Evaluating the efficiency of the 2020 ban of BPA and BPS in thermal papers in Switzerland
This study demonstrates the efficiency of the regulatory measure and the feasibility to substitute BPA in thermal papers with less-toxic alternatives.PMID:37995898 | DOI:10.1016/j.yrtph.2023.105526 (Source: Regulatory Toxicology and Pharmacology : RTP)
Source: Regulatory Toxicology and Pharmacology : RTP - November 23, 2023 Category: Toxicology Authors: Anne-Laure Demierre Hans Reinhard Silvia Zeltner Sabine Frey Source Type: research

Evaluating the efficiency of the 2020 ban of BPA and BPS in thermal papers in Switzerland
This study demonstrates the efficiency of the regulatory measure and the feasibility to substitute BPA in thermal papers with less-toxic alternatives.PMID:37995898 | DOI:10.1016/j.yrtph.2023.105526 (Source: Regulatory Toxicology and Pharmacology : RTP)
Source: Regulatory Toxicology and Pharmacology : RTP - November 23, 2023 Category: Toxicology Authors: Anne-Laure Demierre Hans Reinhard Silvia Zeltner Sabine Frey Source Type: research

The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14;146:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double t...
Source: Regulatory Toxicology and Pharmacology : RTP - November 16, 2023 Category: Toxicology Authors: Michael DeVito Bas Bokkers Majorie B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthe Source Type: research

The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14;146:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double t...
Source: Regulatory Toxicology and Pharmacology : RTP - November 16, 2023 Category: Toxicology Authors: Michael DeVito Bas Bokkers Majorie B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthe Source Type: research

The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14;146:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double t...
Source: Regulatory Toxicology and Pharmacology : RTP - November 16, 2023 Category: Toxicology Authors: Michael DeVito Bas Bokkers Majorie B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthe Source Type: research

The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double the n...
Source: Regulatory Toxicology and Pharmacology : RTP - November 16, 2023 Category: Toxicology Authors: Michael DeVito Bas Bokkers M B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthew W Wh Source Type: research

The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double the n...
Source: Regulatory Toxicology and Pharmacology : RTP - November 16, 2023 Category: Toxicology Authors: Michael DeVito Bas Bokkers M B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthew W Wh Source Type: research

Retrospective analysis of dog study data from food and color additive petitions
Regul Toxicol Pharmacol. 2023 Nov 11:105523. doi: 10.1016/j.yrtph.2023.105523. Online ahead of print.ABSTRACTAs part of the US FDA CFSAN's efforts to explore alternatives to animal testing, we retrospectively analyzed a sample of food additive (FAP) and color additive petitions (CAP) submitted to the FDA for the utility of dog study data in safety assessment. FAPs and CAPs containing dog studies (161 petitions) were classified as decisive (38%), supportive (27%), supplemental (29%) or undermined (6%) based on the impact the dog study had on the final safety decision. Petitions classified as decisive were further categorize...
Source: Regulatory Toxicology and Pharmacology : RTP - November 13, 2023 Category: Toxicology Authors: Brenna M Flannery Alexandra E Turley Njwen Anyangwe Antonia Mattia Catherine Whiteside Steven Hermansky Heather R Schaefer Tina Tyler Suzanne C Fitzpatrick Source Type: research

Retrospective analysis of dog study data from food and color additive petitions
Regul Toxicol Pharmacol. 2023 Nov 11:105523. doi: 10.1016/j.yrtph.2023.105523. Online ahead of print.ABSTRACTAs part of the US FDA CFSAN's efforts to explore alternatives to animal testing, we retrospectively analyzed a sample of food additive (FAP) and color additive petitions (CAP) submitted to the FDA for the utility of dog study data in safety assessment. FAPs and CAPs containing dog studies (161 petitions) were classified as decisive (38%), supportive (27%), supplemental (29%) or undermined (6%) based on the impact the dog study had on the final safety decision. Petitions classified as decisive were further categorize...
Source: Regulatory Toxicology and Pharmacology : RTP - November 13, 2023 Category: Toxicology Authors: Brenna M Flannery Alexandra E Turley Njwen Anyangwe Antonia Mattia Catherine Whiteside Steven Hermansky Heather R Schaefer Tina Tyler Suzanne C Fitzpatrick Source Type: research

Retrospective analysis of dog study data from food and color additive petitions
Regul Toxicol Pharmacol. 2023 Nov 11:105523. doi: 10.1016/j.yrtph.2023.105523. Online ahead of print.ABSTRACTAs part of the US FDA CFSAN's efforts to explore alternatives to animal testing, we retrospectively analyzed a sample of food additive (FAP) and color additive petitions (CAP) submitted to the FDA for the utility of dog study data in safety assessment. FAPs and CAPs containing dog studies (161 petitions) were classified as decisive (38%), supportive (27%), supplemental (29%) or undermined (6%) based on the impact the dog study had on the final safety decision. Petitions classified as decisive were further categorize...
Source: Regulatory Toxicology and Pharmacology : RTP - November 13, 2023 Category: Toxicology Authors: Brenna M Flannery Alexandra E Turley Njwen Anyangwe Antonia Mattia Catherine Whiteside Steven Hermansky Heather R Schaefer Tina Tyler Suzanne C Fitzpatrick Source Type: research

A new paradigm for regulatory sciences
Regul Toxicol Pharmacol. 2023 Nov 2;145:105524. doi: 10.1016/j.yrtph.2023.105524. Online ahead of print.ABSTRACTRegulatory science, rooted in legal requirements, provides a mechanism for identifying, assessing, and managing harm to humans and the environment from exposure to hazardous substances. A challenge for regulatory authorities is that many governing laws reflect the scientific paradigm of the mid-20th century. By the nature of legislative processes, most laws are not able to readily adapt to incorporate scientific advances that are inherent in an ever-evolving paradigm. Consequently, the issue of rigid legal framew...
Source: Regulatory Toxicology and Pharmacology : RTP - November 4, 2023 Category: Toxicology Authors: Gina M Hilton Yadvinder Bhuller John E Doe Douglas C Wolf Richard A Currie Source Type: research

A new paradigm for regulatory sciences
Regul Toxicol Pharmacol. 2023 Nov 2;145:105524. doi: 10.1016/j.yrtph.2023.105524. Online ahead of print.ABSTRACTRegulatory science, rooted in legal requirements, provides a mechanism for identifying, assessing, and managing harm to humans and the environment from exposure to hazardous substances. A challenge for regulatory authorities is that many governing laws reflect the scientific paradigm of the mid-20th century. By the nature of legislative processes, most laws are not able to readily adapt to incorporate scientific advances that are inherent in an ever-evolving paradigm. Consequently, the issue of rigid legal framew...
Source: Regulatory Toxicology and Pharmacology : RTP - November 4, 2023 Category: Toxicology Authors: Gina M Hilton Yadvinder Bhuller John E Doe Douglas C Wolf Richard A Currie Source Type: research

A new paradigm for regulatory sciences
Regul Toxicol Pharmacol. 2023 Nov 2;145:105524. doi: 10.1016/j.yrtph.2023.105524. Online ahead of print.ABSTRACTRegulatory science, rooted in legal requirements, provides a mechanism for identifying, assessing, and managing harm to humans and the environment from exposure to hazardous substances. A challenge for regulatory authorities is that many governing laws reflect the scientific paradigm of the mid-20th century. By the nature of legislative processes, most laws are not able to readily adapt to incorporate scientific advances that are inherent in an ever-evolving paradigm. Consequently, the issue of rigid legal framew...
Source: Regulatory Toxicology and Pharmacology : RTP - November 4, 2023 Category: Toxicology Authors: Gina M Hilton Yadvinder Bhuller John E Doe Douglas C Wolf Richard A Currie Source Type: research

A new paradigm for regulatory sciences
Regul Toxicol Pharmacol. 2023 Nov 2:105524. doi: 10.1016/j.yrtph.2023.105524. Online ahead of print.ABSTRACTRegulatory science, rooted in legal requirements, provides a mechanism for identifying, assessing, and managing harm to humans and the environment from exposure to hazardous substances. A challenge for regulatory authorities is that many governing laws reflect the scientific paradigm of the mid-20th century. By the nature of legislative processes, most laws are not able to readily adapt to incorporate scientific advances that are inherent in an ever-evolving paradigm. Consequently, the issue of rigid legal frameworks...
Source: Regulatory Toxicology and Pharmacology : RTP - November 4, 2023 Category: Toxicology Authors: Gina M Hilton Yadvinder Bhuller John E Doe Douglas C Wolf Richard A Currie Source Type: research

A new paradigm for regulatory sciences
Regul Toxicol Pharmacol. 2023 Nov 2:105524. doi: 10.1016/j.yrtph.2023.105524. Online ahead of print.ABSTRACTRegulatory science, rooted in legal requirements, provides a mechanism for identifying, assessing, and managing harm to humans and the environment from exposure to hazardous substances. A challenge for regulatory authorities is that many governing laws reflect the scientific paradigm of the mid-20th century. By the nature of legislative processes, most laws are not able to readily adapt to incorporate scientific advances that are inherent in an ever-evolving paradigm. Consequently, the issue of rigid legal frameworks...
Source: Regulatory Toxicology and Pharmacology : RTP - November 4, 2023 Category: Toxicology Authors: Gina M Hilton Yadvinder Bhuller John E Doe Douglas C Wolf Richard A Currie Source Type: research