Oral Administration of Apple Pectin Solution Improves Atopic Dermatitis in a Mouse Model
In this study, we investigated the effect of oral apple pectin administration on skin inflammation in an AD mouse model and examined changes in T cells involved in AD. To induce AD, a picryl chloride solution was applied to the shaved back skin of male NC/Nga mice. AD mice then received an oral apple pectin solution (0.4% or 4%) for 35 d. Compared with untreated AD mice, mice in both apple pectin-treated groups showed improvement in AD-induced inflammation and skin symptoms. Histological evaluation showed that apple pectin treatment attenuated epidermal thickening and decreased the number of mast cells and CD4+ cells in AD...
Source: Journal of Nutritional Science and Vitaminology - February 28, 2024 Category: Nutrition Authors: Asuka Fujisaki Aya Matsui Kosuke Shiki Rika Tateishi Tatsuki Itoh Source Type: research

Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice
J Nutr Sci Vitaminol (Tokyo). 2024;70(1):1-8. doi: 10.3177/jnsv.70.1.ABSTRACTNiacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity. Since niacin deficiency has been reported in alcoholic patients, and niacin coenzyme NAD is used as substrate to dehydrogenate ethanol in the liver, ethanol consumption can be a factor to impair niacin nutritional status. We have recently established the niacin insufficient model mice using kynurenine 3-monooxygenase knock out (KMO-/-) mice with niacin-limited diet, which lack the de novo NAD synthesis pathway from tryptophan. To ...
Source: Journal of Nutritional Science and Vitaminology - February 28, 2024 Category: Nutrition Authors: Amane Mizutani Chihiro Goto Hidetsugu Fujigaki Yasuko Yamamoto Kuniaki Saito Sho Hatayama Tsutomu Fukuwatari Source Type: research

Cholesterol-Lowering and Antioxidant Effects of Pork-Liver Protein Hydrolysate in Otsuka Long-Evans Tokushima Fatty Rats
In this study, we investigated the effects of a porcine liver protein hydrolysate (PLH) diet on lipid metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type II diabetes. OLETF rats (20-wk-old males) were pair-fed with either a PLH diet containing 20% PLH or a casein diet for 14 wk. Dietary PLH significantly lowered serum cholesterol and phospholipid concentrations, mainly by decreasing low-density lipoprotein and high-density lipoprotein fractions. Fecal cholesterol was significantly increased in the PLH diet group; however, the total bile acid concentration in the feces was not significantly differe...
Source: Journal of Nutritional Science and Vitaminology - February 28, 2024 Category: Nutrition Authors: Muneshige Shimizu Shin Kamiyama Hideyuki Sone Toshihide Nishimura Source Type: research

Investigation of Amino Acid and Fatty Acid Profiles of Japanese Diets Using the Food Exchange Lists for Diabetes Diet
This study suggests the importance of evaluating diet using AA and FA units.PMID:38417849 | DOI:10.3177/jnsv.70.25 (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - February 28, 2024 Category: Nutrition Authors: Ayari Tsumura Hisami Yamanaka-Okumura Hana Kawakami Shiori Yamamoto Mayu Oura Hiroshi Tatano Hirokazu Ohminami Masashi Masuda Yutaka Taketani Source Type: research

Antioxidant Vitamin Intake and LOX-Index in Japanese Municipal Workers
J Nutr Sci Vitaminol (Tokyo). 2024;70(1):36-43. doi: 10.3177/jnsv.70.36.ABSTRACTAntioxidant vitamin intake has been reported to be associated with decreased risk of cardiovascular diseases. To date, however, no study has examined the association between antioxidant vitamin intake and LOX-index, a predictive biomarker of cardiovascular disease. We investigated the cross-sectional association between antioxidant vitamin (α-carotene, β-carotene, α-tocopherol, and vitamin C) intake and LOX-index in Japanese municipal workers. Participants were 346 workers (171 men and 175 women aged 19-71 y) who received a health check-up a...
Source: Journal of Nutritional Science and Vitaminology - February 28, 2024 Category: Nutrition Authors: Mirai Sakanari Masanori Ohta Mayumi Nagano Yoko Umeki Akiko Nanri Source Type: research