Introducing a Virtual Lesion Model of Dysphagia Resulting from Pharyngeal Sensory Impairment
Conclusions: Withdrawal of sensory afferent information by topical anesthesia leads to reduced response to pneumatic pharyngeal stimulation in a distributed cortical sensorimotor network in healthy subjects. The proposed paradigm may serve to investigate the effect of neuromodulatory treatments specifically on pharyngeal sensory impairment as relevant cause of neurogenic dysphagia.Neurosignals 2018;26:1 –10 (Source: Neurosignals)
Source: Neurosignals - January 24, 2018 Category: Neurology Source Type: research

Decreased Fronto-Parietal and Increased Default Mode Network Activation is Associated with Subtle Cognitive Deficits in Elderly Controls
Conclusion: The present study suggests that brain functional changes in FPN and DMN anticipate differences in cognitive performance in healthy elderly individuals with subsequent subtle cognitive decline.Neurosignals 2017;25:127 –138 (Source: Neurosignals)
Source: Neurosignals - December 21, 2017 Category: Neurology Source Type: research

Neurons, Erythrocytes and Beyond –The Diverse Functions of Chorein
In conclusion, much has been learned about the function of chorein and the molecular pathophysiology of chorea-acanthocytosis. Most importantly, a treatment halting or delaying the clinical course of this devastating disease may become available. A controlled clinical study is warranted, in order to explore whether thein vitro observations indeed reflect thein vivo pathology of the disease.Neurosignals 2017;25:117 –126 (Source: Neurosignals)
Source: Neurosignals - November 28, 2017 Category: Neurology Source Type: research

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics
Endomorphin-1 (EM1) and endomorphin-2 (EM2) are two endogenous ligands that belong to the opioid peptide family and have the highest affinity and selectivity for the µ-opioid receptor (MOR). The neuroanatomical distribution, ultrastructural features and neural circuitry of EM-containing neuronal structures have been morphologically demonstrated. In addition, the modulation effects of the EMs in different areas reflect their potential endogenous roles in many ma jor physiological processes, including their remarkable roles in the transmission and modulation of noxious information. The distinguished antinociceptive property...
Source: Neurosignals - November 13, 2017 Category: Neurology Source Type: research

Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System
Conclusion: Activation of the Asm/ceramide system is a central step for the development of EAE. Our findings may serve to identify novel therapeutic strategies for MS patients.Neurosignals 2017;25:88 –97 (Source: Neurosignals)
Source: Neurosignals - November 7, 2017 Category: Neurology Source Type: research

Leptin-Sensitive JAK2 Activation in the Regulation of Tau Phosphorylation in PC12 Cells
Conclusion:The data suggest that JAK2 is involved in AD-related pathways.Neurosignals 2016;24:88-94 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

Leptin Regulates Tau Phosphorylation through Wnt Signaling Pathway in PC12 Cells
Conclusion:The data indicate that Leptin may provide a novel therapeutic approach to AD treatment via wnt signaling.Neurosignals 2016;24:95-101 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

Cortical Responses and Shape Complexity of Stereoscopic Image - A Simultaneous EEG/MEG Study
Conclusion:It seems that the relative disparity in complex stereoscopic images may increase cognitive processing (N300) and cortical load (alpha inhibition) in the ventral area.Neurosignals 2016;24:102-112 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

SGK3 Sensitivity of Large-Conductance Ca < sup > 2+ < /sup > -Activated K < sup > + < /sup > Channel
Conclusion: SGK3 is a novel positive regulator of BK channels, and thus participates in the regulation of cell volume and excitability.Neurosignals 2016;24:113-124 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

Improved Neural Regeneration with Olfactory Ensheathing Cell Inoculated PLGA Scaffolds in Spinal Cord Injury Adult Rats
Conclusion: PLGA complexes inoculated with OECs improve locomotor functional recovery in transected spinal cord injured rat models, which is most likely due to the fact it is conducive to a relatively benevolent microenvironment, has nerve protective effects, as well as the ability to enhance remyelination, via a promotion of cell differentiation and inhibition of astrocyte formation.Neurosignals 2017;25:1 –14 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

The Spatial Extent of Epiretinal Electrical Stimulation in the Healthy Mouse Retina
Conclusion: The existence of significant hysteresis requires that future investigations of electrical retinal stimulation control for such long-memory adaptation. The spread of electrical activation beyond 200 µm suggests that neighbouring electrodes in epiretinal implants based on indirect stimulation of RGCs may be indiscriminable at interelectrode spacings as large as 400 µm.Neurosignals 2017;25:15 –25 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells
Conclusion: These data serve as proof of principle that Kv1.3 inhibitors kills GBM cells, but drugs that actin vivo against glioblastoma must be developed to translate these findingsin vivo.Neurosignals 2017;25:26 –38 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

Stimulation of Anxiety-Like Behavior via ERK Pathway by Competitive Serotonin Receptors 2A and 1A in Post-Traumatic Stress Disordered Mice
Conclusion: These findings suggest competive interaction between 5HT2AR and 5HT1AR actively affects anxiety-like behavior in the hippocampi of PTSD mice via the ERK pathway.Neurosignals 2017;25:39 –53 (Source: Neurosignals)
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research