Vascular ageing and peripheral pulse: an improved model for assessing their relationship
Objective. Vascular ageing is associated with several alterations, including arterial stiffness and endothelial dysfunction. Such alterations represent an independent factor in the development of cardiovascular disease (CVD). In our previous works we demonstrated the alterations occurring in the vascular system are themselves reflected in the shape of the peripheral waveform; thus, a model that describes the waveform as a sum of Gaussian curves provides a set of parameters that successfully discriminate between under ( ?35 years old) and over subjects (>35 years old). In the present work, we explored the feasibility ...
Source: Physiological Measurement - December 29, 2021 Category: Physiology Authors: Cosimo Aliani, Eva Rossi, Piergiorgio Francia and Leonardo Bocchi Source Type: research

A supervised machine learning semantic segmentation approach for detecting artifacts in plethysmography signals from wearables
The objective of this study is to develop an effective supervised algorithm to locate the regions of artifacts within PPG signals. Approach . We treat artifact detection as a 1D segmentation problem. We solve it via a novel combination of an active-contour-based loss and an adapted U-Net architecture. The proposed algorithm was trained on the PPG DaLiA training set, and further evaluated on the PPG DaLiA testing set, WESAD dataset and TROIKA dataset. Main results . We evaluated with the DICE score, a well-established metric for segmentation accuracy evaluation in the field of computer vision. The proposed method out...
Source: Physiological Measurement - December 29, 2021 Category: Physiology Authors: Zhicheng Guo, Cheng Ding, Xiao Hu and Cynthia Rudin Source Type: research

From sleep medicine to medicine during sleep
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Source: Physiological Measurement - December 29, 2021 Category: Physiology Authors: Joachim A Behar, Yosi Shamay, Daniel Álvarez, Félix Del Campo and Thomas Penzel Source Type: research

Spectral analysis of heart sounds associated with coronary artery disease
Objective . The aim of this study was to find spectral differences of diagnostic interest in heart sound recordings of patients with coronary artery disease (CAD) and healthy subjects. Approach . Heart sound recordings from three studies were pooled, and patients with clear diagnostic outcomes (positive: CAD and negative: Non-CAD) were selected for further analysis. Recordings from 1146 patients (191 CAD and 955 Non-CAD) were analyzed for spectral differences between the two groups using Welch ’s spectral density estimate. Frequency spectra were estimated for systole and diastole segments, and time-frequency spectr...
Source: Physiological Measurement - November 29, 2021 Category: Physiology Authors: Bjarke Skogstad Larsen, Simon Winther, Louise Nissen, Axel Diederichsen, Morten B øttcher, Johannes Jan Struijk, Mads Græsbøll Christensen and Samuel Emil Schmidt Source Type: research

Automatic cough classification for tuberculosis screening in a real-world environment
We present experiments based on a dataset of 1358 forced cough recordings obtained in a developing-world clinic from 16 patients with confirmed active pulmonary TB and 35 patients suffering from respiratory conditions suggestive of TB but confirmed to be TB negative. Using nested cross-validation, we have trained and evaluated five machine learning classifiers: logistic regression (LR), support vector machines, k-nearest neighbour, multilayer perceptrons and convolutional neural networks. Main Results. Although classification is possible in all cases, the best performance is achieved using LR. In combination with fe...
Source: Physiological Measurement - November 29, 2021 Category: Physiology Authors: Madhurananda Pahar, Marisa Klopper, Byron Reeve, Rob Warren, Grant Theron and Thomas Niesler Source Type: research

Anatomical atlas of the upper part of the human head for electroencephalography and bioimpedance applications
The objective of this work is to develop a 4D (3D+T) statistical anatomical atlas of the electrical properties of the upper part of the human head for cerebral electrophysiology and bioimpedance applications. Approach. The atlas was constructed based on 3D magnetic resonance images (MRI) of 107 human individuals and comprises the electrical properties of the main internal structures and can be adjusted for specific electrical frequencies. T1w+T2w MRI images were used to segment the main structures of the head while angiography MRI was used to segment the main arteries. The proposed atlas also comprises a time-varying...
Source: Physiological Measurement - November 29, 2021 Category: Physiology Authors: Fernando S Moura, Roberto G Beraldo, Leonardo A Ferreira and Samuli Siltanen Source Type: research

Single sensor measurement of heel-height during the push-off phase of gait
Objective . In healthy gait a forceful push-off is needed to get an efficient leg swing and propulsion, and a high heel lift makes a forceful push-off possible. The power of the push-off is decreased with increased age and in persons with impaired balance and gait. The aim of this study was to evaluate whether a wearable equipment (Striton) and algorithms to estimate vertical heel-height during gait from a single optical distance sensor is reliable and feasible for clinical applications. Approach . To assess heel-height with the Striton system an optical distance sensor was used to measure the distance to the floor a...
Source: Physiological Measurement - November 29, 2021 Category: Physiology Authors: Tomas B äcklund, Helena Grip, Fredrik Öhberg and Nina Sundström Source Type: research

Video based non-contact monitoring of respiratory rate and chest indrawing in children with pneumonia
Objective. Pneumonia is the single largest cause of death in children worldwide due to infectious diseases. According to WHO guidelines, fast breathing and chest indrawing are the key indicators of pneumonia in children requiring antibiotic treatments. The aim of this study was to develop a video based novel method for simultaneous monitoring of respiratory rate and chest indrawing without upsetting babies. Approach. Respiratory signals, corresponding to periodic movements of chest-abdominal walls during breathing, were extracted by analyzing RGB (red, green, blue) components in video frames captured by a smartphone ...
Source: Physiological Measurement - November 29, 2021 Category: Physiology Authors: Ferdous Karim Lucy, Khadiza Tun Suha, Sumaiya Tabassum Dipty, Md Sharjis Ibne Wadud and Muhammad Abdul Kadir Source Type: research

Corrigendum: Human microvascular reactivity: a review of vasomodulating stimuli and non-invasive imaging assessment (2021 Physiol. Meas. 42 [http://doi.org/10.1088/1361-6579/ac18fd] 09TR01 )
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Source: Physiological Measurement - November 29, 2021 Category: Physiology Authors: Aaron M Troy and Hai-Ling Margaret Cheng Source Type: research

Photoplethysmography (PPG): state-of-the-art methods and applications
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Source: Physiological Measurement - November 29, 2021 Category: Physiology Authors: John Allen, Dingchang Zheng, Panicos A Kyriacou and Mohamed Elgendi Source Type: research

Tensor electrical impedance myography identifies clinically relevant features in amyotrophic lateral sclerosis
Objective. Electrical impedance myography (EIM) shows promise as an effective biomarker in amyotrophic lateral sclerosis (ALS). EIM applies multiple input frequencies to characterise muscle properties, often via multiple electrode configurations. Herein, we assess if non-negative tensor factorisation (NTF) can provide a framework for identifying clinically relevant features within a high dimensional EIM dataset. Approach. EIM data were recorded from the tongue of healthy and ALS diseased individuals. Resistivity and reactivity measurements were made for 14 frequencies, in three electrode configurations. This gives 84...
Source: Physiological Measurement - November 3, 2021 Category: Physiology Authors: Chl öe N Schooling, T Jamie Healey, Harry E McDonough, Sophie J French, Christopher J McDermott, Pamela J Shaw, Visakan Kadirkamanathan and James J P Alix Source Type: research

Can ionic concentration changes due to mechanical deformation be responsible for the neurostimulation caused by focused ultrasound? A simulation study
Objective. Ultrasound stimulation is an emerging neuromodulation technique, for which the exact mechanism of action is still unknown. Despite the number of hypotheses such as mechanosensitive ion channels and intermembrane cavitation, they fail to explain all of the observed experimental effects. Here we are investigating the ionic concentration change as a prime mechanism for the neurostimulation by the ultrasound. Approach. We derive the direct analytical relationship between the mechanical deformations in the tissue and the electric boundary conditions for the cable theory equations and solve them for two types of...
Source: Physiological Measurement - November 3, 2021 Category: Physiology Authors: Vladimir Filkin, Igor Kuznetsov, Olga Antonova, Ilya Tarotin, Alexander Nemov and Kirill Aristovich Source Type: research

Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
Objective. Breast cancer treatment can negatively impact cardiac function in some breast cancer patients. Current methods (MUGA, echocardiography) used in clinical practice to detect abnormal cardiac changes as a result of treatment suffer from important limitations. Use of alternative techniques that would offer safe, inexpensive and non-invasive cardiac function assessment in this population would be highly advantageous. The aim of this study was to examine the agreement between impedance cardiography (ICG) and cardiac magnetic resonance imaging (CMR) in quantifying stroke volume (SV), cardiac output (CO) and end-d...
Source: Physiological Measurement - November 3, 2021 Category: Physiology Authors: Erifyli Piastopoulou, Parvaiz Ali, Gianfilippo Bertelli, Martyn Heatley, Maung Moe, Chandramohan Murugesan, Gareth Stratton and Michael Lewis Source Type: research

Blood pressure assessment with in-ear photoplethysmography
In this study, we aimed to estimate blood pressure (BP) from in-ear photoplethysmography (PPG). This novel implementation provided an unobtrusive and steady way of recording PPG, whereas previous PPG measurements were mostly performed at the wrist, finger, or earlobe. Methods . The time between forward and reflected PPG waves was very short at the ear site. To minimize errors introduced by feature extraction, a multi-Gaussian decomposition of in-ear PPG was performed. Both hand-crafted and whole-based features were extracted and the best combination of features was selected using a backward-search wrapper method and ...
Source: Physiological Measurement - November 3, 2021 Category: Physiology Authors: Xiaoman Xing, Zhimin Ma, Shengkai Xu, Mingyou Zhang, Wei Zhao, Mingxuan Song and Wen-Fei Dong Source Type: research

Accuracy and applicability of non-invasive evaluation of aortic wave intensity using only pressure waveforms in humans
Background. Wave intensity (WI) analysis is a well-established method for quantifying the energy carried in arterial waves, providing valuable clinical information about cardiovascular function. The primary drawback of this method is the need for concurrent measurements of both pressure and flow waveforms. Objective . We have for the first time investigated the accuracy of a novel methodology for estimating wave intensity employing only single pressure waveform measurements; we studied both carotid- and radial-based estimations in a large heterogeneous cohort. Approach. Tonometry was performed alongside Doppler ultra...
Source: Physiological Measurement - November 3, 2021 Category: Physiology Authors: Arian Aghilinejad, Faisal Amlani, Jing Liu and Niema M Pahlevan Source Type: research