International Journal of Physiology, Pathophysiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of sleep quality in faculty members of Isfahan university of medical sciences
CONCLUSION: Faculty members exhibited a high prevalence of sleep disorders, with the most common disorders being sleep disturbance and high sleep latency. The prevalence of sleep disorders was higher among basic science faculty members compared to clinicians.PMID:37736504 | PMC:PMC10509560 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 22, 2023 Category: Physiology Authors: Zohre Naderi Babak Amra Fatemeh Ahmadi Mohammad Emami Ardestani Source Type: research

The effect of laser radiation on glial fibrillary acidic protein and allograft inflammatory factor-1 expression in severed and surgically repaired sciatic nerve
CONCLUSIONS: Laser radiation with blue (470 nm) and green (560 nm) spectra, promoted the activation of GFAP-positive Schwann cells and nerve regeneration. Activation of microglia is a necessary component of nerve regeneration and the content of Iba-1 represented the efficiency of regeneration.PMID:37736502 | PMC:PMC10509562 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 22, 2023 Category: Physiology Authors: Zinovii Yashchyshyn Marko Kozyk Kateryna Strubchevska Sergiy Ziablitsev Source Type: research

Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity
Int J Physiol Pathophysiol Pharmacol. 2023 Aug 15;15(4):105-114. eCollection 2023.ABSTRACTObstructive sleep apnea (OSA) is a sleep disorder of significant health concern with a high prevalence in the general population. It has been found to exhibit a high incidence of comorbidity with epilepsy, the exact underlying pathophysiology of which still remains poorly understood. OSA is characterized by apnea/hypopnea spells and arousals, leading to intermittent hypoxemia and sleep deprivation. Both sleep deprivation and hypoxemia adversely affect the cortical excitability and favor epileptogenesis and worsening of pre-existing ep...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 22, 2023 Category: Physiology Authors: Manish Goyal Priyadarshini Mishra Harinder Jaseja Source Type: research

A retrospective comparison of the emergent use of fixed-dose four-factor prothrombin complex versus weight-based dosing for intracranial hemorrhage assessing medication delivery time and cost
CONCLUSIONS: A fixed-dosed strategy reduced time to 4F-PCC administration for warfarin reversal in ICH, as compared to a weight-based strategy; with no increase in LOS, mortality, or need for additional dosing. This also resulted in significant cost savings.PMID:37457648 | PMC:PMC10349319 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Gordon M Riha Michael S Englehart Karin Z Walton Megan E Saunders Benjamin T Carter Simon J Thompson Source Type: research

The protective effect of melatonin on chronic paradoxical sleep deprivation induced metabolic and memory deficit in rats
CONCLUSION: MEL has a protective effect against chronic PSD-induced metabolic malfunction and cognitive deterioration by reducing stress, improving immunity, and maintaining colonic wall integrity.PMID:37457649 | PMC:PMC10349320 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Omyma G Ahmed Ghada S Mahmoud Selvia S Samy Sally A Sayed Source Type: research

Efficacy of 15% lysine cream in treating diabetic foot ulcers: a randomized interventional study
CONCLUSION: The present study demonstrates that a 15% lysine cream can significantly improve wound healing in diabetic foot ulcer patients, as measured by the BWAT, compared to standard treatment alone. Further research is needed to confirm these findings and to explore the underlying mechanisms of lysine's therapeutic effects.PMID:37457650 | PMC:PMC10349317 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Shashikumara Shashikumara Vani Jayaraman Prathima Chikkegowda Darshan Channapatna Lingaiah Bhuvanesh Sukhlal Kalal Source Type: research

HIV-1 envelope protein gp120 modulation of glutamate effects on cortical neuronal synapses: implications for HIV-1-associated neuropathogenesis
Int J Physiol Pathophysiol Pharmacol. 2023 Jun 15;15(3):75-87. eCollection 2023.ABSTRACTDespite the introduction of combined antiretroviral therapy (cART) HIV-1 virus persists in the brain in a latent or restricted manner and viral proteins, such as gp120, continue to play a significant disease-inciting role. Gp120 is known to interact with N-methyl-D-aspartate (NMDA) receptors (NMDARs) resulting in neuronal injury. Glutamate is the main excitatory neurotransmitter in the brain and plays an important role in cognitive function and dysregulation of excitatory synaptic transmission impairs neurocognition. It is our hypothesi...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 17, 2023 Category: Physiology Authors: Jianuo Liu Jinyan Xie Debashis Dutta Huangui Xiong Source Type: research