Substance Use after Completion of an Intensive Treatment Program with Concurrent Treatment for Posttraumatic Stress Disorder and Substance Use among Veterans: Examining the Role of PTSD Symptoms
Conclusions: Concurrent intensive treatment of PTSD and SUDs can lead to symptom improvement in a short period of time. Findings support the self-medication model, such that PTSD symptoms at treatment completion were related to substance use at follow-up.PMID:38122816 | DOI:10.1080/15504263.2023.2290167 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Laura E Watkins Samantha C Patton Tiffany Wilcox Karen Drexler Sheila A M Rauch Barbara O Rothbaum Source Type: research
Integrative Pharmacology in the Treatment of Substance Use Disorders
This article aims to review the neurobiology that integrates many pathophysiologic mechanisms and discuss integrative pharmacology developments that may ultimately improve clinical outcomes for patients with SUDs. Many neurobiological mechanisms are known to be involved in SUDs including dopaminergic, nicotinic, N-methyl-D-aspartate (NMDA), and kynurenic acid (KYNA) mechanisms. Emerging evidence indicates that KYNA, a tryptophan metabolite, modulates all these major pathophysiologic mechanisms. Therefore, achieving KYNA homeostasis by harmonizing integrative pathophysiology and pharmacology could prove to be a better thera...
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Jack Donlon Pooja Kumari Sajoy P Varghese Michael Bai Ori David Florentin Emma D Frost John Banks Niyathi Vadlapatla Olivia Kam Mujeeb U Shad Shafiqur Rahman Osama A Abulseoud Trevor W Stone Maju Mathew Koola Source Type: research
Substance Use after Completion of an Intensive Treatment Program with Concurrent Treatment for Posttraumatic Stress Disorder and Substance Use among Veterans: Examining the Role of PTSD Symptoms
Conclusions: Concurrent intensive treatment of PTSD and SUDs can lead to symptom improvement in a short period of time. Findings support the self-medication model, such that PTSD symptoms at treatment completion were related to substance use at follow-up.PMID:38122816 | DOI:10.1080/15504263.2023.2290167 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Laura E Watkins Samantha C Patton Tiffany Wilcox Karen Drexler Sheila A M Rauch Barbara O Rothbaum Source Type: research
Integrative Pharmacology in the Treatment of Substance Use Disorders
This article aims to review the neurobiology that integrates many pathophysiologic mechanisms and discuss integrative pharmacology developments that may ultimately improve clinical outcomes for patients with SUDs. Many neurobiological mechanisms are known to be involved in SUDs including dopaminergic, nicotinic, N-methyl-D-aspartate (NMDA), and kynurenic acid (KYNA) mechanisms. Emerging evidence indicates that KYNA, a tryptophan metabolite, modulates all these major pathophysiologic mechanisms. Therefore, achieving KYNA homeostasis by harmonizing integrative pathophysiology and pharmacology could prove to be a better thera...
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Jack Donlon Pooja Kumari Sajoy P Varghese Michael Bai Ori David Florentin Emma D Frost John Banks Niyathi Vadlapatla Olivia Kam Mujeeb U Shad Shafiqur Rahman Osama A Abulseoud Trevor W Stone Maju Mathew Koola Source Type: research
Substance Use after Completion of an Intensive Treatment Program with Concurrent Treatment for Posttraumatic Stress Disorder and Substance Use among Veterans: Examining the Role of PTSD Symptoms
Conclusions: Concurrent intensive treatment of PTSD and SUDs can lead to symptom improvement in a short period of time. Findings support the self-medication model, such that PTSD symptoms at treatment completion were related to substance use at follow-up.PMID:38122816 | DOI:10.1080/15504263.2023.2290167 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Laura E Watkins Samantha C Patton Tiffany Wilcox Karen Drexler Sheila A M Rauch Barbara O Rothbaum Source Type: research
Integrative Pharmacology in the Treatment of Substance Use Disorders
This article aims to review the neurobiology that integrates many pathophysiologic mechanisms and discuss integrative pharmacology developments that may ultimately improve clinical outcomes for patients with SUDs. Many neurobiological mechanisms are known to be involved in SUDs including dopaminergic, nicotinic, N-methyl-D-aspartate (NMDA), and kynurenic acid (KYNA) mechanisms. Emerging evidence indicates that KYNA, a tryptophan metabolite, modulates all these major pathophysiologic mechanisms. Therefore, achieving KYNA homeostasis by harmonizing integrative pathophysiology and pharmacology could prove to be a better thera...
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Jack Donlon Pooja Kumari Sajoy P Varghese Michael Bai Ori David Florentin Emma D Frost John Banks Niyathi Vadlapatla Olivia Kam Mujeeb U Shad Shafiqur Rahman Osama A Abulseoud Trevor W Stone Maju Mathew Koola Source Type: research
Substance Use after Completion of an Intensive Treatment Program with Concurrent Treatment for Posttraumatic Stress Disorder and Substance Use among Veterans: Examining the Role of PTSD Symptoms
Conclusions: Concurrent intensive treatment of PTSD and SUDs can lead to symptom improvement in a short period of time. Findings support the self-medication model, such that PTSD symptoms at treatment completion were related to substance use at follow-up.PMID:38122816 | DOI:10.1080/15504263.2023.2290167 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Laura E Watkins Samantha C Patton Tiffany Wilcox Karen Drexler Sheila A M Rauch Barbara O Rothbaum Source Type: research
Associations among Trauma Exposure, Post-Traumatic Stress Symptoms and Alcohol Use in Black/African American Treatment-Seeking Adults
CONCLUSIONS: Results from the test of indirect effects suggest that among Black/AA adults with heavy alcohol use and trauma exposure, trauma exposure is associated with PTSD symptoms, which in turn is associated with quantity of alcohol use. These findings are consistent with research conducted with White/mixed groups and align with tenets of the self-medication model of PTSD-AUD comorbidity. These findings support current practices that highlight the importance of screening for and addressing PTSD and alcohol use in individuals exposed to trauma. Findings from this paper provide initial data on understudied relationships ...
Source: Journal of Dual Diagnosis - December 19, 2023 Category: Addiction Authors: Dezarie Moskal Melanie E Bennett Russell M Marks Daniel J O Roche Source Type: research
Co-Occurring Posttraumatic Stress Disorder Symptoms and Alcohol Use Behaviors: The Mediating Role of Drinking to Cope with PTSD Symptoms
CONCLUSIONS: Findings will be discussed with regard to previous and future research.PMID:37851919 | DOI:10.1080/15504263.2023.2260326 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - October 18, 2023 Category: Addiction Authors: Mara L Ferrie Abby Lheureux Anka A Vujanovic Michael J Zvolensky Amanda M Raines Source Type: research
