SMARCB1-Retained and SMARCB1-Deficient SNUC are Genetically Distinct: A Pilot Study Using RNA Sequencing
Conclusion RNA sequencing is a viable and informative approach for genomic profiling of archival SNUC samples. Both SR-SNUC and SD-SNUC were noted to have distinct genetic profiles underlying the molecular classification of these diseases. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - June 12, 2023 Category: Neurosurgery Authors: Chitguppi, Chandala Rosen, Marc Nyquist, Gurston Toskala, Elina Evans, James Gargano, Stacey Tuluc, Madalina Ertel, Adam Dsouza, Glen Addya, Sankar Johnson, Jennifer Bar-Ad, Voichita Rabinowitz, Mindy Tags: Original Article Source Type: research

SMARCB1-Retained and SMARCB1-Deficient SNUC are Genetically Distinct: A Pilot Study Using RNA Sequencing
Conclusion RNA sequencing is a viable and informative approach for genomic profiling of archival SNUC samples. Both SR-SNUC and SD-SNUC were noted to have distinct genetic profiles underlying the molecular classification of these diseases. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - June 12, 2023 Category: Neurosurgery Authors: Chitguppi, Chandala Rosen, Marc Nyquist, Gurston Toskala, Elina Evans, James Gargano, Stacey Tuluc, Madalina Ertel, Adam Dsouza, Glen Addya, Sankar Johnson, Jennifer Bar-Ad, Voichita Rabinowitz, Mindy Tags: Original Article Source Type: research

Transcriptome-Derived Ligand-Receptor Interactome of Major PitNET Subgroups
Conclusion Relative crosstalk score analysis revealed a great diversity of LR complex interactions across clinical PitNET subtypes and between solid tumor compartments. More data are needed to validate these findings and exact clinical importance. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - June 12, 2023 Category: Neurosurgery Authors: Batchu, Sai Diaz, Michael Joseph Patel, Aashay Reddy, Akshay Lucke-Wold, Brandon Tags: Original Article Source Type: research

Impact of Latency Variations on the Predictive Value of Facial Nerve Proximal-to-Distal Amplitude Ratio during Vestibular Schwannoma Surgery
Conclusion At a latency between 6 and 8 ms, the P/D amplitude ratio was predictive of outcomes with high SE and SP. When latency was < 6 ms or > 8 ms, the same predictive ability was not observed. Knowing the strengths and limitations is important for understanding the predictive value of the P/D amplitude ratio. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - June 12, 2023 Category: Neurosurgery Authors: Ashram, Yasmine A. Zohdy, Youssef M. Garzon-Muvdi, Tomas Tags: Original Article Source Type: research

NextLens —The Next Generation of Surgical Navigation: Proof of Concept of an Augmented Reality System for Surgical Navigation
Conclusion The HoloLens 2 has a high potential for use as a surgical navigation system. With subsequent studies, a further accuracy evaluation will be performed receiving valid data for comparison with conventional surgical navigation systems. In addition to transsphenoidal pituitary surgery, it could be also applied for other surgical disciplines. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - June 1, 2023 Category: Neurosurgery Authors: Grunert, Ronny Snyderman, Carl-Henry Gardner, Paul Busse, Michel Ahner, Lukas Kropla, Fabian M öbius, Robert Jung, Svenja Scholz, Sebastian G üresir, Erdem Winkler, Dirk Tags: Original Article Source Type: research

Frontotemporal Orbitozygomatic Transcavernous Approach: Stepwise Cadaveric Dissection for a Safe Corridor
Conclusion Despite its technical difficulty, the FTOZ TCA should be considered for the surgical management of basilar apex aneurysms and tumors surrounding the cavernous sinus, sellar/parasellar, retrochiasmatic, and petroclival region. Continuous training and dedicated time in the skull base laboratory can help achieve the necessary skills required to perform this approach. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - June 1, 2023 Category: Neurosurgery Authors: Corecha Santos, Romel Gupta, Bhavika Dabecco, Rocco Santiago, Raphael Bastianon Kaye, Brandon Borghei-Razavi, Hamid Adada, Badih Tags: Original Article Source Type: research

A Study on the Efficacy of Thrombectomy in Patients with Atherosclerotic and Cardioembolic Basilar Artery Occlusion
Conclusions Although there were differences in clinical characteristics and imaging features between LAA and CE, there was no evidence of a significant difference in prognosis after EVT. In addition, the National Institutes of Health Stroke Scale score was not among the independent risk factors affecting the prognosis of the LAA group. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - June 1, 2023 Category: Neurosurgery Authors: Chen, Fulei Dai, Linzhi Dong, Jiangtao Zhu, Licang Li, Yang Zhang, Lei Zhao, Dong Tags: Original Article Source Type: research

Multiportal Retrograde Endoscopy to Enhance Surgical Target Visualization: A Pilot Study
Conclusion High-quality visualization of surgical targets such as the frontal or maxillary ostia can be challenging with rigid endoscopes alone. Multiportal retrograde endoscopy provides proof of concept that additional views of a surgical target can be achieved. Additional work is needed to further develop indications, techniques, and generalizability to targets beyond those investigated here. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 31, 2023 Category: Neurosurgery Authors: Konuthula, Neeraja Bly, Randall A. Abuzeid, Waleed M. Humphreys, Ian M. Masco, Vanessa V. Hannaford, Blake Moe, Kris S. Tags: Original Article Source Type: research

Endocrine Outcomes and Associated Predictive Factors for Somatotrophin Pituitary Adenoma after Endoscopic Endonasal Transsphenoidal Surgery: 10 Years of Experience in a Single Institute
Conclusion The surgeons' experience is an important factor that can affect the patients' endocrine outcomes after surgery. The macroadenomas with lateral invasion are more difficult to cure. Patients with higher preoperative nadir GH levels are less likely to achieve remission. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 30, 2023 Category: Neurosurgery Authors: Geng, Yuanming Dong, Qian Cong, Zixiang Zhu, Junhao Li, Zhenxing Du, Chaonan Yuan, Feng Zeng, Xinrui Ali, Alleyar Yang, Jin Tang, Chao Ma, Chiyuan Tags: Original Article Source Type: research

Clinical Outcome in Patients with Large Sinonasal Tumors with Intracranial Extension
Conclusion In conclusion, the overall survival was 50% for this group of patients with large sinonasal tumors. Progressive disease affects survival rate severely. Surgical complications were seen in five (28%) patients. Radiotherapy is associated with high complication rates. Radiation necrosis was a serious complication in two patients and could be treated with high dose steroids. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 24, 2023 Category: Neurosurgery Authors: Keizer, Max E. Hovinga, Koos E. Lacko, Martin Eekers, Danielle B.P. Baijens, Laura W.J. Kremer, Bernd Temel, Yasin Tags: Original Article Source Type: research

Suprasellar Meningioma Classification: Endoscopic Transnasal Perspective
Conclusions Preoperative evaluation of bone involvement and tumor relation to neurovascular structures can be used to classify suprasellar meningiomas. Chiasmatic sulcus meningioma is a distinct subtype of suprasellar meningiomas. Its unique behavior toward nearby neurovascular structures could be of surgical value during tumor resection. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 24, 2023 Category: Neurosurgery Authors: Ajlan, Abdulrazag Noor Elahi, Basim Almeshari, Saif Basindwah, Sarah Alghabban, Fatimah Abdulrahim Alromaih, Saud Alroqi, Ahmad Alrasheed, Abdulaziz S. Alqurashi, Ashwag Alsaleh, Saad Tags: Original Article Source Type: research

Thank You and Welcome to the New Editors of JNLS Reports
J Neurol Surg B Skull Base DOI: 10.1055/s-0043-1769002 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 23, 2023 Category: Neurosurgery Authors: Kraus, Dennis Link, Michael J. Tags: Thank You Note Source Type: research

Soft Tissue Dissection in the Transcondylar Approach: A Modified Layered Technique to Maximize Lateral Access
Conclusions This technique avoids the obstructive muscle bulk that results from a myocutaneous approach while maximizing deep exposure. Understanding the detailed muscular anatomical relationship with the insertion location and suboccipital nerves is key to complete and safe extracranial dissection. Diligent dissection helps minimize postoperative pain and muscle spasm while optimizing the closure technique. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 19, 2023 Category: Neurosurgery Authors: Zhao, Xiaochun Prather, Kiana Y. Tavakol, Sherwin A. Pelargos, Panayiotis E. Dunn, Ian F. Tags: Technical Note Source Type: research

Surgical Management of Large ( ≥3 cm) Trigeminal Schwannomas: Functional Outcomes and Approach Selection in Multicompartmental Schwannomas
Conclusions Large-volume schwannomas present with cranial nerve involvement and may need extensive skull base approaches. Functional outcomes need to be prioritized and can be achieved albeit with lesser gross resection rates. Hearing and facial preservation in addition to relief of trigeminal symptoms should be the goal of resection with minimal additional morbidity. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 17, 2023 Category: Neurosurgery Authors: Dwarakanath, Srinivas Deora, Harsh Mehta, Sarthak Shukla, Dhaval A., Arivazhagan Rao, KVLN Somanna, Sampath Tags: Original Article Source Type: research

Pain Outcomes Following Endoscopic Microvascular Decompression for Trigeminal Neuralgia Based on Vascular Compression Type
Conclusions The degree of clinical improvement in all types of VC was excellent, but at longest follow-up VC type was not a significant predictor out outcome. However distal venous compression was significantly associated with worse outcomes at 1 month. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 11, 2023 Category: Neurosurgery Authors: Blue, Rachel Yang, Andrew I. Ajmera, Sonia Spadola, Michael Howard, Susanna Saylany, Anissa Kvint, Svetlana Harber, Alexander Daly, Megan Shekhtman, Emily Nair, Anjana Deshpande, Riddhi Lee, John Y.K. Tags: Original Article Source Type: research