Spontaneous mandibular follicular ameloblastoma in a female Sprague-Dawley rat
J Toxicol Pathol. 2024 Jan;37(1):39-43. doi: 10.1293/tox.2023-0072. Epub 2023 Nov 13.ABSTRACTAmeloblastoma is a locally aggressive tumor derived from the odontogenic epithelium of the developing tooth germ. It is rarely reported in experimental Sprague-Dawley (SD) rats. In this 90-day percutaneous repeated-dose toxicity study, mandibular nodules were observed from day 56 to 90. Upon necropsy, a well-demarcated nodule, approximately 1.2×1.0×1.0 cm, was found attached to the mandibular bone, alongside the unerupted left incisor. Histopathologically, the epithelial cells formed islands, nests, or anastomosing strands. The e...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Juan Li Guojian Jiang Jie Zhang Zhuolin Ou Xin Wu Yueshu Liu Source Type: research
Molecular autopsy for sudden death in Japan
J Toxicol Pathol. 2024 Jan;37(1):1-10. doi: 10.1293/tox.2023-0080. Epub 2023 Aug 30.ABSTRACTJapan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal morphological abnormalities, whereas the cause of death in cases with non-morphological abnormalities can be detected through additional examinations. Molecular autopsy and postmortem genetic analyses are important additional examinations. They are capable of detecting inherited arrhythmias or in...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Takuma Yamamoto Yuko Emoto Takehiko Murase Takahiro Umehara Aya Miura Minori Nishiguchi Kazuya Ikematsu Hajime Nishio Source Type: research
Lobular distribution of enhanced expression levels of heat shock proteins using < em > in-situ < /em > hybridization in the mouse liver treated with a single administration of CCl4
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c mice given a single oral administration of CCl4 were euthanized 6 hours or 1 day after the administration (6 h or 1 day). Paraffin-embedded liver samples were obtained, ISH for HSPs was conducted, as well as hematoxylin-eosin staining and immunohistochemistry (IHC). At 6 h, centrilobular hepatocellular vacuolization was observed, and increased signals for Hspa1a, Hspa1b, and Grp78, which ...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Hitoshi Kandori Masami Aoki Yumiko Miyamoto Sayuri Nakamura Ryosuke Kobayashi Mitsuharu Matsumoto Kotaro Yokoyama Source Type: research
Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway
J Toxicol Pathol. 2024 Jan;37(1):11-27. doi: 10.1293/tox.2023-0098. Epub 2023 Nov 1.ABSTRACTThe pathogenesis of nasal cavity tumors induced in rodents has been critically reviewed. Chemical substances that induce nasal cavity tumors in rats, mice, and hamsters were searched in the National Toxicology Program (NTP), International Agency for Research on Cancer (IARC), and Japan Bioassay Research Center (JBRC) databases, in addition to PubMed. Detailed data such as animal species, administration routes, and histopathological types were extracted for induced nasal cavity tumors. Data on non-neoplastic lesions were also extract...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Akiyoshi Nishikawa Kasuke Nagano Hajime Kojima Shoji Fukushima Kumiko Ogawa Source Type: research
Spontaneous mandibular follicular ameloblastoma in a female Sprague-Dawley rat
J Toxicol Pathol. 2024 Jan;37(1):39-43. doi: 10.1293/tox.2023-0072. Epub 2023 Nov 13.ABSTRACTAmeloblastoma is a locally aggressive tumor derived from the odontogenic epithelium of the developing tooth germ. It is rarely reported in experimental Sprague-Dawley (SD) rats. In this 90-day percutaneous repeated-dose toxicity study, mandibular nodules were observed from day 56 to 90. Upon necropsy, a well-demarcated nodule, approximately 1.2×1.0×1.0 cm, was found attached to the mandibular bone, alongside the unerupted left incisor. Histopathologically, the epithelial cells formed islands, nests, or anastomosing strands. The e...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Juan Li Guojian Jiang Jie Zhang Zhuolin Ou Xin Wu Yueshu Liu Source Type: research
Molecular autopsy for sudden death in Japan
J Toxicol Pathol. 2024 Jan;37(1):1-10. doi: 10.1293/tox.2023-0080. Epub 2023 Aug 30.ABSTRACTJapan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal morphological abnormalities, whereas the cause of death in cases with non-morphological abnormalities can be detected through additional examinations. Molecular autopsy and postmortem genetic analyses are important additional examinations. They are capable of detecting inherited arrhythmias or in...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Takuma Yamamoto Yuko Emoto Takehiko Murase Takahiro Umehara Aya Miura Minori Nishiguchi Kazuya Ikematsu Hajime Nishio Source Type: research
Lobular distribution of enhanced expression levels of heat shock proteins using < em > in-situ < /em > hybridization in the mouse liver treated with a single administration of CCl4
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c mice given a single oral administration of CCl4 were euthanized 6 hours or 1 day after the administration (6 h or 1 day). Paraffin-embedded liver samples were obtained, ISH for HSPs was conducted, as well as hematoxylin-eosin staining and immunohistochemistry (IHC). At 6 h, centrilobular hepatocellular vacuolization was observed, and increased signals for Hspa1a, Hspa1b, and Grp78, which ...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Hitoshi Kandori Masami Aoki Yumiko Miyamoto Sayuri Nakamura Ryosuke Kobayashi Mitsuharu Matsumoto Kotaro Yokoyama Source Type: research
Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway
J Toxicol Pathol. 2024 Jan;37(1):11-27. doi: 10.1293/tox.2023-0098. Epub 2023 Nov 1.ABSTRACTThe pathogenesis of nasal cavity tumors induced in rodents has been critically reviewed. Chemical substances that induce nasal cavity tumors in rats, mice, and hamsters were searched in the National Toxicology Program (NTP), International Agency for Research on Cancer (IARC), and Japan Bioassay Research Center (JBRC) databases, in addition to PubMed. Detailed data such as animal species, administration routes, and histopathological types were extracted for induced nasal cavity tumors. Data on non-neoplastic lesions were also extract...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Akiyoshi Nishikawa Kasuke Nagano Hajime Kojima Shoji Fukushima Kumiko Ogawa Source Type: research
Spontaneous mandibular follicular ameloblastoma in a female Sprague-Dawley rat
J Toxicol Pathol. 2024 Jan;37(1):39-43. doi: 10.1293/tox.2023-0072. Epub 2023 Nov 13.ABSTRACTAmeloblastoma is a locally aggressive tumor derived from the odontogenic epithelium of the developing tooth germ. It is rarely reported in experimental Sprague-Dawley (SD) rats. In this 90-day percutaneous repeated-dose toxicity study, mandibular nodules were observed from day 56 to 90. Upon necropsy, a well-demarcated nodule, approximately 1.2×1.0×1.0 cm, was found attached to the mandibular bone, alongside the unerupted left incisor. Histopathologically, the epithelial cells formed islands, nests, or anastomosing strands. The e...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Juan Li Guojian Jiang Jie Zhang Zhuolin Ou Xin Wu Yueshu Liu Source Type: research
Molecular autopsy for sudden death in Japan
J Toxicol Pathol. 2024 Jan;37(1):1-10. doi: 10.1293/tox.2023-0080. Epub 2023 Aug 30.ABSTRACTJapan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal morphological abnormalities, whereas the cause of death in cases with non-morphological abnormalities can be detected through additional examinations. Molecular autopsy and postmortem genetic analyses are important additional examinations. They are capable of detecting inherited arrhythmias or in...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Takuma Yamamoto Yuko Emoto Takehiko Murase Takahiro Umehara Aya Miura Minori Nishiguchi Kazuya Ikematsu Hajime Nishio Source Type: research
Lobular distribution of enhanced expression levels of heat shock proteins using < em > in-situ < /em > hybridization in the mouse liver treated with a single administration of CCl4
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c mice given a single oral administration of CCl4 were euthanized 6 hours or 1 day after the administration (6 h or 1 day). Paraffin-embedded liver samples were obtained, ISH for HSPs was conducted, as well as hematoxylin-eosin staining and immunohistochemistry (IHC). At 6 h, centrilobular hepatocellular vacuolization was observed, and increased signals for Hspa1a, Hspa1b, and Grp78, which ...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Hitoshi Kandori Masami Aoki Yumiko Miyamoto Sayuri Nakamura Ryosuke Kobayashi Mitsuharu Matsumoto Kotaro Yokoyama Source Type: research
Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway
J Toxicol Pathol. 2024 Jan;37(1):11-27. doi: 10.1293/tox.2023-0098. Epub 2023 Nov 1.ABSTRACTThe pathogenesis of nasal cavity tumors induced in rodents has been critically reviewed. Chemical substances that induce nasal cavity tumors in rats, mice, and hamsters were searched in the National Toxicology Program (NTP), International Agency for Research on Cancer (IARC), and Japan Bioassay Research Center (JBRC) databases, in addition to PubMed. Detailed data such as animal species, administration routes, and histopathological types were extracted for induced nasal cavity tumors. Data on non-neoplastic lesions were also extract...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Akiyoshi Nishikawa Kasuke Nagano Hajime Kojima Shoji Fukushima Kumiko Ogawa Source Type: research
Spontaneous mandibular follicular ameloblastoma in a female Sprague-Dawley rat
J Toxicol Pathol. 2024 Jan;37(1):39-43. doi: 10.1293/tox.2023-0072. Epub 2023 Nov 13.ABSTRACTAmeloblastoma is a locally aggressive tumor derived from the odontogenic epithelium of the developing tooth germ. It is rarely reported in experimental Sprague-Dawley (SD) rats. In this 90-day percutaneous repeated-dose toxicity study, mandibular nodules were observed from day 56 to 90. Upon necropsy, a well-demarcated nodule, approximately 1.2×1.0×1.0 cm, was found attached to the mandibular bone, alongside the unerupted left incisor. Histopathologically, the epithelial cells formed islands, nests, or anastomosing strands. The e...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Juan Li Guojian Jiang Jie Zhang Zhuolin Ou Xin Wu Yueshu Liu Source Type: research
Molecular autopsy for sudden death in Japan
J Toxicol Pathol. 2024 Jan;37(1):1-10. doi: 10.1293/tox.2023-0080. Epub 2023 Aug 30.ABSTRACTJapan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal morphological abnormalities, whereas the cause of death in cases with non-morphological abnormalities can be detected through additional examinations. Molecular autopsy and postmortem genetic analyses are important additional examinations. They are capable of detecting inherited arrhythmias or in...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Takuma Yamamoto Yuko Emoto Takehiko Murase Takahiro Umehara Aya Miura Minori Nishiguchi Kazuya Ikematsu Hajime Nishio Source Type: research
Lobular distribution of enhanced expression levels of heat shock proteins using < em > in-situ < /em > hybridization in the mouse liver treated with a single administration of CCl4
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c mice given a single oral administration of CCl4 were euthanized 6 hours or 1 day after the administration (6 h or 1 day). Paraffin-embedded liver samples were obtained, ISH for HSPs was conducted, as well as hematoxylin-eosin staining and immunohistochemistry (IHC). At 6 h, centrilobular hepatocellular vacuolization was observed, and increased signals for Hspa1a, Hspa1b, and Grp78, which ...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Hitoshi Kandori Masami Aoki Yumiko Miyamoto Sayuri Nakamura Ryosuke Kobayashi Mitsuharu Matsumoto Kotaro Yokoyama Source Type: research
