Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI < sub > 2 < /sub > pathway in cultured bovine vascular endothelial cells
This study revealed an intracellular pathway-the EGFR-ERK1/2-COX-2-PGI2 pathway activated by inhibition of PTP by lead-as a pathway that downregulates endothelial perlecan synthesis. The pathway is suggested to serve as a mechanism for the repression of perlecan expression, which leads to a delay in cell proliferation by lead.PMID:38044127 | DOI:10.2131/jts.48.655 (Source: Journal of Toxicological Sciences)
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Takato Hara Reina Kumagai Tohru Tanaka Tsuyoshi Nakano Tomoya Fujie Yasuyuki Fujiwara Chika Yamamoto Toshiyuki Kaji Source Type: research

Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7
J Toxicol Sci. 2023;48(12):617-639. doi: 10.2131/jts.48.617.ABSTRACTAlthough toxicities of multiwalled carbon nanotube (MWCNT) have been found to be related with activities of macrophages phagocytosing the fibers, the exact relationship between macrophage population and pathogenesis of fibrosis and mesotheliomas induced by MWCNTs is largely unknown. CCL2-CCR2 axis, a major monocyte/macrophage infiltration route, is thought to be involved in not only acute inflammation but also the formation of tumor microenvironment. We therefore described a time-course of alteration of macrophage population in an attempt to clarify the co...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Motomu Shimizu Motoki Hojo Kiyomi Ikushima Yukio Yamamoto Ai Maeno Yoshimitsu Sakamoto Naozumi Ishimaru Yuhji Taquahashi Jun Kanno Akihiko Hirose Jin Suzuki Akiko Inomata Dai Nakae Source Type: research

A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations
We report the case of a 17-year-old man who took 226 tablets of GXR 3 mg for attempted suicide. He was found complaining of dyspnea, and emergency medical services were called. When the patient was transferred to our hospital, his Glasgow coma scale was 12 (E4V3M5). He was agitated and hypoxemic. He was intubated for invasive mechanical ventilation under sedation. His chest X-ray and computed tomography scan showed pulmonary edema. Transthoracic echocardiography showed markedly reduced cardiac function. His serum guanfacine concentration peaked on day 3 after admission. His pulmonary edema improved quickly after a decrease...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Ryo Ayata Motoki Fujita Kayoko Harada Yusuke Esaki Yasutaka Koga Yukari Hisamoto Maki Asami-Noyama Saki Takeda Kazuki Harada Ryosuke Tsuruta Source Type: research

Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study
J Toxicol Sci. 2023;48(12):645-654. doi: 10.2131/jts.48.645.ABSTRACTAntiparasitic ivermectin has been reported to induce cardiovascular adverse events, including orthostatic hypotension, tachycardia and cardiopulmonary arrest, of which the underlying pathophysiology remains unknown. Since its drug repurposing as an antiviral agent is underway at higher doses than those for antiparasitic, we evaluated the cardiovascular safety pharmacology of ivermectin using isoflurane-anesthetized beagle dogs (n=4). Ivermectin in doses of 0.1 followed by 1 mg/kg was intravenously infused over 10 min with an interval of 20 min, attaining p...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Nobuyuki Suzuki Ryuichi Kambayashi Ai Goto Hiroko Izumi-Nakaseko Yoshinori Takei Atsuhiko T Naito Atsushi Sugiyama Source Type: research

Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI < sub > 2 < /sub > pathway in cultured bovine vascular endothelial cells
This study revealed an intracellular pathway-the EGFR-ERK1/2-COX-2-PGI2 pathway activated by inhibition of PTP by lead-as a pathway that downregulates endothelial perlecan synthesis. The pathway is suggested to serve as a mechanism for the repression of perlecan expression, which leads to a delay in cell proliferation by lead.PMID:38044127 | DOI:10.2131/jts.48.655 (Source: Journal of Toxicological Sciences)
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Takato Hara Reina Kumagai Tohru Tanaka Tsuyoshi Nakano Tomoya Fujie Yasuyuki Fujiwara Chika Yamamoto Toshiyuki Kaji Source Type: research

Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7
J Toxicol Sci. 2023;48(12):617-639. doi: 10.2131/jts.48.617.ABSTRACTAlthough toxicities of multiwalled carbon nanotube (MWCNT) have been found to be related with activities of macrophages phagocytosing the fibers, the exact relationship between macrophage population and pathogenesis of fibrosis and mesotheliomas induced by MWCNTs is largely unknown. CCL2-CCR2 axis, a major monocyte/macrophage infiltration route, is thought to be involved in not only acute inflammation but also the formation of tumor microenvironment. We therefore described a time-course of alteration of macrophage population in an attempt to clarify the co...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Motomu Shimizu Motoki Hojo Kiyomi Ikushima Yukio Yamamoto Ai Maeno Yoshimitsu Sakamoto Naozumi Ishimaru Yuhji Taquahashi Jun Kanno Akihiko Hirose Jin Suzuki Akiko Inomata Dai Nakae Source Type: research

A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations
We report the case of a 17-year-old man who took 226 tablets of GXR 3 mg for attempted suicide. He was found complaining of dyspnea, and emergency medical services were called. When the patient was transferred to our hospital, his Glasgow coma scale was 12 (E4V3M5). He was agitated and hypoxemic. He was intubated for invasive mechanical ventilation under sedation. His chest X-ray and computed tomography scan showed pulmonary edema. Transthoracic echocardiography showed markedly reduced cardiac function. His serum guanfacine concentration peaked on day 3 after admission. His pulmonary edema improved quickly after a decrease...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Ryo Ayata Motoki Fujita Kayoko Harada Yusuke Esaki Yasutaka Koga Yukari Hisamoto Maki Asami-Noyama Saki Takeda Kazuki Harada Ryosuke Tsuruta Source Type: research

Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study
J Toxicol Sci. 2023;48(12):645-654. doi: 10.2131/jts.48.645.ABSTRACTAntiparasitic ivermectin has been reported to induce cardiovascular adverse events, including orthostatic hypotension, tachycardia and cardiopulmonary arrest, of which the underlying pathophysiology remains unknown. Since its drug repurposing as an antiviral agent is underway at higher doses than those for antiparasitic, we evaluated the cardiovascular safety pharmacology of ivermectin using isoflurane-anesthetized beagle dogs (n=4). Ivermectin in doses of 0.1 followed by 1 mg/kg was intravenously infused over 10 min with an interval of 20 min, attaining p...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Nobuyuki Suzuki Ryuichi Kambayashi Ai Goto Hiroko Izumi-Nakaseko Yoshinori Takei Atsuhiko T Naito Atsushi Sugiyama Source Type: research

Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI < sub > 2 < /sub > pathway in cultured bovine vascular endothelial cells
This study revealed an intracellular pathway-the EGFR-ERK1/2-COX-2-PGI2 pathway activated by inhibition of PTP by lead-as a pathway that downregulates endothelial perlecan synthesis. The pathway is suggested to serve as a mechanism for the repression of perlecan expression, which leads to a delay in cell proliferation by lead.PMID:38044127 | DOI:10.2131/jts.48.655 (Source: Journal of Toxicological Sciences)
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Takato Hara Reina Kumagai Tohru Tanaka Tsuyoshi Nakano Tomoya Fujie Yasuyuki Fujiwara Chika Yamamoto Toshiyuki Kaji Source Type: research

Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7
J Toxicol Sci. 2023;48(12):617-639. doi: 10.2131/jts.48.617.ABSTRACTAlthough toxicities of multiwalled carbon nanotube (MWCNT) have been found to be related with activities of macrophages phagocytosing the fibers, the exact relationship between macrophage population and pathogenesis of fibrosis and mesotheliomas induced by MWCNTs is largely unknown. CCL2-CCR2 axis, a major monocyte/macrophage infiltration route, is thought to be involved in not only acute inflammation but also the formation of tumor microenvironment. We therefore described a time-course of alteration of macrophage population in an attempt to clarify the co...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Motomu Shimizu Motoki Hojo Kiyomi Ikushima Yukio Yamamoto Ai Maeno Yoshimitsu Sakamoto Naozumi Ishimaru Yuhji Taquahashi Jun Kanno Akihiko Hirose Jin Suzuki Akiko Inomata Dai Nakae Source Type: research

A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations
We report the case of a 17-year-old man who took 226 tablets of GXR 3 mg for attempted suicide. He was found complaining of dyspnea, and emergency medical services were called. When the patient was transferred to our hospital, his Glasgow coma scale was 12 (E4V3M5). He was agitated and hypoxemic. He was intubated for invasive mechanical ventilation under sedation. His chest X-ray and computed tomography scan showed pulmonary edema. Transthoracic echocardiography showed markedly reduced cardiac function. His serum guanfacine concentration peaked on day 3 after admission. His pulmonary edema improved quickly after a decrease...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Ryo Ayata Motoki Fujita Kayoko Harada Yusuke Esaki Yasutaka Koga Yukari Hisamoto Maki Asami-Noyama Saki Takeda Kazuki Harada Ryosuke Tsuruta Source Type: research

Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study
J Toxicol Sci. 2023;48(12):645-654. doi: 10.2131/jts.48.645.ABSTRACTAntiparasitic ivermectin has been reported to induce cardiovascular adverse events, including orthostatic hypotension, tachycardia and cardiopulmonary arrest, of which the underlying pathophysiology remains unknown. Since its drug repurposing as an antiviral agent is underway at higher doses than those for antiparasitic, we evaluated the cardiovascular safety pharmacology of ivermectin using isoflurane-anesthetized beagle dogs (n=4). Ivermectin in doses of 0.1 followed by 1 mg/kg was intravenously infused over 10 min with an interval of 20 min, attaining p...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Nobuyuki Suzuki Ryuichi Kambayashi Ai Goto Hiroko Izumi-Nakaseko Yoshinori Takei Atsuhiko T Naito Atsushi Sugiyama Source Type: research

Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI < sub > 2 < /sub > pathway in cultured bovine vascular endothelial cells
This study revealed an intracellular pathway-the EGFR-ERK1/2-COX-2-PGI2 pathway activated by inhibition of PTP by lead-as a pathway that downregulates endothelial perlecan synthesis. The pathway is suggested to serve as a mechanism for the repression of perlecan expression, which leads to a delay in cell proliferation by lead.PMID:38044127 | DOI:10.2131/jts.48.655 (Source: Journal of Toxicological Sciences)
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Takato Hara Reina Kumagai Tohru Tanaka Tsuyoshi Nakano Tomoya Fujie Yasuyuki Fujiwara Chika Yamamoto Toshiyuki Kaji Source Type: research

Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7
J Toxicol Sci. 2023;48(12):617-639. doi: 10.2131/jts.48.617.ABSTRACTAlthough toxicities of multiwalled carbon nanotube (MWCNT) have been found to be related with activities of macrophages phagocytosing the fibers, the exact relationship between macrophage population and pathogenesis of fibrosis and mesotheliomas induced by MWCNTs is largely unknown. CCL2-CCR2 axis, a major monocyte/macrophage infiltration route, is thought to be involved in not only acute inflammation but also the formation of tumor microenvironment. We therefore described a time-course of alteration of macrophage population in an attempt to clarify the co...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Motomu Shimizu Motoki Hojo Kiyomi Ikushima Yukio Yamamoto Ai Maeno Yoshimitsu Sakamoto Naozumi Ishimaru Yuhji Taquahashi Jun Kanno Akihiko Hirose Jin Suzuki Akiko Inomata Dai Nakae Source Type: research

A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations
We report the case of a 17-year-old man who took 226 tablets of GXR 3 mg for attempted suicide. He was found complaining of dyspnea, and emergency medical services were called. When the patient was transferred to our hospital, his Glasgow coma scale was 12 (E4V3M5). He was agitated and hypoxemic. He was intubated for invasive mechanical ventilation under sedation. His chest X-ray and computed tomography scan showed pulmonary edema. Transthoracic echocardiography showed markedly reduced cardiac function. His serum guanfacine concentration peaked on day 3 after admission. His pulmonary edema improved quickly after a decrease...
Source: Journal of Toxicological Sciences - December 3, 2023 Category: Toxicology Authors: Ryo Ayata Motoki Fujita Kayoko Harada Yusuke Esaki Yasutaka Koga Yukari Hisamoto Maki Asami-Noyama Saki Takeda Kazuki Harada Ryosuke Tsuruta Source Type: research