Spontaneous mandibular follicular ameloblastoma in a female Sprague-Dawley rat
J Toxicol Pathol. 2024 Jan;37(1):39-43. doi: 10.1293/tox.2023-0072. Epub 2023 Nov 13.ABSTRACTAmeloblastoma is a locally aggressive tumor derived from the odontogenic epithelium of the developing tooth germ. It is rarely reported in experimental Sprague-Dawley (SD) rats. In this 90-day percutaneous repeated-dose toxicity study, mandibular nodules were observed from day 56 to 90. Upon necropsy, a well-demarcated nodule, approximately 1.2×1.0×1.0 cm, was found attached to the mandibular bone, alongside the unerupted left incisor. Histopathologically, the epithelial cells formed islands, nests, or anastomosing strands. The e...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Juan Li Guojian Jiang Jie Zhang Zhuolin Ou Xin Wu Yueshu Liu Source Type: research
Molecular autopsy for sudden death in Japan
J Toxicol Pathol. 2024 Jan;37(1):1-10. doi: 10.1293/tox.2023-0080. Epub 2023 Aug 30.ABSTRACTJapan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal morphological abnormalities, whereas the cause of death in cases with non-morphological abnormalities can be detected through additional examinations. Molecular autopsy and postmortem genetic analyses are important additional examinations. They are capable of detecting inherited arrhythmias or in...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Takuma Yamamoto Yuko Emoto Takehiko Murase Takahiro Umehara Aya Miura Minori Nishiguchi Kazuya Ikematsu Hajime Nishio Source Type: research
Lobular distribution of enhanced expression levels of heat shock proteins using < em > in-situ < /em > hybridization in the mouse liver treated with a single administration of CCl4
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c mice given a single oral administration of CCl4 were euthanized 6 hours or 1 day after the administration (6 h or 1 day). Paraffin-embedded liver samples were obtained, ISH for HSPs was conducted, as well as hematoxylin-eosin staining and immunohistochemistry (IHC). At 6 h, centrilobular hepatocellular vacuolization was observed, and increased signals for Hspa1a, Hspa1b, and Grp78, which ...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Hitoshi Kandori Masami Aoki Yumiko Miyamoto Sayuri Nakamura Ryosuke Kobayashi Mitsuharu Matsumoto Kotaro Yokoyama Source Type: research
Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway
J Toxicol Pathol. 2024 Jan;37(1):11-27. doi: 10.1293/tox.2023-0098. Epub 2023 Nov 1.ABSTRACTThe pathogenesis of nasal cavity tumors induced in rodents has been critically reviewed. Chemical substances that induce nasal cavity tumors in rats, mice, and hamsters were searched in the National Toxicology Program (NTP), International Agency for Research on Cancer (IARC), and Japan Bioassay Research Center (JBRC) databases, in addition to PubMed. Detailed data such as animal species, administration routes, and histopathological types were extracted for induced nasal cavity tumors. Data on non-neoplastic lesions were also extract...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Akiyoshi Nishikawa Kasuke Nagano Hajime Kojima Shoji Fukushima Kumiko Ogawa Source Type: research
Spontaneous mandibular follicular ameloblastoma in a female Sprague-Dawley rat
J Toxicol Pathol. 2024 Jan;37(1):39-43. doi: 10.1293/tox.2023-0072. Epub 2023 Nov 13.ABSTRACTAmeloblastoma is a locally aggressive tumor derived from the odontogenic epithelium of the developing tooth germ. It is rarely reported in experimental Sprague-Dawley (SD) rats. In this 90-day percutaneous repeated-dose toxicity study, mandibular nodules were observed from day 56 to 90. Upon necropsy, a well-demarcated nodule, approximately 1.2×1.0×1.0 cm, was found attached to the mandibular bone, alongside the unerupted left incisor. Histopathologically, the epithelial cells formed islands, nests, or anastomosing strands. The e...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Juan Li Guojian Jiang Jie Zhang Zhuolin Ou Xin Wu Yueshu Liu Source Type: research
Molecular autopsy for sudden death in Japan
J Toxicol Pathol. 2024 Jan;37(1):1-10. doi: 10.1293/tox.2023-0080. Epub 2023 Aug 30.ABSTRACTJapan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal morphological abnormalities, whereas the cause of death in cases with non-morphological abnormalities can be detected through additional examinations. Molecular autopsy and postmortem genetic analyses are important additional examinations. They are capable of detecting inherited arrhythmias or in...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Takuma Yamamoto Yuko Emoto Takehiko Murase Takahiro Umehara Aya Miura Minori Nishiguchi Kazuya Ikematsu Hajime Nishio Source Type: research
Lobular distribution of enhanced expression levels of heat shock proteins using < em > in-situ < /em > hybridization in the mouse liver treated with a single administration of CCl4
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c mice given a single oral administration of CCl4 were euthanized 6 hours or 1 day after the administration (6 h or 1 day). Paraffin-embedded liver samples were obtained, ISH for HSPs was conducted, as well as hematoxylin-eosin staining and immunohistochemistry (IHC). At 6 h, centrilobular hepatocellular vacuolization was observed, and increased signals for Hspa1a, Hspa1b, and Grp78, which ...
Source: Journal of Toxicologic Pathology - January 29, 2024 Category: Toxicology Authors: Hitoshi Kandori Masami Aoki Yumiko Miyamoto Sayuri Nakamura Ryosuke Kobayashi Mitsuharu Matsumoto Kotaro Yokoyama Source Type: research
Pathological analysis of lesions in the exocrine pancreas of rats induced by Zinc Maltol
In conclusion, we provided a detailed description of ZM-induced pancreatic lesions in SD rats.PMID:37868114 | PMC:PMC10585244 | DOI:10.1293/tox.2023-0063 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Sakura Fujiwara Takayasu Moroki Masaya Hitomi Makoto Sato Yui Terayama Tsuyoshi Yoshikawa Source Type: research
Histopathology of fused triplet placenta in rat
J Toxicol Pathol. 2023 Oct;36(4):187-192. doi: 10.1293/tox.2023-0026. Epub 2023 Jun 5.ABSTRACTA fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each placenta (referred to as PL-A, PL-B, and PL-C) of this fused placenta was attached to one fetus each, but their fetal weights were lower than that of the fetus attached to the only normal placenta (referred to as PL-N) in this dam. Histopathologically, thinning of the trophoblastic septa and dilatation of the maternal sinusoid in the labyrinth zone were observed in PL-B and PL-C, but not in PL-A or PL-N. The points of placental fusion were at ...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Satoshi Furukawa Naho Tsuji Seigo Hayashi Yusuke Kuroda Masayuki Kimura Chisato Kojima Kazuya Takeuchi Source Type: research
Retraction: Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed < em > In Utero < /em > to Di( < em > n < /em > -butyl) Phthalate
J Toxicol Pathol. 2023 Oct;36(4):212. doi: 10.1293/tox.36.R1. Epub 2023 Oct 6.ABSTRACT[This retracts the article on p. 439 in vol. 26, PMID: 24526819.].PMID:37868116 | PMC:PMC10585245 | DOI:10.1293/tox.36.R1 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shin Wakui Masaya Motohashi Takemi Satoh Masaru Shirai Tomoko Mutou Hiroyuki Takahashi Michael F Wempe Hitoshi Endou Tomoo Inomata Masao Asari Source Type: research
Smooth muscle hamartoma of the lungs in a Wistar Hannover rat
J Toxicol Pathol. 2023 Oct;36(4):193-198. doi: 10.1293/tox.2023-0056. Epub 2023 Jul 7.ABSTRACTHamartomas are tumor-like masses comprising disorganized normal tissue elements. To date, spontaneous hamartomas have been reported in several organs and tissues in rodents but not in the lungs. Here, we report the first case of a hamartoma in the lungs of a 108-week-old female Wistar Hannover rat. Grossly, a white spot, 7 mm in diameter, was observed on the costal surface of the left lung. Histopathologically, the nodular lesions adjacent to the bronchioles comprised mature smooth muscle cells. The lesion was not encapsulated and...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shinya Miyazaki Chinatsu Fujiwara Yoshitaka Katoh Tsuyoshi Ito Aya Koyama Naofumi Takahashi Atsushi Shiga Takanori Harada Source Type: research
Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson's disease monkey model
J Toxicol Pathol. 2023 Oct;36(4):199-204. doi: 10.1293/tox.2023-0010. Epub 2023 May 24.ABSTRACTDetermining the optimal timing for histopathological examination following exposure to a test article is crucial for assessing neurotoxicity. However, no study has focused on identifying an ideal dataset to define the optimal timing for histopathological examination of central nervous system (CNS) toxicity in monkeys. Therefore, this study aimed to define a predictive endpoint that would guide us in selecting the optimal timing for histopathological examination of CNS toxicity in monkeys. Four cynomolgus monkeys were administered...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Hironobu Yasuno Yasushi Masuda Harushige Ozaki Tomoya Sano Tadahiro Shinozawa Takeshi Watanabe Source Type: research
Pathological analysis of lesions in the exocrine pancreas of rats induced by Zinc Maltol
In conclusion, we provided a detailed description of ZM-induced pancreatic lesions in SD rats.PMID:37868114 | PMC:PMC10585244 | DOI:10.1293/tox.2023-0063 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Sakura Fujiwara Takayasu Moroki Masaya Hitomi Makoto Sato Yui Terayama Tsuyoshi Yoshikawa Source Type: research
Histopathology of fused triplet placenta in rat
J Toxicol Pathol. 2023 Oct;36(4):187-192. doi: 10.1293/tox.2023-0026. Epub 2023 Jun 5.ABSTRACTA fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each placenta (referred to as PL-A, PL-B, and PL-C) of this fused placenta was attached to one fetus each, but their fetal weights were lower than that of the fetus attached to the only normal placenta (referred to as PL-N) in this dam. Histopathologically, thinning of the trophoblastic septa and dilatation of the maternal sinusoid in the labyrinth zone were observed in PL-B and PL-C, but not in PL-A or PL-N. The points of placental fusion were at ...
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Satoshi Furukawa Naho Tsuji Seigo Hayashi Yusuke Kuroda Masayuki Kimura Chisato Kojima Kazuya Takeuchi Source Type: research
Retraction: Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed < em > In Utero < /em > to Di( < em > n < /em > -butyl) Phthalate
J Toxicol Pathol. 2023 Oct;36(4):212. doi: 10.1293/tox.36.R1. Epub 2023 Oct 6.ABSTRACT[This retracts the article on p. 439 in vol. 26, PMID: 24526819.].PMID:37868116 | PMC:PMC10585245 | DOI:10.1293/tox.36.R1 (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - October 23, 2023 Category: Toxicology Authors: Shin Wakui Masaya Motohashi Takemi Satoh Masaru Shirai Tomoko Mutou Hiroyuki Takahashi Michael F Wempe Hitoshi Endou Tomoo Inomata Masao Asari Source Type: research
