A Harm Reduction Framework for Integrated Treatment of Co-Occurring Opioid Use Disorder and Trauma-Related Disorders
J Dual Diagn. 2024 Jan 2:1-34. doi: 10.1080/15504263.2023.2295416. Online ahead of print.ABSTRACTThe opioid epidemic has exposed a gulf in mental health research, treatment, and policy: Most patients with comorbid trauma-related disorder (TRD) and opioid use disorder (OUD) (TRD + OUD) remain undiagnosed or unsuccessfully treated for the combination of TRD symptoms and opioid use. TRD treatments tend to be psychotherapies that are not accessible or practical for many individuals with TRD + OUD, due to TRD treatment models not systematically incorporating principles of harm reduction (HR). HR practices prioritize flexibility...
Source: Journal of Dual Diagnosis - January 2, 2024 Category: Addiction Authors: Benjamin S Israel Annabelle M Belcher Julian D Ford Source Type: research
Prevalence, Characteristics, and Reasons for Kratom Use among Psychiatrically Ill Inpatients Who Use Substances
CONCLUSIONS: Prevalence of kratom use among patients with serious mental illness at our site aligns with that reported in the general population. Users often cite self-management of cravings and sobriety from opioids, as well as treatment of low mood states, as motivations for consumption. While observations suggest a possible association between kratom use and individuals with post-secondary education, multiple substance use, and experience of substance-induced psychosis or mood disorders, it is essential to interpret these links cautiously until further rigorous studies are carried out to substantiate these findings.PMID...
Source: Journal of Dual Diagnosis - December 28, 2023 Category: Addiction Authors: Cornel N Stanciu Saeed Ahmed Zouina Sarfraz Nirav Nimavat Christopher J Healey Oliver Grundmann Jonathan R Ballard Jack Henningfield Source Type: research
Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder - A Pilot Study
Conclusions: The findings from this study demonstrate that progesterone can be effective in reducing stress-induced craving, anxiety and negative affect in a laboratory setting in individuals with comorbid AUD and PTSD. Interestingly, progesterone also improved cognitive performance. These findings require replication in a larger clinical trial and may have implications for treatment among individuals with AUD and PTSD.This study was registered as NCT02187224, at www.clinicaltrials.gov.PMID:38147491 | DOI:10.1080/15504263.2023.2294989 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - December 26, 2023 Category: Addiction Authors: Elizabeth Ralevski Jenelle Newcomb Emily Pisani Diana DeNegre MacKenzie Peltier Jane Serrita Jane Gihyun Yoon Ismene Petrakis Source Type: research
Examining the Temporal Relation between Posttraumatic Stress Symptoms and Heavy Drinking among Veterans Receiving Mental Health Treatment in Primary Care
CONCLUSIONS: The current study evidenced mixed support for the temporal precedence of PTSS and alcohol misuse. Relations between PTSS and heavy drinking appeared to be linked to treatment targets within PC-TIME and varied between treatment condition (PC-TIME versus PC-TAU). Notably, those with greater than average heavy drinking at the initiation of integrated treatment appeared to have greater reductions in PTSS at post-treatment. Results suggest a mutual maintenance model may best characterize the association between co-occurring PTSS and heavy drinking among treatment-seeking individuals.PMID:38145623 | DOI:10.1080/1550...
Source: Journal of Dual Diagnosis - December 25, 2023 Category: Addiction Authors: Christina Balderrama-Durbin Eileen P Barden Melissa V Gates Jessica Hill Nadine R Mastroleo Kyle Possemato Paul R King Sheila A M Rauch Source Type: research
Integrative Pharmacology in the Treatment of Substance Use Disorders
This article aims to review the neurobiology that integrates many pathophysiologic mechanisms and discuss integrative pharmacology developments that may ultimately improve clinical outcomes for patients with SUDs. Many neurobiological mechanisms are known to be involved in SUDs including dopaminergic, nicotinic, N-methyl-D-aspartate (NMDA), and kynurenic acid (KYNA) mechanisms. Emerging evidence indicates that KYNA, a tryptophan metabolite, modulates all these major pathophysiologic mechanisms. Therefore, achieving KYNA homeostasis by harmonizing integrative pathophysiology and pharmacology could prove to be a better thera...
Source: Journal of Dual Diagnosis - December 20, 2023 Category: Addiction Authors: Jack Donlon Pooja Kumari Sajoy P Varghese Michael Bai Ori David Florentin Emma D Frost John Banks Niyathi Vadlapatla Olivia Kam Mujeeb U Shad Shafiqur Rahman Osama A Abulseoud Trevor W Stone Maju Mathew Koola Source Type: research
