Sulfur-bridging the gap: investigating the electrochemistry of novel copper chelating agents for Alzheimer's disease applications
J Biol Inorg Chem. 2023 Aug 18. doi: 10.1007/s00775-023-02013-1. Online ahead of print.ABSTRACTThere is currently an unmet demand for multi-functional precision treatments for Alzheimer's disease (AD) after several failed attempts at designing drugs based on the amyloid hypothesis. The focus of this work is to investigate sulfur-bridged quinoline ligands that could potentially be used in chelation therapies for a subpopulation of AD patients presenting with an overload of labile copper ions, which are known to catalyze the production of reactive oxygen species (ROS) and exacerbate other markers of AD progression. The ligan...
Source: Journal of Biological Inorganic Chemistry : JBIC - August 18, 2023 Category: Chemistry Authors: Emma Crnich Erik Sanchez Mallory A Havens Daniel S Kissel Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Nickel chloride complexes with substituted 4'-phenyl-2',2':6',2 ″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions
J Biol Inorg Chem. 2023 Jul 31. doi: 10.1007/s00775-023-02011-3. Online ahead of print.ABSTRACTA series of Ni(II) sandwich-like coordinated compounds were synthesized by the reaction of nickel dichloride and ten 4'-(4-substituent phenyl)-2',2':6',2″-terpyridine ligands, and their structures were confirmed by elemental analysis, FT-IR, ESI-MS, solid state ultraviolet spectroscopy and X-ray single crystal diffraction analysis. Three human cancer cell lines and a normal human cell line were used for anti-proliferation potential study: human lung cancer cell line (A549), human esophageal cancer cell line (Eca-109), human liv...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 31, 2023 Category: Chemistry Authors: Benwei Wang Dameng Sun Sihan Wang Min Chen Hongming Liu Yanling Zhou Hailan Chen Zhen Ma Source Type: research

Peroxidase activity of rice (Oryza sativa) hemoglobin: distinct role of tyrosines 112 and 151
J Biol Inorg Chem. 2023 Jul 29. doi: 10.1007/s00775-023-02014-0. Online ahead of print.ABSTRACTFive non-symbiotic hemoglobins (nsHb) have been identified in rice (Oryza sativa). Previous studies have shown that stress conditions can induce their overexpression, but the role of those globins is still unclear. To better understand the functions of nsHb, the reactivity of rice Hb1 toward hydrogen peroxide (H2O2) has been studied in vitro. Our results show that recombinant rice Hb1 dimerizes through dityrosine cross-links in the presence of H2O2. By site-directed mutagenesis, we suggest that tyrosine 112 located in the FG loop...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 28, 2023 Category: Chemistry Authors: Val érie Derrien Eric Andr é Sophie Bernad Source Type: research