Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets-A Focus on the JAK-STAT Pathway.
Abstract Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also "a disease itself." Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system. This paper provides a summary on pain in inflammatory arthritis, fro...
Source: Pain Research and Management - April 8, 2018 Category: Anesthesiology Authors: Salaffi F, Giacobazzi G, Di Carlo M Tags: Pain Res Manag Source Type: research

Diclofenac Potassium in Acute Postoperative Pain and Dysmenorrhoea: Results from Comprehensive Clinical Trial Reports.
Abstract We compared the efficacy of diclofenac potassium in unpublished clinical study reports (CSRs) and published reports to examine publication bias, industry bias, and comprehensiveness. Novartis provided CSRs of randomised double-blind trials of diclofenac potassium involving postoperative patients following third molar extraction (3 trials, n=519), gynaecological surgery (3 trials, n=679), and dysmenorrhoea (2 trials, n=711) conducted in 1988-1990. Searches identified published reports of 6 trials. Information from 599/1909 patients was not published; trials with 846/1909 patients were published in a defunc...
Source: Pain Research and Management - April 8, 2018 Category: Anesthesiology Authors: Moore RA, Derry S Tags: Pain Res Manag Source Type: research

The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy.
This study determined acute and long-term effects of propofol administration in patients with severe headaches undergoing endoscopic procedures. Background: Approximately 13% of the US population is affected by migraines or severe headaches. The effect of propofol on headaches more than a few days after the intervention has not been explored. Methods: We employed a nonrandomized, prospective observational study that recruited patients with chronic headaches who received propofol from an outpatient endoscopy center for either upper or lower endoscopies. Patients completed the six-item Headache Impact Test (HIT-6) ...
Source: Pain Research and Management - April 5, 2018 Category: Anesthesiology Authors: Giampetro D, Ruiz-Velasco V, Pruett A, Wicklund M, Knipe R Tags: Pain Res Manag Source Type: research

Corrigendum to "Incorporating Family Function into Chronic Pain Disability: The Role of Catastrophizing".
Corrigendum to "Incorporating Family Function into Chronic Pain Disability: The Role of Catastrophizing". Pain Res Manag. 2017;2017:3808520 Authors: Akbari F, Dehghani M, Khatibi A, Vervoort T Abstract [This corrects the article DOI: 10.1155/2016/6838596.]. PMID: 29209137 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - December 8, 2017 Category: Anesthesiology Authors: Akbari F, Dehghani M, Khatibi A, Vervoort T Tags: Pain Res Manag Source Type: research

Effects of Glutathione on Mechanical Allodynia and Central Sensitization in Chronic Postischemic Pain Rats.
Abstract Background: The chronic postischemia pain (CPIP) model is an animal model using ischemia/reperfusion injury that mimics the symptoms of complex regional pain syndrome type I. Glutathione (GSH) prevents ischemia/reperfusion injury by scavenging free radicals. We conducted this study to investigate the protective effect of GSH in CPIP rats via changes of mechanical allodynia and phospholyration of the N-methyl-D-aspartate receptor subunit GluN1. Methods: We divided 45 rats into 5 groups: sham, CPIP, CPIP + GSH 100 mg/kg, CPIP + GSH 200 mg/kg, and CPIP + GSH 500 mg/kg. Rats in the s...
Source: Pain Research and Management - December 8, 2017 Category: Anesthesiology Authors: Yeo J, Jung H, Lee H Tags: Pain Res Manag Source Type: research

Burning Mouth Syndrome: Aetiopathogenesis and Principles of Management.
Abstract Burning mouth syndrome (BMS) is a chronic debilitating oral condition characterised by a burning sensation of the oral mucosa in an otherwise apparently normal person. Its aetiology and pathogenesis are obscure, but both psychogenic factors and peripheral and central neuropathies appear to be implicated. There is no cure for BMS, and treatment with either local or systemic medications focuses on the relief of symptoms and on improving quality of life. In recalcitrant cases, psychological/psychiatric intervention may be helpful. In order to improve treatment outcomes, a better understanding of the pathogen...
Source: Pain Research and Management - November 29, 2017 Category: Anesthesiology Authors: Feller L, Fourie J, Bouckaert M, Khammissa RAG, Ballyram R, Lemmer J Tags: Pain Res Manag Source Type: research

Spinal Cord Stimulation in Failed Back Surgery Syndrome: Effects on Posture and Gait-A Preliminary 3D Biomechanical Study.
Abstract We studied 8 patients with spinal cord stimulation (SCS) devices which had been previously implanted to treat neuropathic chronic pain secondary to Failed Back Surgery Syndrome. The aim of our study was to investigate the effects of SCS on posture and gait by means of clinical scales (Short Form Health Survey-36, Visual Analogue Scale for pain, and Hamilton Depression Rating Scale) and instrumented evaluation with 3D Gait Analysis using a stereophotogrammetric system. The latter was performed with the SCS device turned both OFF and ON. We recorded gait and posture using the Davis protocol and also trunk m...
Source: Pain Research and Management - November 19, 2017 Category: Anesthesiology Authors: Brugliera L, De Luca A, Corna S, Bertolotto M, Checchia GA, Cioni M, Capodaglio P, Lentino C Tags: Pain Res Manag Source Type: research

Single-Needle Arthrocentesis with Upper Compartment Distension versus Conventional Two-Needle Arthrocentesis: Randomized Clinical Trial.
The objective of this study was to compare single-needle arthrocentesis with distension of the upper compartment of the temporomandibular joint (TMJ) with the conventional two-needle arthrocentesis. Twenty-six patients with articular disc displacement without reduction (DDWOR) were included in the study and assigned to two groups (n = 13): single-needle arthrocentesis with distension of the upper compartment of the TMJ (1N) and conventional two-needle arthrocentesis (2N). The maximum interincisal distance (MID) and TMJ pain as measured by the visual analog scale (VAS) were compared. MID and VAS data were obtained: before (...
Source: Pain Research and Management - November 9, 2017 Category: Anesthesiology Authors: Grossmann E, Guilherme Vargas Pasqual P, Poluha RL, Iwaki LCV, Iwaki Filho L, Setogutti ÊT Tags: Pain Res Manag Source Type: research

Clinical Evaluation of a Novel Technology for Oral Patient-Controlled Analgesia, the PCoA ® Acute Device, for Hospitalized Patients with Postoperative Pain, in Pilot Feasibility Study.
Clinical Evaluation of a Novel Technology for Oral Patient-Controlled Analgesia, the PCoA® Acute Device, for Hospitalized Patients with Postoperative Pain, in Pilot Feasibility Study. Pain Res Manag. 2017;2017:7962135 Authors: Wirz S, Conrad S, Shtrichman R, Schimo K, Hoffmann E Abstract Background: Acute postoperative pain delays recovery and increases morbidity and mortality. Traditional administration of postoperative analgesics by nurses is often inefficient. The present study evaluated the safety, efficacy, and usability of a novel, patient-controlled analgesic dispenser, the PCoA Acute. ...
Source: Pain Research and Management - November 3, 2017 Category: Anesthesiology Authors: Wirz S, Conrad S, Shtrichman R, Schimo K, Hoffmann E Tags: Pain Res Manag Source Type: research

Effectiveness of Low-Level Laser Therapy in Reducing Orthodontic Pain: A Systematic Review and Meta-Analysis.
CONCLUSIONS: LLLT proved to be effective in promoting a reduction in spontaneous and chewing pain after the application of OF; however, the poor quality of the evidence requires these results to be treated with caution. PMID: 29089818 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - November 2, 2017 Category: Anesthesiology Authors: Deana NF, Zaror C, Sandoval P, Alves N Tags: Pain Res Manag Source Type: research

Prevalence of Chronic Pain, Treatments, Perception, and Interference on Life Activities: Brazilian Population-Based Survey.
CONCLUSION: 39% of interviewed participants reported chronic pain, with prevalence of females. Gender-associated differences were found in intensity perception and interference of pain on daily life activities. PMID: 29081680 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - November 1, 2017 Category: Anesthesiology Authors: de Souza JB, Grossmann E, Perissinotti DMN, de Oliveira Junior JO, da Fonseca PRB, Posso IP Tags: Pain Res Manag Source Type: research

The Effect of Carpal Tunnel Release on Neuropathic Pain in Carpal Tunnel Syndrome.
Conclusions. The surgery was very effective on NP of CTS; however, the PD in 7% of hands worsened after surgery. Risk factors before surgery that predicted worse NP after surgery were found to be a younger age, weaker pain, and the absence of night pain. PMID: 29081681 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - November 1, 2017 Category: Anesthesiology Authors: Sonohata M, Tsuruta T, Mine H, Asami A, Ishii H, Tsunoda K, Mawatari M Tags: Pain Res Manag Source Type: research

School Anxiety in Children and Adolescents with Chronic Pain.
This article reviews the cooccurrence of pediatric chronic pain and anxiety, identifies unique sources of heightened school anxiety among youth with chronic pain, and describes current approaches for assessing anxiety in pediatric pain settings. Highlighted by this review is the absence of a comprehensive evidence-based approach for assessing school anxiety in pediatric chronic pain. Given the psychometric limitations inherent to gathering data from a single source, recommendations for advancing measurement methods are provided. Novel approaches may be needed to shed more light on the way in which school anxiety is experie...
Source: Pain Research and Management - November 1, 2017 Category: Anesthesiology Authors: Jastrowski Mano KE Tags: Pain Res Manag Source Type: research

Physical Activity May Be Associated with Conditioned Pain Modulation in Women but Not Men among Healthy Individuals.
CONCLUSIONS: These results suggest that, among healthy young individuals, CPM response may be associated with moderate-to-vigorous physical activity in women but not in men. PMID: 29081683 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - November 1, 2017 Category: Anesthesiology Authors: Shiro Y, Ikemoto T, Terasawa Y, Arai YP, Hayashi K, Ushida T, Matsubara T Tags: Pain Res Manag Source Type: research

Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery.
This study compared the efficacy and safety of buprenorphine transdermal system (BTDS) to oral tramadol/acetaminophen (TA) in Korean patients with persistent, moderate pain following spinal surgery. METHODS: Open-label, interventional, randomized multicenter study. Adults with persistent postoperative pain (Numeric Rating Scale [NRS] ≥ 4 at 14-90 days postsurgery) were enrolled. Patients received once-weekly BTDS (n = 47; 5 μg/h titrated to 20 μg/h) or twice-daily TA (n = 40; tramadol 37.5 mg/acetaminophen 325 mg, one tablet titrated to 4 tablets) for 6 weeks. The study compared pa...
Source: Pain Research and Management - October 25, 2017 Category: Anesthesiology Authors: Lee JH, Kim JH, Kim JH, Kim HS, Min WK, Park YS, Lee KY, Lee JH Tags: Pain Res Manag Source Type: research

Effects of Addition of Preoperative Intravenous Ibuprofen to Pregabalin on Postoperative Pain in Posterior Lumbar Interbody Fusion Surgery.
CONCLUSIONS: Multimodal analgesia with preoperative ibuprofen added to preoperative pregabalin safely decreases postoperative pain and total morphine consumption in patients having posterior lumbar interbody fusion surgery, without increasing incidences of bleeding or other side effects. PMID: 28951663 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - September 29, 2017 Category: Anesthesiology Authors: Pınar HU, Karaca Ö, Karakoç F, Doğan R Tags: Pain Res Manag Source Type: research

Spinal Anesthesia and Spinal Anesthesia with Subdiaphragmatic Lidocaine in Shoulder Pain Reduction for Gynecological Laparoscopic Surgery: A Randomized Clinical Trial.
CONCLUSION: The use of subdiaphragmatic lidocaine at the beginning of surgery combined with spinal anesthesia was not associated with a statistically significant difference in patients' postoperative VAS scores compared to spinal anesthesia and GA during and after gynecological surgical procedures. The study was registered in Iranian Registry of Clinical Trial by the number of IRCT2016022226698N1. PMID: 28932131 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - September 23, 2017 Category: Anesthesiology Authors: Asgari Z, Rezaeinejad M, Hosseini R, Nataj M, Razavi M, Sepidarkish M Tags: Pain Res Manag Source Type: research

Central Sensitization-Based Classification for Temporomandibular Disorders: A Pathogenetic Hypothesis.
Abstract Dysregulation of Autonomic Nervous System (ANS) and central pain pathways in temporomandibular disorders (TMD) is a growing evidence. Authors include some forms of TMD among central sensitization syndromes (CSS), a group of pathologies characterized by central morphofunctional alterations. Central Sensitization Inventory (CSI) is useful for clinical diagnosis. Clinical examination and CSI cannot identify the central site(s) affected in these diseases. Ultralow frequency transcutaneous electrical nerve stimulation (ULFTENS) is extensively used in TMD and in dental clinical practice, because of its effects ...
Source: Pain Research and Management - September 23, 2017 Category: Anesthesiology Authors: Monaco A, Cattaneo R, Marci MC, Pietropaoli D, Ortu E Tags: Pain Res Manag Source Type: research

Chronic Pain Assessments in Children and Adolescents: A Systematic Literature Review of the Selection, Administration, Interpretation, and Reporting of Unidimensional Pain Intensity Scales.
CONCLUSIONS: Findings suggest these scales are selected, administered, and interpreted inconsistently, even in studies of the same type. Furthermore, methods of administration are rarely reported or justified making it impossible to compare findings across studies. This article concludes by recommending criteria for the future reporting of paediatric chronic pain assessments in studies. PMID: 28912638 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - September 16, 2017 Category: Anesthesiology Authors: Lee RR, Rashid A, Ghio D, Thomson W, Cordingley L Tags: Pain Res Manag Source Type: research

Comparison of the Perioperative and Postoperative Effects of Levobupivacaine and of Levobupivacaine + Adrenaline in Pediatric Tonsillectomy: A Double-Blind Randomized Study.
CONCLUSIONS: Perioperative levobupivacaine infiltration on its own is a valid alternative to the combination of levobupivacaine + adrenaline for perioperative and postoperative effectiveness in pediatric tonsillectomy. This trial is registered with Australian New Zealand Clinical Trial Registry ACTRN: ACTRN12617001167358. PMID: 28912639 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - September 16, 2017 Category: Anesthesiology Authors: Cicekci F, Sizer C, Atici SS, Arican S, Karaibrahimoglu A, Kara I Tags: Pain Res Manag Source Type: research

Influence of a New "Call-Out Algorithm" for Management of Postoperative Pain and Its Side Effects on Length of Stay in Hospital: A Two-Centre Prospective Randomized Trial.
In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and length of hospital stay (LOS). METHODS: We randomized 1152 surgical patients into three groups for postoperative observation: (1) ESS group (n = 409), (2) Verbal Numeric Rate Scale (VNRS) for pain group (n = 417), and (3) an ordinary qualitative observation (Control) group (n = 326). An ESS> 10 or VNRS> 4 at rest or a nurse's observation of pain or adverse reaction to analgesic treatment in the Control group served as a "call-out alarm"...
Source: Pain Research and Management - September 2, 2017 Category: Anesthesiology Authors: Dybvik L, Skraastad E, Yeltayeva A, Konkayev A, Musaeva T, Zabolotskikh I, Bjertnaes L, Dahl V, Raeder J, Kuklin V Tags: Pain Res Manag Source Type: research

Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update.
Abstract Neuropathic pain is a common phenomenon that affects millions of people worldwide. Maxillofacial structures consist of various tissues that receive frequent stimulation during food digestion. The unique functions (masticatory process and facial expression) of the maxillofacial structure require the exquisite organization of both the peripheral and central nervous systems. Neuralgia is painful paroxysmal disorder of the head-neck region characterized by some commonly shared features such as the unilateral pain, transience and recurrence of attacks, and superficial and shock-like pain at a trigger point. Th...
Source: Pain Research and Management - August 24, 2017 Category: Anesthesiology Authors: Khan M, Nishi SE, Hassan SN, Islam MA, Gan SH Tags: Pain Res Manag Source Type: research

Opioid Prescribing Practices and Training Needs of Qu ébec Family Physicians for Chronic Noncancer Pain.
CONCLUSIONS: This study provides insights into Québec family physicians' concerns, practices, and needs with respect to the management of CNCP. Physicians' difficulties around the application of strategies to mitigate the problem of opioid abuse and addiction are worrying. The need to better train physicians in the field of pain and addiction cannot be emphasized enough. PMID: 28831278 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - August 24, 2017 Category: Anesthesiology Authors: Roy É, Côté RJ, Hamel D, Dubé PA, Langlois É, Labesse ME, Thibault C, Boulanger A Tags: Pain Res Manag Source Type: research

Developing and Implementing a Community-Based Model of Care for Fibromyalgia: A Feasibility Study.
Abstract BACKGROUND: Fibromyalgia (FM) is a complex disease posing challenges for primary care providers and specialists in its management. AIM: To evaluate the development and implementation of a comprehensive, integrated, community-based model of care for FM. METHODS: A mixed methods feasibility study was completed in a small urban centre in southern British Columbia, Canada. Eleven adults with FM and a team of seven health care providers (HCPs) participated in a 10-week intervention involving education, exercise, and sleep management. Monthly "team-huddle" sessions with HCPs facilitated the ...
Source: Pain Research and Management - August 11, 2017 Category: Anesthesiology Authors: Teo M, Mohan B, Oelke ND Tags: Pain Res Manag Source Type: research

Prevalence of Work-Related Musculoskeletal Disorders in the Nurses Working in Hospitals of Xinjiang Uygur Autonomous Region.
CONCLUSIONS: Shift and working/rest duration was closely related to WMSDs. PMID: 28785160 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - August 10, 2017 Category: Anesthesiology Authors: Yan P, Li F, Zhang L, Yang Y, Huang A, Wang Y, Yao H Tags: Pain Res Manag Source Type: research

Pain and Vertebral Dysfunction in Dry Immersion: A Model of Microgravity Simulation Different from Bed Rest Studies.
Abstract BACKGROUND: Astronauts frequently experience back pain during and after spaceflight. The aim of this study was to utilize clinical methods to identify potential vertebral somatic dysfunction (VD) in subjects exposed to dry immersion (DI), a model of microgravity simulation. METHOD: The experiment was performed in a space research clinic, respecting all the ethical rules, with subjects completing three days of dry immersion (n = 11). Assessments of VD, spine height, and back pain were made before and after simulated microgravity. RESULTS: Back pain was present in DI with great global discomfort d...
Source: Pain Research and Management - August 10, 2017 Category: Anesthesiology Authors: Treffel L, Massabuau N, Zuj K, Custaud MA, Gauquelin-Koch G, Blanc S, Gharib C, Millet C Tags: Pain Res Manag Source Type: research

The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism.
CONCLUSION: BTX-A is effective in the treatment of nocturnal bruxism. PMID: 28757802 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - August 1, 2017 Category: Anesthesiology Authors: Asutay F, Atalay Y, Asutay H, Acar AH Tags: Pain Res Manag Source Type: research

Noradrenaline, Serotonin, GABA, and Glycine in Cerebrospinal Fluid during Labor Pain: A Cross-Sectional Prospective Study.
Abstract BACKGROUND AND AIMS: The inhibitory pathways that play a role in spinal modulation include local interneurons and descending control. Clinical data regarding the role of these pathways in acute pain is lacking. Accordingly, the aim of this study was to evaluate cerebrospinal fluid (CSF) levels of noradrenaline, serotonin, gamma-aminobutyric acid (GABA), and glycine in parturients with labor pain compared to those without labor pain. METHODS: One hundred term uncomplicated pregnant women receiving spinal anesthesia for cesarean section were enrolled in this prospective cross-sectional study. CSF norad...
Source: Pain Research and Management - July 15, 2017 Category: Anesthesiology Authors: Chalermkitpanit P, Thonnagith A, Engsusophon P, Charuluxananan S, Honsawek S Tags: Pain Res Manag Source Type: research

A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain.
Abstract BACKGROUND: Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contributing to fear of pain. METHODS: A genome-wide association study (GWAS; N = 990) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain. The total score and three subscales (fear of minor, severe, and medi...
Source: Pain Research and Management - July 15, 2017 Category: Anesthesiology Authors: Randall CL, Wright CD, Chernus JM, McNeil DW, Feingold E, Crout RJ, Neiswanger K, Weyant RJ, Shaffer JR, Marazita ML Tags: Pain Res Manag Source Type: research

Sensitivity, Specificity, Predictive Values, and Accuracy of Three Diagnostic Tests to Predict Inferior Alveolar Nerve Blockade Failure in Symptomatic Irreversible Pulpitis.
lar M, Pozos-Guillén A Abstract INTRODUCTION: The inferior alveolar nerve block (IANB) is the most common anesthetic technique used on mandibular teeth during root canal treatment. Its success in the presence of preoperative inflammation is still controversial. The aim of this study was to evaluate the sensitivity, specificity, predictive values, and accuracy of three diagnostic tests used to predict IANB failure in symptomatic irreversible pulpitis (SIP). METHODOLOGY: A cross-sectional study was carried out on the mandibular molars of 53 patients with SIP. All patients received a single cartridge of m...
Source: Pain Research and Management - July 12, 2017 Category: Anesthesiology Authors: Chavarría-Bolaños D, Rodríguez-Wong L, Noguera-González D, Esparza-Villalpando V, Montero-Aguilar M, Pozos-Guillén A Tags: Pain Res Manag Source Type: research

Cancer Pain Management and Pain Interference with Daily Functioning among Cancer Patients in Gondar University Hospital.
Abstract Cancer is an increasing public health burden for Ethiopia. Pain is among the most common symptoms in patients with cancer. Hence, we aimed to assess cancer pain prevalence, cancer pain interference, and adequacy of cancer pain treatment in the oncology ward of an Ethiopian teaching hospital. Of 83 patients, total of 76 (91.6%) cancer patients experienced pain with varying degree of severity, and 7 (8.4%) patients experienced severe pain. Of the 76 cancer patients with pain, 68 (89.2%) experienced pain interference with their daily activities. Fifty-four (65%) patients were receiving inadequate cancer pain...
Source: Pain Research and Management - July 12, 2017 Category: Anesthesiology Authors: Tegegn HG, Gebreyohannes EA Tags: Pain Res Manag Source Type: research

Acute Postoperative Pain Control.
r C PMID: 28684926 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - July 8, 2017 Category: Anesthesiology Authors: Hancı V, Yurtlu BS, Domi R, Shibata Y, Eyigör C Tags: Pain Res Manag Source Type: research

Immediate Postoperative Pain and Recovery Time after Pulpotomy Performed under General Anaesthesia in Young Children.
Abstract BACKGROUND: The aim of this retrospective study was to compare immediate postoperative pain scores and need for rescue analgesia in children who underwent pulpotomies and restorative treatment and those who underwent restorative treatment only, all under general anaesthesia. METHODS: Ninety patients aged between 3 and 7 years who underwent full mouth dental rehabilitation under general anaesthesia were enrolled in the study and reviewed. The experimental group included patients who were treated with at least one pulpotomy, and the control group was treated with dental fillings only. The Wong-Baker FA...
Source: Pain Research and Management - July 8, 2017 Category: Anesthesiology Authors: Keles S, Kocaturk O Tags: Pain Res Manag Source Type: research

Evaluation of Paracervical Block and IV Sedation for Pain Management during Hysteroscopic Polypectomy: A Randomized Clinical Trial.
CONCLUSION: The finding of the present study revealed that IVS and PB showed the same effect in reducing pain during and after gynecological surgical procedures. The study was registered in Iranian Registry of Clinical Trial with the number IRCT2016031426855N3, on April 28, 2016. PMID: 28676733 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - July 7, 2017 Category: Anesthesiology Authors: Asgari Z, Razavi M, Hosseini R, Nataj M, Rezaeinejad M, Sepidarkish M Tags: Pain Res Manag Source Type: research

Prevalence of Painful Temporomandibular Disorders and Correlation to Lifestyle Factors among Adolescents in Norway.
CONCLUSIONS: A low prevalence of TMD-P was shown but was comparable to other studies. Sex, health, lifestyle, and environment factors were associated with TMD-P. PMID: 28638246 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - June 25, 2017 Category: Anesthesiology Authors: Østensjø V, Moen K, Storesund T, Rosén A Tags: Pain Res Manag Source Type: research

A Clinical Prospective Observational Cohort Study on the Prevalence and Primary Diagnostic Accuracy of Occult Vertebral Fractures in Aged Women with Acute Lower Back Pain Using Magnetic Resonance Imaging.
CONCLUSIONS: Acute LBP patients may suffer vertebral injury with almost no morphologic change in X-ray, which can be detected using MRI. PMID: 28630567 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - June 22, 2017 Category: Anesthesiology Authors: Terakado A, Orita S, Inage K, Kubota G, Kanzaki T, Mori H, Shinohara Y, Nakamura J, Matsuura Y, Aoki Y, Furuya T, Koda M, Ohtori S Tags: Pain Res Manag Source Type: research

Effect of Ice Bag Application to Femoral Region on Pain in Patients Undergoing Percutaneous Coronary Intervention.
GN, Oguzhan A Abstract AIMS: The aim of this study is to determine the pain reduction effectiveness of ice bag applications to the femoral region in patients undergoing percutaneous coronary intervention. MATERIAL AND METHODS: A randomized controlled trial with repeated measures and two-group design. The study was completed with a total of 104 patients who met the inclusion criteria: 52 each in the experimental group and the control group. The pain experienced by the patients was evaluated before and during removal and again while the nurse applied pressure on the catheter site after removal. The NRS scores w...
Source: Pain Research and Management - June 22, 2017 Category: Anesthesiology Authors: Bayındır SK, Çürük GN, Oguzhan A Tags: Pain Res Manag Source Type: research

Differences in Multidisciplinary and Interdisciplinary Treatment Programs for Fibromyalgia: A Mapping Review.
The objective of this mapping review was to summarize the characteristics of these programs, with particular focus on the integration of their components. We performed a search of the literature about treatments for fibromyalgia involving multiple disciplines on PubMed and Scopus. Starting from 560 articles, we included 22 noncontrolled studies, 10 controlled studies, and 17 RCTs evaluating the effects of 38 multidisciplinary or interdisciplinary interventions. The average quality of the studies was low. Their outcomes were usually pain intensity, quality of life, and psychological variables. We created a map of the progra...
Source: Pain Research and Management - June 18, 2017 Category: Anesthesiology Authors: Giusti EM, Castelnuovo G, Molinari E Tags: Pain Res Manag Source Type: research

Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial.
CONCLUSIONS: Although underpowered, this study demonstrates a clinically important analgesic signal. TTX may provide clinically meaningful analgesia for patients who have persistent moderate to severe cancer pain despite best analgesic care. This clinical study is registered with ClinicalTrials.gov (NCT00725114). PMID: 28555092 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - June 1, 2017 Category: Anesthesiology Authors: Hagen NA, Cantin L, Constant J, Haller T, Blaise G, Ong-Lam M, du Souich P, Korz W, Lapointe B Tags: Pain Res Manag Source Type: research

Effectiveness of Hypnosis in Combination with Conventional Techniques of Behavior Management in Anxiety/Pain Reduction during Dental Anesthetic Infiltration.
Conclusion. Hypnosis combined with conventional behavior management techniques decreases heart rate during anesthetic infiltration showing that there may be an improvement in anxiety/pain control through hypnotic therapy. PMID: 28490941 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - May 13, 2017 Category: Anesthesiology Authors: Ramírez-Carrasco A, Butrón-Téllez Girón C, Sanchez-Armass O, Pierdant-Pérez M Tags: Pain Res Manag Source Type: research

Comparison of Incidences of Intravascular Injection between Medial and Lateral Side Approaches during Traditional S1 Transforaminal Epidural Steroid Injection.
Abstract Purpose. Intravascular injection rates are higher during traditional S1 transforaminal epidural steroid injection (TFESI) compared with lumbar transforaminal injection. We compared the incidences of intravascular injection between the medial and lateral approaches to the S1 foramen during S1 TFESI. Materials and Methods. A total of 139 patients underwent one or more TFESIs (170 total injections). The patients received S1 TFESI by either medial or lateral side of S1 foramen under fluoroscopic anteroposterior view using digital subtraction method. The intravascular injection rates, epidural spread patterns,...
Source: Pain Research and Management - May 13, 2017 Category: Anesthesiology Authors: Park SJ, Kim SH, Kim SJ, Yoon DM, Yoon KB Tags: Pain Res Manag Source Type: research

The Effect of Peritubal Infiltration with Bupivacaine and Morphine on Postoperative Analgesia in Patients Undergoing Percutaneous Nephrolithotomy.
Conclusion. Our study results suggest that peritubal infiltration of bupivacaine with morphine after percutaneous nephrolithotomy is an effective method for postoperative pain control and reduces analgesic consumption. PMID: 28484316 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - May 10, 2017 Category: Anesthesiology Authors: Karaduman I, Karasu D, Yilmaz C, Oner S, Erdem Solak H, Korfali G Tags: Pain Res Manag Source Type: research

The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines.
We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α). Methods. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. Results. LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups a...
Source: Pain Research and Management - May 6, 2017 Category: Anesthesiology Authors: Chia YY, Liu CC, Feng GM, Tseng CA, Hung KC, Chen CC, Tan PH Tags: Pain Res Manag Source Type: research

Developing a Sense of Knowing and Acquiring the Skills to Manage Pain in Children with Profound Cognitive Impairments: Mothers' Perspectives.
Abstract Children with profound cognitive impairment (PCI) are a heterogenous group who often experience frequent and persistent pain. Those people closest to the child are key to assessing their pain. This mixed method study aimed to explore how parents acquire knowledge and skills in assessing and managing their child's pain. Eight mothers completed a weekly pain diary and were interviewed at weeks 1 and 8. Qualitative data were analysed using thematic analysis and the quantitative data using descriptive statistics. Mothers talked of learning through a system of trial and error ("learning to get on with it&...
Source: Pain Research and Management - May 3, 2017 Category: Anesthesiology Authors: Carter B, Arnott J, Simons J, Bray L Tags: Pain Res Manag Source Type: research

Patient Perception of Acute Pain Management: Data from Three Tertiary Care Hospitals.
Abstract Introduction. The primary objectives of this study were to assess patients' description of their acute pain intensity; patients' attitude towards their pain management during hospitalization; and their overall satisfaction with pain treatment. Methodology. A cross-sectional questionnaire-based study was conducted between October 2014 and March 2015 in three medical centers in Lebanon. All participants' responses were reported using descriptive statistics. The association between categorical variables was evaluated using Pearson χ(2) test or Fisher's exact test where the expected cell count was
Source: Pain Research and Management - May 3, 2017 Category: Anesthesiology Authors: Ramia E, Nasser SC, Salameh P, Saad AH Tags: Pain Res Manag Source Type: research

Intravenous Lidocaine: Old-School Drug, New Purpose-Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy.
Conclusion. Iv lidocaine has direct analgesic effect in CIPN with a moderate long-term effect and seems to influence the area of cold and pinprick perception. Additional research is needed, using a control group and larger sample sizes to confirm these results. PMID: 28458593 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - May 3, 2017 Category: Anesthesiology Authors: van den Heuvel SAS, van der Wal SEI, Smedes LA, Radema SA, van Alfen N, Vissers KCP, Steegers MAH Tags: Pain Res Manag Source Type: research

Temporomandibular Disorders and Headache: A Retrospective Analysis of 1198 Patients.
Conclusion. This study is consistent with previous literature in showing a close relationship between headache and TMD. All data underlines that headache makes pain parameters more intense and frequent. Therefore, an early and multidisciplinary treatment of TMDs should be performed in order to avoid the overlay of painful events that could result in pain chronicity. PMID: 28420942 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - April 22, 2017 Category: Anesthesiology Authors: Di Paolo C, D'Urso A, Papi P, Di Sabato F, Rosella D, Pompa G, Polimeni A Tags: Pain Res Manag Source Type: research

Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats.
Conclusions. These findings may improve the knowledge about the involvement of astrocytes, microglia, and BDNF in the chronic pain and show that NM treatment, which alleviates neuropathic pain, affects glial cells and BDNF expression. PMID: 28420943 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - April 22, 2017 Category: Anesthesiology Authors: Giardini AC, Dos Santos FM, da Silva JT, de Oliveira ME, Martins DO, Chacur M Tags: Pain Res Manag Source Type: research

Periodontal Status and Quality of Life: Impact of Fear of Pain and Dental Fear.
Abstract Background. Oral health-related quality of life (OHRQoL) is impacted by periodontal disease and orofacial pain. There is a limited research examining the impact of avoidance of care or physiological arousal related to the fear of pain response on periodontal-related OHRQoL. Methods. Data are from the Center for Oral Health Research in Appalachia family-based study focusing on 1,339 adults. Measures included a modified Periodontal Screening and Recording Index across sextants of dentition, dental fear survey, Fear of Pain Questionnaire-9, and Oral Health Impact Profile-14. Structural equation modeling was ...
Source: Pain Research and Management - April 6, 2017 Category: Anesthesiology Authors: Wright CD, McNeil DW, Edwards CB, Crout RJ, Neiswanger K, Shaffer JR, Marazita ML Tags: Pain Res Manag Source Type: research

Gabapentin Does Not Appear to Improve Postoperative Pain and Sleep Patterns in Patients Who Concomitantly Receive Regional Anesthesia for Lower Extremity Orthopedic Surgery: A Randomized Control Trial.
man S Abstract In recent years, gabapentin has gained popularity as an adjuvant therapy for the treatment of postoperative pain. Numerous studies have shown a decrease in pain score, even with immediate postoperative activity, which is significant for early post-op ambulation and regaining functionality sooner. However, studies have been in conclusive in patients undergoing lower extremity orthopedic surgery. For this reason, we hoped to study the effect of gabapentin on postoperative pain in patients undergoing total knee arthroplasty, total hip arthroplasty, or a hip fracture repair. This was done in the setting...
Source: Pain Research and Management - March 31, 2017 Category: Anesthesiology Authors: Eloy JD, Anthony C, Amin S, Caparó M, Reilly MC, Shulman S Tags: Pain Res Manag Source Type: research