane M Van Doren Sherri Dennis Suzanne Fitzpatrick Karlyn Middleton Source Type: research
Exposure considerations in human safety assessment: Report from an EPAA Partners' Forum
Regul Toxicol Pharmacol. 2023 Aug 26:105483. doi: 10.1016/j.yrtph.2023.105483. Online ahead of print.ABSTRACTUnderstanding and estimating the exposure to a substance is one of the fundamental requirements for safe manufacture and use. Many approaches are taken to determine exposure to substances, mainly driven by potential use and regulatory need. There are many opportunities to improve and optimise the use of exposure information for chemical safety. The European Partnership for Alternative Approaches to Animal Testing (EPAA) therefore convened a Partners' Forum (PF) to explore exposure considerations in human safety asse...
Source: Regulatory Toxicology and Pharmacology : RTP - August 28, 2023 Category: Toxicology Authors: Mark T D Cronin Nicholas Ball Sonja Beken Hans Bender Ofelia Bercaru Laura Caneva Marco Corvaro Richard A Currie Jeffrey L Dawson Paul Desert Sylvia E Escher Antonio Franco Amaia Irizar Jyotigna M Mehta Vera Rogiers Rapha ël T Tremblay Carl Westmoreland Source Type: research
Reassessment of the cadmium toxicological reference value for use in human health assessments of foods
Regul Toxicol Pharmacol. 2023 Aug 26:105487. doi: 10.1016/j.yrtph.2023.105487. Online ahead of print.ABSTRACTThe U.S. Food and Drug Administration (FDA) developed an oral toxicological reference value (TRV) for characterizing potential health concerns from dietary exposure to cadmium (Cd). The development of the TRV leveraged the FDA's previously published research including (1) a systematic review for adverse health effects associated with oral Cd exposure and (2) a human physiological based pharmacokinetic (PBPK) model adapted from Kjellstrom and Nordberg (1978) for use in reverse dosimetry applied to the U.S. population...
Source: Regulatory Toxicology and Pharmacology : RTP - August 28, 2023 Category: Toxicology Authors: Heather R Schaefer Brenna M Flannery Lynn M Crosby R égis Pouillot Sofia M Santillana Farakos Jane M Van Doren Sherri Dennis Suzanne Fitzpatrick Karlyn Middleton Source Type: research
Exposure considerations in human safety assessment: Report from an EPAA Partners' Forum
Regul Toxicol Pharmacol. 2023 Aug 26:105483. doi: 10.1016/j.yrtph.2023.105483. Online ahead of print.ABSTRACTUnderstanding and estimating the exposure to a substance is one of the fundamental requirements for safe manufacture and use. Many approaches are taken to determine exposure to substances, mainly driven by potential use and regulatory need. There are many opportunities to improve and optimise the use of exposure information for chemical safety. The European Partnership for Alternative Approaches to Animal Testing (EPAA) therefore convened a Partners' Forum (PF) to explore exposure considerations in human safety asse...
Source: Regulatory Toxicology and Pharmacology : RTP - August 28, 2023 Category: Toxicology Authors: Mark T D Cronin Nicholas Ball Sonja Beken Hans Bender Ofelia Bercaru Laura Caneva Marco Corvaro Richard A Currie Jeffrey L Dawson Paul Desert Sylvia E Escher Antonio Franco Amaia Irizar Jyotigna M Mehta Vera Rogiers Rapha ël T Tremblay Carl Westmoreland Source Type: research
Reassessment of the cadmium toxicological reference value for use in human health assessments of foods
Regul Toxicol Pharmacol. 2023 Aug 26:105487. doi: 10.1016/j.yrtph.2023.105487. Online ahead of print.ABSTRACTThe U.S. Food and Drug Administration (FDA) developed an oral toxicological reference value (TRV) for characterizing potential health concerns from dietary exposure to cadmium (Cd). The development of the TRV leveraged the FDA's previously published research including (1) a systematic review for adverse health effects associated with oral Cd exposure and (2) a human physiological based pharmacokinetic (PBPK) model adapted from Kjellstrom and Nordberg (1978) for use in reverse dosimetry applied to the U.S. population...
Source: Regulatory Toxicology and Pharmacology : RTP - August 28, 2023 Category: Toxicology Authors: Heather R Schaefer Brenna M Flannery Lynn M Crosby R égis Pouillot Sofia M Santillana Farakos Jane M Van Doren Sherri Dennis Suzanne Fitzpatrick Karlyn Middleton Source Type: research
