Involvement of microRNA-4680-3p against phenytoin-induced cell proliferation inhibition in human palate cells
J Toxicol Sci. 2024;49(1):1-8. doi: 10.2131/jts.49.1.ABSTRACTCleft palate (CP) is one of the most common birth defects and is caused by a combination of genetic and/or environmental factors. Environmental factors such as pharmaceutical exposure in pregnant women are known to induce CP. Recently, microRNA (miRNA) was found to be affected by environmental factors. The aim of the present study was to investigate the involvement of miRNA against phenytoin (PHE)-induced inhibition of proliferation in human embryonic palatal mesenchymal (HEPM) cells. We demonstrated that PHE inhibited HEPM cell proliferation in a dose-dependent ...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Yosuke Tsukiboshi Hanane Horita Yurie Mikami Azumi Noguchi Satoshi Yokota Kenichi Ogata Hiroki Yoshioka Source Type: research
Industrially produced trans-fatty acids are potent promoters of DNA damage-induced apoptosis
J Toxicol Sci. 2024;49(1):27-36. doi: 10.2131/jts.49.27.ABSTRACTtrans-Fatty acids (TFAs) are unsaturated fatty acids harboring at least one carbon-carbon double bond in trans configuration, which are categorized into two groups according to their origin: industrial and ruminant TFAs, hereafter called iTFAs and rTFAs, respectively. Numerous epidemiological studies have shown a specific link of iTFAs to various diseases, such as cardiovascular and neurodegenerative diseases. However, there is little evidence for underlying mechanisms that can explain the specific toxicity of iTFAs, and how to mitigate their toxicity. Herein,...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Yusuke Hirata Ryota Kojima Ryo Ashida Yuki Nada Shinnosuke Kimura Emiko Sato Takuya Noguchi Atsushi Matsuzawa Source Type: research
Paternal methamphetamine exposure differentially affects first and second generations in mice
J Toxicol Sci. 2024;49(1):9-26. doi: 10.2131/jts.49.9.ABSTRACTAmphetamine-type stimulants are abused worldwide, and methamphetamine (METH) accounts for a large majority of seized abused drug cases. Recently, the paternal origin of health and disease theory has been proposed as a concept wherein paternal factors influence descendants. Although METH abuse is more common among males, its effects on their descendants were not examined. Therefore, we investigated the effects of paternal METH exposure on F1 and F2 levels in a mouse model. Sires were administered METH for 21 days and mated with female mice to obtain F1 mice. Grow...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Sakiko Munetomo-Aoki Asuka Kaizaki-Mitsumoto Ryota Nakano Satoshi Numazawa Source Type: research
Development of a risk assessment method for the detailed consideration of the effects of liquid toxic substance leakage incidents on the human body: ethanol as a model substance
In this study, a risk assessment method was developed for the problem of the leakage of liquid hazardous substances. The risk assessment of toxic liquid leaks must consider the exposure of workers to the liquid and toxic gases produced by vaporization. The absorption and subsequent metabolism of hazardous substances in the body via multiple pathways after exposure to liquids and gases was calculated using a pharmacokinetic model. Estimation of exposure concentrations of toxic gases volatilized from leaked liquids was reproduced by computational fluid dynamics simulation. In this study, ethanol was selected as the hazardous...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Akio Horiguchi Satoshi Numazawa Source Type: research
Involvement of microRNA-4680-3p against phenytoin-induced cell proliferation inhibition in human palate cells
J Toxicol Sci. 2024;49(1):1-8. doi: 10.2131/jts.49.1.ABSTRACTCleft palate (CP) is one of the most common birth defects and is caused by a combination of genetic and/or environmental factors. Environmental factors such as pharmaceutical exposure in pregnant women are known to induce CP. Recently, microRNA (miRNA) was found to be affected by environmental factors. The aim of the present study was to investigate the involvement of miRNA against phenytoin (PHE)-induced inhibition of proliferation in human embryonic palatal mesenchymal (HEPM) cells. We demonstrated that PHE inhibited HEPM cell proliferation in a dose-dependent ...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Yosuke Tsukiboshi Hanane Horita Yurie Mikami Azumi Noguchi Satoshi Yokota Kenichi Ogata Hiroki Yoshioka Source Type: research
Industrially produced trans-fatty acids are potent promoters of DNA damage-induced apoptosis
J Toxicol Sci. 2024;49(1):27-36. doi: 10.2131/jts.49.27.ABSTRACTtrans-Fatty acids (TFAs) are unsaturated fatty acids harboring at least one carbon-carbon double bond in trans configuration, which are categorized into two groups according to their origin: industrial and ruminant TFAs, hereafter called iTFAs and rTFAs, respectively. Numerous epidemiological studies have shown a specific link of iTFAs to various diseases, such as cardiovascular and neurodegenerative diseases. However, there is little evidence for underlying mechanisms that can explain the specific toxicity of iTFAs, and how to mitigate their toxicity. Herein,...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Yusuke Hirata Ryota Kojima Ryo Ashida Yuki Nada Shinnosuke Kimura Emiko Sato Takuya Noguchi Atsushi Matsuzawa Source Type: research
Paternal methamphetamine exposure differentially affects first and second generations in mice
J Toxicol Sci. 2024;49(1):9-26. doi: 10.2131/jts.49.9.ABSTRACTAmphetamine-type stimulants are abused worldwide, and methamphetamine (METH) accounts for a large majority of seized abused drug cases. Recently, the paternal origin of health and disease theory has been proposed as a concept wherein paternal factors influence descendants. Although METH abuse is more common among males, its effects on their descendants were not examined. Therefore, we investigated the effects of paternal METH exposure on F1 and F2 levels in a mouse model. Sires were administered METH for 21 days and mated with female mice to obtain F1 mice. Grow...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Sakiko Munetomo-Aoki Asuka Kaizaki-Mitsumoto Ryota Nakano Satoshi Numazawa Source Type: research
Development of a risk assessment method for the detailed consideration of the effects of liquid toxic substance leakage incidents on the human body: ethanol as a model substance
In this study, a risk assessment method was developed for the problem of the leakage of liquid hazardous substances. The risk assessment of toxic liquid leaks must consider the exposure of workers to the liquid and toxic gases produced by vaporization. The absorption and subsequent metabolism of hazardous substances in the body via multiple pathways after exposure to liquids and gases was calculated using a pharmacokinetic model. Estimation of exposure concentrations of toxic gases volatilized from leaked liquids was reproduced by computational fluid dynamics simulation. In this study, ethanol was selected as the hazardous...
Source: Journal of Toxicological Sciences - January 8, 2024 Category: Toxicology Authors: Akio Horiguchi Satoshi Numazawa Source Type: research
Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7
J Toxicol Sci. 2023;48(12):617-639. doi: 10.2131/jts.48.617.ABSTRACTAlthough toxicities of multiwalled carbon nanotube (MWCNT) have been found to be related with activities of macrophages phagocytosing the fibers, the exact relationship between macrophage population and pathogenesis of fibrosis and mesotheliomas induced by MWCNTs is largely unknown. CCL2-CCR2 axis, a major monocyte/macrophage infiltration route, is thought to be involved in not only acute inflammation but also the formation of tumor microenvironment. We therefore described a time-course of alteration of macrophage population in an attempt to clarify the co...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Motomu Shimizu Motoki Hojo Kiyomi Ikushima Yukio Yamamoto Ai Maeno Yoshimitsu Sakamoto Naozumi Ishimaru Yuhji Taquahashi Jun Kanno Akihiko Hirose Jin Suzuki Akiko Inomata Dai Nakae Source Type: research
A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations
We report the case of a 17-year-old man who took 226 tablets of GXR 3 mg for attempted suicide. He was found complaining of dyspnea, and emergency medical services were called. When the patient was transferred to our hospital, his Glasgow coma scale was 12 (E4V3M5). He was agitated and hypoxemic. He was intubated for invasive mechanical ventilation under sedation. His chest X-ray and computed tomography scan showed pulmonary edema. Transthoracic echocardiography showed markedly reduced cardiac function. His serum guanfacine concentration peaked on day 3 after admission. His pulmonary edema improved quickly after a decrease...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Ryo Ayata Motoki Fujita Kayoko Harada Yusuke Esaki Yasutaka Koga Yukari Hisamoto Maki Asami-Noyama Saki Takeda Kazuki Harada Ryosuke Tsuruta Source Type: research
Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study
J Toxicol Sci. 2023;48(12):645-654. doi: 10.2131/jts.48.645.ABSTRACTAntiparasitic ivermectin has been reported to induce cardiovascular adverse events, including orthostatic hypotension, tachycardia and cardiopulmonary arrest, of which the underlying pathophysiology remains unknown. Since its drug repurposing as an antiviral agent is underway at higher doses than those for antiparasitic, we evaluated the cardiovascular safety pharmacology of ivermectin using isoflurane-anesthetized beagle dogs (n=4). Ivermectin in doses of 0.1 followed by 1 mg/kg was intravenously infused over 10 min with an interval of 20 min, attaining p...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Nobuyuki Suzuki Ryuichi Kambayashi Ai Goto Hiroko Izumi-Nakaseko Yoshinori Takei Atsuhiko T Naito Atsushi Sugiyama Source Type: research
Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI < sub > 2 < /sub > pathway in cultured bovine vascular endothelial cells
This study revealed an intracellular pathway-the EGFR-ERK1/2-COX-2-PGI2 pathway activated by inhibition of PTP by lead-as a pathway that downregulates endothelial perlecan synthesis. The pathway is suggested to serve as a mechanism for the repression of perlecan expression, which leads to a delay in cell proliferation by lead.PMID:38044127 | DOI:10.2131/jts.48.655 (Source: Journal of Toxicological Sciences)
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Takato Hara Reina Kumagai Tohru Tanaka Tsuyoshi Nakano Tomoya Fujie Yasuyuki Fujiwara Chika Yamamoto Toshiyuki Kaji Source Type: research
Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7
J Toxicol Sci. 2023;48(12):617-639. doi: 10.2131/jts.48.617.ABSTRACTAlthough toxicities of multiwalled carbon nanotube (MWCNT) have been found to be related with activities of macrophages phagocytosing the fibers, the exact relationship between macrophage population and pathogenesis of fibrosis and mesotheliomas induced by MWCNTs is largely unknown. CCL2-CCR2 axis, a major monocyte/macrophage infiltration route, is thought to be involved in not only acute inflammation but also the formation of tumor microenvironment. We therefore described a time-course of alteration of macrophage population in an attempt to clarify the co...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Motomu Shimizu Motoki Hojo Kiyomi Ikushima Yukio Yamamoto Ai Maeno Yoshimitsu Sakamoto Naozumi Ishimaru Yuhji Taquahashi Jun Kanno Akihiko Hirose Jin Suzuki Akiko Inomata Dai Nakae Source Type: research
A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations
We report the case of a 17-year-old man who took 226 tablets of GXR 3 mg for attempted suicide. He was found complaining of dyspnea, and emergency medical services were called. When the patient was transferred to our hospital, his Glasgow coma scale was 12 (E4V3M5). He was agitated and hypoxemic. He was intubated for invasive mechanical ventilation under sedation. His chest X-ray and computed tomography scan showed pulmonary edema. Transthoracic echocardiography showed markedly reduced cardiac function. His serum guanfacine concentration peaked on day 3 after admission. His pulmonary edema improved quickly after a decrease...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Ryo Ayata Motoki Fujita Kayoko Harada Yusuke Esaki Yasutaka Koga Yukari Hisamoto Maki Asami-Noyama Saki Takeda Kazuki Harada Ryosuke Tsuruta Source Type: research
Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study
J Toxicol Sci. 2023;48(12):645-654. doi: 10.2131/jts.48.645.ABSTRACTAntiparasitic ivermectin has been reported to induce cardiovascular adverse events, including orthostatic hypotension, tachycardia and cardiopulmonary arrest, of which the underlying pathophysiology remains unknown. Since its drug repurposing as an antiviral agent is underway at higher doses than those for antiparasitic, we evaluated the cardiovascular safety pharmacology of ivermectin using isoflurane-anesthetized beagle dogs (n=4). Ivermectin in doses of 0.1 followed by 1 mg/kg was intravenously infused over 10 min with an interval of 20 min, attaining p...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Nobuyuki Suzuki Ryuichi Kambayashi Ai Goto Hiroko Izumi-Nakaseko Yoshinori Takei Atsuhiko T Naito Atsushi Sugiyama Source Type: research
