Journal of Biological Inorganic Chemistry : JBIC 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Collaborations in the Spanish-Speaking Bioinorganic Community
J Biol Inorg Chem. 2024 Mar 22. doi: 10.1007/s00775-024-02047-z. Online ahead of print.NO ABSTRACTPMID:38517517 | DOI:10.1007/s00775-024-02047-z (Source: Journal of Biological Inorganic Chemistry : JBIC)
Source: Journal of Biological Inorganic Chemistry : JBIC - March 22, 2024 Category: Chemistry Authors: Patrick Gamez Luis Lemus Source Type: research
Mononuclear η < sup > 6 < /sup > -arene ruthenium(II) complexes with pyrazolyl-pyridazine ligands: synthesis, CT-DNA binding, reactivity towards glutathione, and cytotoxicity
J Biol Inorg Chem. 2024 Mar 17. doi: 10.1007/s00775-024-02043-3. Online ahead of print.ABSTRACTOrganometallic η6-arene ruthenium(II) complexes with 3-chloro-6-(1H-pyrazol-1-yl)pyridazine (Ru1, Ru2, and Ru5) and 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (Ru3-4) N,N' heterocyclic and η6-arene (cymene (Ru1-4) or toluene (Ru 5)) have been synthesized. The ruthenium(II) complexes have common "three-legged piano-stool" pseudo-octahedral structures known for half-sandwich complexes. Evolution of their UV-Visible absorption spectra in PBS buffer or DMSO over 24 h confirmed their good solvolysis stability. Titrations of...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 18, 2024 Category: Chemistry Authors: Amos K Kanyora Reinner O Omondi Peter Ongoma Josiah O Omolo Athi Welsh Sharon Prince Joel Gichumbi Allen Mambanda Gregory S Smith Source Type: research
Mononuclear η < sup > 6 < /sup > -arene ruthenium(II) complexes with pyrazolyl-pyridazine ligands: synthesis, CT-DNA binding, reactivity towards glutathione, and cytotoxicity
J Biol Inorg Chem. 2024 Mar 17. doi: 10.1007/s00775-024-02043-3. Online ahead of print.ABSTRACTOrganometallic η6-arene ruthenium(II) complexes with 3-chloro-6-(1H-pyrazol-1-yl)pyridazine (Ru1, Ru2, and Ru5) and 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (Ru3-4) N,N' heterocyclic and η6-arene (cymene (Ru1-4) or toluene (Ru 5)) have been synthesized. The ruthenium(II) complexes have common "three-legged piano-stool" pseudo-octahedral structures known for half-sandwich complexes. Evolution of their UV-Visible absorption spectra in PBS buffer or DMSO over 24 h confirmed their good solvolysis stability. Titrations of...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 18, 2024 Category: Chemistry Authors: Amos K Kanyora Reinner O Omondi Peter Ongoma Josiah O Omolo Athi Welsh Sharon Prince Joel Gichumbi Allen Mambanda Gregory S Smith Source Type: research
Mononuclear η < sup > 6 < /sup > -arene ruthenium(II) complexes with pyrazolyl-pyridazine ligands: synthesis, CT-DNA binding, reactivity towards glutathione, and cytotoxicity
J Biol Inorg Chem. 2024 Mar 17. doi: 10.1007/s00775-024-02043-3. Online ahead of print.ABSTRACTOrganometallic η6-arene ruthenium(II) complexes with 3-chloro-6-(1H-pyrazol-1-yl)pyridazine (Ru1, Ru2, and Ru5) and 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (Ru3-4) N,N' heterocyclic and η6-arene (cymene (Ru1-4) or toluene (Ru 5)) have been synthesized. The ruthenium(II) complexes have common "three-legged piano-stool" pseudo-octahedral structures known for half-sandwich complexes. Evolution of their UV-Visible absorption spectra in PBS buffer or DMSO over 24 h confirmed their good solvolysis stability. Titrations of...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 18, 2024 Category: Chemistry Authors: Amos K Kanyora Reinner O Omondi Peter Ongoma Josiah O Omolo Athi Welsh Sharon Prince Joel Gichumbi Allen Mambanda Gregory S Smith Source Type: research
Mononuclear η < sup > 6 < /sup > -arene ruthenium(II) complexes with pyrazolyl-pyridazine ligands: synthesis, CT-DNA binding, reactivity towards glutathione, and cytotoxicity
J Biol Inorg Chem. 2024 Mar 17. doi: 10.1007/s00775-024-02043-3. Online ahead of print.ABSTRACTOrganometallic η6-arene ruthenium(II) complexes with 3-chloro-6-(1H-pyrazol-1-yl)pyridazine (Ru1, Ru2, and Ru5) and 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (Ru3-4) N,N' heterocyclic and η6-arene (cymene (Ru1-4) or toluene (Ru 5)) have been synthesized. The ruthenium(II) complexes have common "three-legged piano-stool" pseudo-octahedral structures known for half-sandwich complexes. Evolution of their UV-Visible absorption spectra in PBS buffer or DMSO over 24 h confirmed their good solvolysis stability. Titrations of...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 18, 2024 Category: Chemistry Authors: Amos K Kanyora Reinner O Omondi Peter Ongoma Josiah O Omolo Athi Welsh Sharon Prince Joel Gichumbi Allen Mambanda Gregory S Smith Source Type: research
Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation
J Biol Inorg Chem. 2024 Mar 12. doi: 10.1007/s00775-024-02044-2. Online ahead of print.ABSTRACTVariants in the gene encoding human cytochrome c (CYCS) cause mild autosomal dominant thrombocytopenia. Despite high sequence conservation between mouse and human cytochrome c, this phenotype is not recapitulated in mice for the sole mutant (G41S) that has been investigated. The effect of the G41S mutation on the in vitro activities of cytochrome c is also not conserved between human and mouse. Peroxidase activity is increased in both mouse and human G41S variants, whereas apoptosome activation is increased for human G41S cytochr...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 13, 2024 Category: Chemistry Authors: Thomas C Chin Sigurd M Wilbanks Elizabeth C Ledgerwood Source Type: research
Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation
J Biol Inorg Chem. 2024 Mar 12. doi: 10.1007/s00775-024-02044-2. Online ahead of print.ABSTRACTVariants in the gene encoding human cytochrome c (CYCS) cause mild autosomal dominant thrombocytopenia. Despite high sequence conservation between mouse and human cytochrome c, this phenotype is not recapitulated in mice for the sole mutant (G41S) that has been investigated. The effect of the G41S mutation on the in vitro activities of cytochrome c is also not conserved between human and mouse. Peroxidase activity is increased in both mouse and human G41S variants, whereas apoptosome activation is increased for human G41S cytochr...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 13, 2024 Category: Chemistry Authors: Thomas C Chin Sigurd M Wilbanks Elizabeth C Ledgerwood Source Type: research
Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation
J Biol Inorg Chem. 2024 Mar 12. doi: 10.1007/s00775-024-02044-2. Online ahead of print.ABSTRACTVariants in the gene encoding human cytochrome c (CYCS) cause mild autosomal dominant thrombocytopenia. Despite high sequence conservation between mouse and human cytochrome c, this phenotype is not recapitulated in mice for the sole mutant (G41S) that has been investigated. The effect of the G41S mutation on the in vitro activities of cytochrome c is also not conserved between human and mouse. Peroxidase activity is increased in both mouse and human G41S variants, whereas apoptosome activation is increased for human G41S cytochr...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 13, 2024 Category: Chemistry Authors: Thomas C Chin Sigurd M Wilbanks Elizabeth C Ledgerwood Source Type: research
Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation
J Biol Inorg Chem. 2024 Mar 12. doi: 10.1007/s00775-024-02044-2. Online ahead of print.ABSTRACTVariants in the gene encoding human cytochrome c (CYCS) cause mild autosomal dominant thrombocytopenia. Despite high sequence conservation between mouse and human cytochrome c, this phenotype is not recapitulated in mice for the sole mutant (G41S) that has been investigated. The effect of the G41S mutation on the in vitro activities of cytochrome c is also not conserved between human and mouse. Peroxidase activity is increased in both mouse and human G41S variants, whereas apoptosome activation is increased for human G41S cytochr...
Source: Journal of Biological Inorganic Chemistry : JBIC - March 13, 2024 Category: Chemistry Authors: Thomas C Chin Sigurd M Wilbanks Elizabeth C Ledgerwood Source Type: research
Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion
J Biol Inorg Chem. 2024 Feb 18. doi: 10.1007/s00775-023-02041-x. Online ahead of print.ABSTRACTWe previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(iPr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line. 2-4 were found to exhibit IC50 values of 10.33 ± 0.06 µM, 1.07 ± 0.01 µM and 25.37 ± 0.12 µM, respectively, compared...
Source: Journal of Biological Inorganic Chemistry : JBIC - February 18, 2024 Category: Chemistry Authors: Pit Foong Chan Kok Pian Ang Roslida Abd Hamid Source Type: research
Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion
J Biol Inorg Chem. 2024 Feb 18. doi: 10.1007/s00775-023-02041-x. Online ahead of print.ABSTRACTWe previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(iPr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line. 2-4 were found to exhibit IC50 values of 10.33 ± 0.06 µM, 1.07 ± 0.01 µM and 25.37 ± 0.12 µM, respectively, compared...
Source: Journal of Biological Inorganic Chemistry : JBIC - February 18, 2024 Category: Chemistry Authors: Pit Foong Chan Kok Pian Ang Roslida Abd Hamid Source Type: research
Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion
J Biol Inorg Chem. 2024 Feb 18. doi: 10.1007/s00775-023-02041-x. Online ahead of print.ABSTRACTWe previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(iPr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line. 2-4 were found to exhibit IC50 values of 10.33 ± 0.06 µM, 1.07 ± 0.01 µM and 25.37 ± 0.12 µM, respectively, compared...
Source: Journal of Biological Inorganic Chemistry : JBIC - February 18, 2024 Category: Chemistry Authors: Pit Foong Chan Kok Pian Ang Roslida Abd Hamid Source Type: research
Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion
J Biol Inorg Chem. 2024 Feb 18. doi: 10.1007/s00775-023-02041-x. Online ahead of print.ABSTRACTWe previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(iPr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line. 2-4 were found to exhibit IC50 values of 10.33 ± 0.06 µM, 1.07 ± 0.01 µM and 25.37 ± 0.12 µM, respectively, compared...
Source: Journal of Biological Inorganic Chemistry : JBIC - February 18, 2024 Category: Chemistry Authors: Pit Foong Chan Kok Pian Ang Roslida Abd Hamid Source Type: research
Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion
J Biol Inorg Chem. 2024 Feb 18. doi: 10.1007/s00775-023-02041-x. Online ahead of print.ABSTRACTWe previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(iPr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line. 2-4 were found to exhibit IC50 values of 10.33 ± 0.06 µM, 1.07 ± 0.01 µM and 25.37 ± 0.12 µM, respectively, compared...
Source: Journal of Biological Inorganic Chemistry : JBIC - February 18, 2024 Category: Chemistry Authors: Pit Foong Chan Kok Pian Ang Roslida Abd Hamid Source Type: research
Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion
J Biol Inorg Chem. 2024 Feb 18. doi: 10.1007/s00775-023-02041-x. Online ahead of print.ABSTRACTWe previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(iPr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line. 2-4 were found to exhibit IC50 values of 10.33 ± 0.06 µM, 1.07 ± 0.01 µM and 25.37 ± 0.12 µM, respectively, compared...
Source: Journal of Biological Inorganic Chemistry : JBIC - February 18, 2024 Category: Chemistry Authors: Pit Foong Chan Kok Pian Ang Roslida Abd Hamid Source Type: research
