Smooth muscle hamartoma of the lungs in a Wistar Hannover rat
J Toxicol Pathol. 2023 Oct;36(4):193-198. doi: 10.1293/tox.2023-0056. Epub 2023 Jul 7.ABSTRACTHamartomas are tumor-like masses comprising disorganized normal tissue elements. To date, spontaneous hamartomas have been reported in several organs and tissues in rodents but not in the lungs. Here, we report the first case of a hamartoma in the lungs of a 108-week-old female Wistar Hannover rat. Grossly, a white spot, 7 mm in diameter, was observed on the costal surface of the left lung. Histopathologically, the nodular lesions adjacent to the bronchioles comprised mature smooth muscle cells. The lesion was not encapsulated and...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shinya Miyazaki Chinatsu Fujiwara Yoshitaka Katoh Tsuyoshi Ito Aya Koyama Naofumi Takahashi Atsushi Shiga Takanori Harada Source Type: research
Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson's disease monkey model
J Toxicol Pathol. 2023 Oct;36(4):199-204. doi: 10.1293/tox.2023-0010. Epub 2023 May 24.ABSTRACTDetermining the optimal timing for histopathological examination following exposure to a test article is crucial for assessing neurotoxicity. However, no study has focused on identifying an ideal dataset to define the optimal timing for histopathological examination of central nervous system (CNS) toxicity in monkeys. Therefore, this study aimed to define a predictive endpoint that would guide us in selecting the optimal timing for histopathological examination of CNS toxicity in monkeys. Four cynomolgus monkeys were administered...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Hironobu Yasuno Yasushi Masuda Harushige Ozaki Tomoya Sano Tadahiro Shinozawa Takeshi Watanabe Source Type: research
Pathological analysis of lesions in the exocrine pancreas of rats induced by Zinc Maltol
In conclusion, we provided a detailed description of ZM-induced pancreatic lesions in SD rats.PMID:37868114 | PMC:PMC10585244 | DOI:10.1293/tox.2023-0063 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Sakura Fujiwara Takayasu Moroki Masaya Hitomi Makoto Sato Yui Terayama Tsuyoshi Yoshikawa Source Type: research
Histopathology of fused triplet placenta in rat
J Toxicol Pathol. 2023 Oct;36(4):187-192. doi: 10.1293/tox.2023-0026. Epub 2023 Jun 5.ABSTRACTA fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each placenta (referred to as PL-A, PL-B, and PL-C) of this fused placenta was attached to one fetus each, but their fetal weights were lower than that of the fetus attached to the only normal placenta (referred to as PL-N) in this dam. Histopathologically, thinning of the trophoblastic septa and dilatation of the maternal sinusoid in the labyrinth zone were observed in PL-B and PL-C, but not in PL-A or PL-N. The points of placental fusion were at ...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Satoshi Furukawa Naho Tsuji Seigo Hayashi Yusuke Kuroda Masayuki Kimura Chisato Kojima Kazuya Takeuchi Source Type: research
Retraction: Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed < em > In Utero < /em > to Di( < em > n < /em > -butyl) Phthalate
J Toxicol Pathol. 2023 Oct;36(4):212. doi: 10.1293/tox.36.R1. Epub 2023 Oct 6.ABSTRACT[This retracts the article on p. 439 in vol. 26, PMID: 24526819.].PMID:37868116 | PMC:PMC10585245 | DOI:10.1293/tox.36.R1 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shin Wakui Masaya Motohashi Takemi Satoh Masaru Shirai Tomoko Mutou Hiroyuki Takahashi Michael F Wempe Hitoshi Endou Tomoo Inomata Masao Asari Source Type: research
Smooth muscle hamartoma of the lungs in a Wistar Hannover rat
J Toxicol Pathol. 2023 Oct;36(4):193-198. doi: 10.1293/tox.2023-0056. Epub 2023 Jul 7.ABSTRACTHamartomas are tumor-like masses comprising disorganized normal tissue elements. To date, spontaneous hamartomas have been reported in several organs and tissues in rodents but not in the lungs. Here, we report the first case of a hamartoma in the lungs of a 108-week-old female Wistar Hannover rat. Grossly, a white spot, 7 mm in diameter, was observed on the costal surface of the left lung. Histopathologically, the nodular lesions adjacent to the bronchioles comprised mature smooth muscle cells. The lesion was not encapsulated and...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shinya Miyazaki Chinatsu Fujiwara Yoshitaka Katoh Tsuyoshi Ito Aya Koyama Naofumi Takahashi Atsushi Shiga Takanori Harada Source Type: research
Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson's disease monkey model
J Toxicol Pathol. 2023 Oct;36(4):199-204. doi: 10.1293/tox.2023-0010. Epub 2023 May 24.ABSTRACTDetermining the optimal timing for histopathological examination following exposure to a test article is crucial for assessing neurotoxicity. However, no study has focused on identifying an ideal dataset to define the optimal timing for histopathological examination of central nervous system (CNS) toxicity in monkeys. Therefore, this study aimed to define a predictive endpoint that would guide us in selecting the optimal timing for histopathological examination of CNS toxicity in monkeys. Four cynomolgus monkeys were administered...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Hironobu Yasuno Yasushi Masuda Harushige Ozaki Tomoya Sano Tadahiro Shinozawa Takeshi Watanabe Source Type: research
Pathological analysis of lesions in the exocrine pancreas of rats induced by Zinc Maltol
In conclusion, we provided a detailed description of ZM-induced pancreatic lesions in SD rats.PMID:37868114 | PMC:PMC10585244 | DOI:10.1293/tox.2023-0063 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Sakura Fujiwara Takayasu Moroki Masaya Hitomi Makoto Sato Yui Terayama Tsuyoshi Yoshikawa Source Type: research
Histopathology of fused triplet placenta in rat
J Toxicol Pathol. 2023 Oct;36(4):187-192. doi: 10.1293/tox.2023-0026. Epub 2023 Jun 5.ABSTRACTA fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each placenta (referred to as PL-A, PL-B, and PL-C) of this fused placenta was attached to one fetus each, but their fetal weights were lower than that of the fetus attached to the only normal placenta (referred to as PL-N) in this dam. Histopathologically, thinning of the trophoblastic septa and dilatation of the maternal sinusoid in the labyrinth zone were observed in PL-B and PL-C, but not in PL-A or PL-N. The points of placental fusion were at ...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Satoshi Furukawa Naho Tsuji Seigo Hayashi Yusuke Kuroda Masayuki Kimura Chisato Kojima Kazuya Takeuchi Source Type: research
Retraction: Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed < em > In Utero < /em > to Di( < em > n < /em > -butyl) Phthalate
J Toxicol Pathol. 2023 Oct;36(4):212. doi: 10.1293/tox.36.R1. Epub 2023 Oct 6.ABSTRACT[This retracts the article on p. 439 in vol. 26, PMID: 24526819.].PMID:37868116 | PMC:PMC10585245 | DOI:10.1293/tox.36.R1 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shin Wakui Masaya Motohashi Takemi Satoh Masaru Shirai Tomoko Mutou Hiroyuki Takahashi Michael F Wempe Hitoshi Endou Tomoo Inomata Masao Asari Source Type: research
Smooth muscle hamartoma of the lungs in a Wistar Hannover rat
J Toxicol Pathol. 2023 Oct;36(4):193-198. doi: 10.1293/tox.2023-0056. Epub 2023 Jul 7.ABSTRACTHamartomas are tumor-like masses comprising disorganized normal tissue elements. To date, spontaneous hamartomas have been reported in several organs and tissues in rodents but not in the lungs. Here, we report the first case of a hamartoma in the lungs of a 108-week-old female Wistar Hannover rat. Grossly, a white spot, 7 mm in diameter, was observed on the costal surface of the left lung. Histopathologically, the nodular lesions adjacent to the bronchioles comprised mature smooth muscle cells. The lesion was not encapsulated and...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shinya Miyazaki Chinatsu Fujiwara Yoshitaka Katoh Tsuyoshi Ito Aya Koyama Naofumi Takahashi Atsushi Shiga Takanori Harada Source Type: research
Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson's disease monkey model
J Toxicol Pathol. 2023 Oct;36(4):199-204. doi: 10.1293/tox.2023-0010. Epub 2023 May 24.ABSTRACTDetermining the optimal timing for histopathological examination following exposure to a test article is crucial for assessing neurotoxicity. However, no study has focused on identifying an ideal dataset to define the optimal timing for histopathological examination of central nervous system (CNS) toxicity in monkeys. Therefore, this study aimed to define a predictive endpoint that would guide us in selecting the optimal timing for histopathological examination of CNS toxicity in monkeys. Four cynomolgus monkeys were administered...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Hironobu Yasuno Yasushi Masuda Harushige Ozaki Tomoya Sano Tadahiro Shinozawa Takeshi Watanabe Source Type: research
Pathological analysis of lesions in the exocrine pancreas of rats induced by Zinc Maltol
In conclusion, we provided a detailed description of ZM-induced pancreatic lesions in SD rats.PMID:37868114 | PMC:PMC10585244 | DOI:10.1293/tox.2023-0063 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Sakura Fujiwara Takayasu Moroki Masaya Hitomi Makoto Sato Yui Terayama Tsuyoshi Yoshikawa Source Type: research
Histopathology of fused triplet placenta in rat
J Toxicol Pathol. 2023 Oct;36(4):187-192. doi: 10.1293/tox.2023-0026. Epub 2023 Jun 5.ABSTRACTA fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each placenta (referred to as PL-A, PL-B, and PL-C) of this fused placenta was attached to one fetus each, but their fetal weights were lower than that of the fetus attached to the only normal placenta (referred to as PL-N) in this dam. Histopathologically, thinning of the trophoblastic septa and dilatation of the maternal sinusoid in the labyrinth zone were observed in PL-B and PL-C, but not in PL-A or PL-N. The points of placental fusion were at ...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Satoshi Furukawa Naho Tsuji Seigo Hayashi Yusuke Kuroda Masayuki Kimura Chisato Kojima Kazuya Takeuchi Source Type: research
Retraction: Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed < em > In Utero < /em > to Di( < em > n < /em > -butyl) Phthalate
J Toxicol Pathol. 2023 Oct;36(4):212. doi: 10.1293/tox.36.R1. Epub 2023 Oct 6.ABSTRACT[This retracts the article on p. 439 in vol. 26, PMID: 24526819.].PMID:37868116 | PMC:PMC10585245 | DOI:10.1293/tox.36.R1 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shin Wakui Masaya Motohashi Takemi Satoh Masaru Shirai Tomoko Mutou Hiroyuki Takahashi Michael F Wempe Hitoshi Endou Tomoo Inomata Masao Asari Source Type: research
