SPAK and OSR1 Sensitive Kir2.1 K < sup > + < /sup > Channels
Conclusions: < /i > < /b > SPAK and OSR1 are both stimulators of Kir2.1 activity. They are presumably effective by enhancing channel insertion into the cell membrane. < br / > Neurosignals 2015;23:20-33 (Source: Neurosignals)
Source: Neurosignals - July 22, 2016 Category: Neurology Source Type: research
Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System
Conclusion: These data indicate that the antidepressive effects of melatonin as well as the induction of neurogenesis triggered by this drug are mediated by an inhibition of the acid sphingomyelinase/ceramide system. This is the first study to identify melatonin as an inhibitor of the acid sphingomyelinase.Neurosignals 2016;24:48-58 (Source: Neurosignals)
Source: Neurosignals - July 12, 2016 Category: Neurology Source Type: research
Wnt / ß-Catenin Signaling Pathway Against Aβ Toxicity in PC12 Cells
Conclusion: These findings are first to demonstrate that Wnt/β-catenin signaling pathway regulates Aβ25-35-induced apoptosis.Neurosignals 2016;24:40-47 (Source: Neurosignals)
Source: Neurosignals - June 17, 2016 Category: Neurology Source Type: research
Nogo-p4 Suppresses TrkA Signaling Induced by Low Concentrations of Nerve Growth Factor Through NgR1 in Differentiated PC12 Cells
Conclusion: Nogo-p4 binding with NgR1 suppresses TrkA signaling induced by low concentrations of NGF in differentiated PC12 cells. Suppression of NGF-induced TrkA signaling may be another mechanism by which Nogo inhibits neurite growth.Neurosignals 2016;24:25-39 (Source: Neurosignals)
Source: Neurosignals - June 14, 2016 Category: Neurology Source Type: research
Early Postoperative Nociceptive Threshold and Production of Brain-Derived Neurotrophic Factor Induced by Plantar Incision Are Not Influenced with Minocycline in a Rat: Role of Spinal Microglia
Conclusion: These results suggest that spinal microglia does not contribute substantially to post-incisional nociceptive threshold. The BDNF overexpression response that may contribute to postoperative hyperalgesia and allodynia is likely derived from other sources.Neurosignals 2016;24:15-24 (Source: Neurosignals)
Source: Neurosignals - March 3, 2016 Category: Neurology Source Type: research
Role of Serum Brain Derived Neurotrophic Factor and Central N-Acetylaspartate for Clinical Response under Antidepressive Pharmacotherapy
Conclusion: Our data confirm serum BDNF as a biomarker of depression with a possible role in response prediction. However, our findings argue against serum BDNF increase being a prerequisite to depressive symptom reduction.Neurosignals 2016;24:1-14 (Source: Neurosignals)
Source: Neurosignals - February 10, 2016 Category: Neurology Source Type: research
Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression
Conclusion: Stress induces p38K phosphorylation/activation in the hippocampus and thereby reduces neurogenesis and induces depression-like symptoms, events that are prevented by antidepressants via inhibition of the acid sphingomyelinase/ceramide system.Neurosignals 2015;23:84-92 (Source: Neurosignals)
Source: Neurosignals - December 18, 2015 Category: Neurology Source Type: research
Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology
Conclusion: This study revealed increased FA and decreased MD in early stages of psychosis in widespread white matter tracts including the SLF. Our findings further suggest that microstructural changes in the SLF are probably related to state-dependent psychopathology.Neurosignals 2015;23:71-83 (Source: Neurosignals)
Source: Neurosignals - December 18, 2015 Category: Neurology Source Type: research
Up-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by ß-Klotho
Conclusion: ß-Klotho up-regulates the excitatory glutamate transporters EAAT1 and EAAT2 and thus participates in the regulation of neuronal excitation.Neurosignals 2015;23:59-70 (Source: Neurosignals)
Source: Neurosignals - December 18, 2015 Category: Neurology Source Type: research
Sphingolipids in Major Depression
Major depression is one of the most common and severe diseases affecting the world's population. However, the pathogenesis of the disease remains inadequately defined. Previously, a lack of monoaminergic neurotransmitters was the focus of pathophysiological concepts; however, recent concepts focus on a alteration of neurogenesis in the hippocampus. This concept suggests that neurogenesis is decreased in major depression with a rarefication of neuronal networks and a lack of new, immature neurons in the hippocampus, events that may result in the clinical symptoms of major depression. However, molecular targets involved in t...
Source: Neurosignals - December 18, 2015 Category: Neurology Source Type: research
Lithium- Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release
Conclusion: Lithium stimulates FGF23 release at least in part by NF-#x03BA;B dependent up-regulation of Orai1 transcription and store operated Ca2+ entry.Neurosignals 2015;23:34-48 (Source: Neurosignals)
Source: Neurosignals - December 16, 2015 Category: Neurology Source Type: research
SPAK and OSR1 Sensitive Kir2.1 K+ Channels
Conclusions: SPAK and OSR1 are both stimulators of Kir2.1 activity. They are presumably effective by enhancing channel insertion into the cell membrane.Neurosignals 2015;23:20-33 (Source: Neurosignals)
Source: Neurosignals - December 16, 2015 Category: Neurology Source Type: research
Regulation of the Na+,Cl- Coupled Creatine Transporter CreaT (SLC6A8) by the Janus Kinase JAK3
Conclusion: JAK3 is a powerful negative regulator of the creatine transporter CreaT.Neurosignals 2015;23:11-19 (Source: Neurosignals)
Source: Neurosignals - December 14, 2015 Category: Neurology Source Type: research
Chorein Sensitive Dopamine Release from Pheochromocytoma (PC12) Cells
Conclusions: Chorein deficiency down-regulates VAMP8 expression, vesicle numbers and dopamine release in pheochromocytoma cells.Neurosignals 2015;23:1-10 (Source: Neurosignals)
Source: Neurosignals - December 11, 2015 Category: Neurology Source Type: research
Electrophysiological Features of Neurons in the Mesencephalic Trigeminal Nuclei
Mesencephalic trigeminal nucleus (Mes V) neurons represent an uncommon class of primary sensory neurons. Besides receiving somatosensory information, Mes V neurons are also involved in regulating multisensory information. The present review first describes the passive features as well as three important currents, followed by a distinct excitability classification and a description of the excitability transition of Mes V neurons. Furthermore, their resonance property, the existence of membrane oscillation and electrical coupling which may promote strong synchronization, as well as their function in controlling stretch refle...
Source: Neurosignals - January 8, 2015 Category: Neurology Source Type: research
