International Journal of Physiology, Pathophysiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A retrospective comparison of the emergent use of fixed-dose four-factor prothrombin complex versus weight-based dosing for intracranial hemorrhage assessing medication delivery time and cost
CONCLUSIONS: A fixed-dosed strategy reduced time to 4F-PCC administration for warfarin reversal in ICH, as compared to a weight-based strategy; with no increase in LOS, mortality, or need for additional dosing. This also resulted in significant cost savings.PMID:37457648 | PMC:PMC10349319 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Gordon M Riha Michael S Englehart Karin Z Walton Megan E Saunders Benjamin T Carter Simon J Thompson Source Type: research

The protective effect of melatonin on chronic paradoxical sleep deprivation induced metabolic and memory deficit in rats
CONCLUSION: MEL has a protective effect against chronic PSD-induced metabolic malfunction and cognitive deterioration by reducing stress, improving immunity, and maintaining colonic wall integrity.PMID:37457649 | PMC:PMC10349320 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Omyma G Ahmed Ghada S Mahmoud Selvia S Samy Sally A Sayed Source Type: research

Efficacy of 15% lysine cream in treating diabetic foot ulcers: a randomized interventional study
CONCLUSION: The present study demonstrates that a 15% lysine cream can significantly improve wound healing in diabetic foot ulcer patients, as measured by the BWAT, compared to standard treatment alone. Further research is needed to confirm these findings and to explore the underlying mechanisms of lysine's therapeutic effects.PMID:37457650 | PMC:PMC10349317 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Shashikumara Shashikumara Vani Jayaraman Prathima Chikkegowda Darshan Channapatna Lingaiah Bhuvanesh Sukhlal Kalal Source Type: research

HIV-1 envelope protein gp120 modulation of glutamate effects on cortical neuronal synapses: implications for HIV-1-associated neuropathogenesis
Int J Physiol Pathophysiol Pharmacol. 2023 Jun 15;15(3):75-87. eCollection 2023.ABSTRACTDespite the introduction of combined antiretroviral therapy (cART) HIV-1 virus persists in the brain in a latent or restricted manner and viral proteins, such as gp120, continue to play a significant disease-inciting role. Gp120 is known to interact with N-methyl-D-aspartate (NMDA) receptors (NMDARs) resulting in neuronal injury. Glutamate is the main excitatory neurotransmitter in the brain and plays an important role in cognitive function and dysregulation of excitatory synaptic transmission impairs neurocognition. It is our hypothesi...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Jianuo Liu Jinyan Xie Debashis Dutta Huangui Xiong Source Type: research