Potential arrhythmic substrate of atrial fibrillation at the left atrial diverticulum
Nagoya J Med Sci. 2024 Feb;86(1):142-148. doi: 10.18999/nagjms.86.1.142.ABSTRACTCatheter ablation therapy for persistent atrial fibrillation (PeAF) is both difficult and has limited outcomes. The mechanisms underlying the development and persistence of atrial fibrillation (AF) are not fully understood; therefore, ablation strategies are diverse. A 45-year-old man was referred to our hospital for persistent atrial fibrillation to undergo radiofrequency catheter insertion (RFCA). In the first session we conducted pulmonary vein isolation and additional linear ablation, including that of the roof line and posterior inferior l...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Takehiko Takayanagi Source Type: research
Diseases categorized as autoinflammatory keratinization diseases (AiKDs), and their pathologies and treatments
Nagoya J Med Sci. 2024 Feb;86(1):1-15. doi: 10.18999/nagjms.86.1.1.ABSTRACTWhole-exome and whole-genome sequencing have become widespread in approximately the last 15 years, and the predisposing factors and pathomechanisms of inflammatory keratinization diseases, which have been unknown for a long time, have gradually been revealed. Hence, various inflammatory keratinization diseases are recognized to cause innate immunity hyperactivation. Therefore, we have been advocating for the clinical entity, "autoinflammatory keratinization diseases (AiKDs)" since 2017. AiKDs are inflammatory keratinization diseases caused by autoin...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Masashi Akiyama Source Type: research
Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities
We report a case of a preterm infant with congenital cytomegalovirus infection complicated with 22q11.2 deletion syndrome and immunological abnormalities. Ultrasonography revealed pulmonary atresia, ventricular septal defect, major aortopulmonary collateral artery, and thymic hypoplasia. His serum chemistry tests on admission revealed immunoglobulin G, A, and M levels of 1,547 mg/dL, 70 mg/dL, and 274 mg/dL, respectively. A surface antigen analysis of the peripheral lymphocytes using flow cytometry revealed the following: relatively low CD4-positive T-cell levels (18.1%; 1,767/μL), very high CD8-positive T-cell levels (58...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Yoshihiko Shitara Etsushi Toyofuku Hideki Doi Takeo Mukai Kohei Kashima Satsuki Kakiuchi Motohiro Kato Naoto Takahashi Source Type: research
Seven-year follow-up of endovascular treatment of iatrogenic brachioradial artery injury complicating percutaneous coronary intervention: a case report
Nagoya J Med Sci. 2024 Feb;86(1):155-159. doi: 10.18999/nagjms.86.1.155.ABSTRACTThe radial artery has been used increasingly for percutaneous coronary intervention because of its safety and feasible access route. Nevertheless, transradial complications are possible because of the variation in radial artery anatomy. We experienced a case of the brachioradial artery injury secondary to catheterization, presenting as hypovolemic shock. A 76-year-old woman presented at our emergency department complaining of effort-induced angina. Coronary angiography via the right radial artery showed critical stenosis in the middle of the le...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Hyeon Wook Kim Sung Soo Kim Hyun Kuk Kim Young Jae Ki Keun Ho Park Dong Hyun Choi Source Type: research
＜Editors' Choice＞ Thoracic endovascular aortic repair and spinal cord injury
Nagoya J Med Sci. 2024 Feb;86(1):16-23. doi: 10.18999/nagjms.86.1.16.ABSTRACTWe previously reported that spinal cord injury following thoracic endovascular aortic repair for a thoracic aortic aneurysm is a micro embolism caused by a vulnerable mural thrombus. Conversely, patients who underwent thoracic endovascular aortic repair for aortic dissection develop spinal cord injury less frequently due to fewer mural thrombi. Paying attention to preserving blood flow toward the spinal cord, namely collateral circulation and steal phenomenon, prevents spinal cord injury following thoracic endovascular aortic repair for aortic dis...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Hiroshi Banno Changi Lee Shuta Ikeda Yohei Kawai Masayuki Sugimoto Kiyoaki Niimi Source Type: research
