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Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulation
J Clin Biochem Nutr. 2024 Mar;74(2):91-96. doi: 10.3164/jcbn.23-106. Epub 2023 Nov 22.ABSTRACTTranscription is regulated by specific transcription factors that mediate signaling in response to extrinsic and intrinsic stimuli such as nutrients, hormones, and oxidative stresses. Many transcription factors are grouped based on their highly conserved DNA binding domains. Consequently, transcription factors within the same family often exhibit functional redundancy and compensation. NRF2 (NFE2L2) and NRF1 (NFE2L1) belong to the CNC family transcription factors, which are responsible for various stress responses. Although their ...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Hiroki Sekine Hozumi Motohashi Source Type: research

High-intensity exercise impairs intestinal barrier function by generating oxidative stress
In this study, we examined the involvement of oxidative stress in barrier function of the ileum of mice following high-intensity exercise. Male ICR mice (12-week-old) were divided into sedentary and exercise groups. Mice in the exercise group underwent a single bout of treadmill running, and the ileum was collected for histological and biochemical analyses. Plasma fluorescence intensity level after oral administration of fluorescein isothiocyanate-dextran gradually increased until 30 min after exercise in response to intensity of exercise. Relatively high levels of oxidative proteins and low level of claudin-1, a tight-jun...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Maki Takami Wataru Aoi Karin Matsumoto Yoji Kato Yukiko Kobayashi Masashi Kuwahata Source Type: research

Prosaposin is a novel coenzyme Q10-binding protein
J Clin Biochem Nutr. 2024 Mar;74(2):108-112. doi: 10.3164/jcbn.23-57. Epub 2023 Nov 8.ABSTRACTCoenzyme Q10 (CoQ10) is essential for mitochondrial ATP production and functions as an important antioxidant in every biomembrane and lipoprotein. Due to its hydrophobicity, a binding and transfer protein for CoQ10 is plausible, and we previously described saposin B as a CoQ10-binding and transfer protein. Here, we report that prosaposin, the precursor of saposin B, also binds CoQ10. As prosaposin is both a secretory protein and integral membrane protein, it is ubiquitous in the body. Prosaposin was isolated from human seminal pla...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Makoto Hasegawa Yorihiro Yamamoto Akio Fujisawa Misato Kashiba Source Type: research

Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation
In this study, we established Tamoxifen-inducible GPx4-deficient Mouse embryonic fibroblast (MEF) cells (ETK1 cells) and found that Tamoxifen-inducible gene disruption of GPx4 induces slow cell death at ~72 h. In contrast, RSL3- or erastin-induced ferroptosis occurred quickly within 24 h. Therefore, we investigated the differences in these mechanisms between GPx4 gene disruption-induced cell death and RSL3- or erastin-induced ferroptosis. We found that GPx4-deficiency induced lipid peroxidation at 24 h in Tamoxifen-treated ETK1 cells, which was not suppressed by iron chelators, although lipid peroxidation in RSL3- or erast...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Kahori Tsuruta Masaki Matsuoka Shinsaku Harada Ayaka Enomoto Takeshi Kumagai Shu Yasuda Tomoko Koumura Ken-Ichi Yamada Hirotaka Imai Source Type: research

Improvement trend for individual health guidance intervention according to Japan clinical guidelines by public health nurses for type 2 diabetes mellitus who visited for medical checkups regularly: a case-control preliminary report
In conclusion, the implementation of individual health guidance interventions may prove to be effective for individuals with type 2 diabetes mellitus and obesity who regularly attend medical checkups.PMID:38510680 | PMC:PMC10948351 | DOI:10.3164/jcbn.23-52 (Source: Journal of Clinical Biochemistry and Nutrition)
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Rina Matsuo Tomohiro Imamura Ayako Takamori Takuya Kishi Miwako Minami Junko Miyakawa Natsuki Yoshitake Ai Hayashi Yuki Nakayama Natsumi Egashira Minako Teramoto Hiroko Ishinari Itsuka Kajiyama Satomi Fujisaki Hitomi Kakiyama Kanako Satou Rei Nakafusa Chi Source Type: research