International Journal of Gynecological Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vulvar Silicone Granuloma
We report a case of vulvar silicone granulomas following injection of liquid silicone into the labia. The patient is a 51-yr-old female who presented with vulvar pain and enlarged, indurated labia majora. In the past, she had undergone bilateral labial cosmetic augmentation with a silicone-based filler injected directly into the labia and into the gluteal regions. This had been performed in a nonmedical setting. At surgery, oblong firm soft tissue masses were removed from both labia. Microscopically, the lesions demonstrated replacement of the subcutaneous adipose tissue by fibrous tissue containing innumerable round empty...
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: CASE REPORTS Source Type: research

Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation
Mesonephric adenocarcinoma is a rare tumor, accounting for (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: CASE REPORTS Source Type: research

Vaginal Low-Grade Endometrial Stromal Sarcoma: An Extremely Rare Case Report and Review of the Literature
Endometrial stromal sarcoma (ESS) is a malignant tumor of the uterus that has been described as the second most common malignant uterine mesenchymal tumor. Primary extrauterine ESS (EESS) is an extremely uncommon occurrence. We hereby report a new bona fide case of low-grade EESS in a 74-yr-old woman arising in the vagina, presenting as a polypoid mass associated with irregular vaginal bleeding. On examination, a 6×2×2 cm polypoid mass was found in the left vaginal wall. Consequently, the patient underwent partial vaginectomy and repair. No ESS or endometriotic lesion was found in the endometrium and bilateral adnexa. ...
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: CASE REPORTS Source Type: research

Intralymphatic Rosai-Dorfman Disease Associated With Vulvar Lymphedema: A Case Report of an Extremely Rare Phenomenon
We report a 16-yr-old female who presented with vaginal swelling and mass-like enlargement of the right labia. The mass had been present for nearly a year without pain or tenderness. Clinically, the lesion was thought to be a Bartholin gland cyst. Following surgical resection, histologic examination demonstrated a hypocellular myxedematous stroma with a mixture of ectatic thin and thick-walled vessels within which there were numerous collections of histiocytes, lymphocytes, and plasma cells. The histopathologic differential diagnosis included localized vulvar lymphedema, a specialized genital tract neoplasm, and childhood ...
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: CASE REPORTS Source Type: research

Clinicopathologic Association and Prognostic Value of MELF Pattern in Invasive Endocervical Adenocarcinoma (ECA) as Classified by IECC
Microcystic, elongated, and fragmented (MELF) pattern of myometrial invasion is correlated with lymphovascular invasion (LVI) and lymph node metastases in uterine endometrioid carcinoma but has not been described in endocervical adenocarcinoma (ECA). A total of 457 ECAs were collected, and clinical/morphologic parameters correlated with follow-up data. Potential associations between MELF pattern and age, human papillomavirus status, tumor size/grade, LVI, lymph node metastases, Silva pattern were analyzed. Statistical analyses of overall survival (OS), disease-free survival, progression-free survival (PFS) were conducted u...
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: ORIGINAL ARTICLES Source Type: research

PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma
Management options are limited in advanced or recurrent cervical carcinoma. The Food and Drug Administration has recently approved programed cell death-1 (PD-1)/PD-ligand-1 (PD-L1) inhibitors for the treatment of advanced PD-L1 positive cervical cancer. We studied PD-L1 expression in cervical squamous cell carcinoma (CSCC) samples initially on a The tissue microarray and then in full-tissue sections from poorly differentiated (grade 3) cancers. Tissue microarray was composed of 45 grade 3 and 2 (moderately differentiated) tumors. PD-L1 expression was evaluated as categorical data and by obtaining combined positive score of...
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: ORIGINAL ARTICLES Source Type: research

Practical Guidance for Measuring and Reporting Surgical Margins in Vulvar Cancer
Surgical resection with free surgical margins is the cornerstone of successful primary treatment of vulvar squamous cell carcinoma (VSCC). In general reexcision is recommended when the minimum peripheral surgical margin (MPSM) is (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: ORIGINAL ARTICLES Source Type: research

Philip B. Clement, M.D. Reflections on a Rewarding 50 Year Career in Gynecologic Pathology: An Interview With Robert H. Young
No abstract available (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - August 19, 2020 Category: Pathology Tags: HISTORY OF GYNECOLOGICAL PATHOLOGY Source Type: research

Update on the ISGyP Endocervical Adenocarcinoma Project
No abstract available (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: Society page Source Type: research

A Case of Recurrent Vulvar Carcinoma With Cardiac Metastasis: Case Report and Review of the Literature
A 67-yr-old female patient was diagnosed with squamous cell vulvar carcinoma and treated with a radical vulvectomy and bilateral sentinel lymphadenectomy. Three months after the surgery, the patient presented with local recurrence and underwent surgical excision of the mass, followed by chemotherapy. Eight months later, the patient was admitted due to weakness and pleural effusion. The patient underwent a chest computed tomography and echocardiogram, which revealed a large mass in the right ventricle penetrating into the pericardium and an additional mass residing on the tricuspid valve. She underwent a pericardial biopsy,...
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: CASE REPORT Source Type: research

HPV-independent Vulvar Squamous Cell Carcinoma is Associated With Significantly Worse Prognosis Compared With HPV-associated Tumors
In conclusion, a subset of VSCC is associated with HPV, which correlates with better outcome. Relatively inexpensive tests such as histomorphologic evaluation, p16 immunohistochemistry, and HPV RNA ISH can be used to predict outcome in VSCC. Therefore, routine reporting of HPV status in VSCC is recommended. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: ORIGINAL ARTICLES Source Type: research

Correlation Between p16/Ki-67 Expression and the Grade of Cervical Intraepithelial Neoplasias
Interpretation of histopathology of cervical premalignant lesions suffers from marked interobserver variability due to its subjective nature. We aimed to evaluate the usefulness of the biomarkers p16 and Ki-67 in improving the diagnostic accuracy of cervical histopathology and assess the correlation between p16 expression and human papillomavirus test in different grades of cervical intraepithelial neoplasia (CIN). Cervical tissue specimens with a diagnosis of CIN 1 or worse (CIN 1+) on hematoxylin and eosin staining were selected for immunohistochemistry (IHC) staining for p16 and Ki-67. The IHC slides were examined by a ...
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: ORIGINAL ARTICLES Source Type: research

White Adipocytes of the Uterine Cervix Tend to Appear in Women of Older Age, Postmenopause Status, and Higher Body Mass Index
The human uterine cervix consists mainly of epithelium and stroma, including smooth muscle cells and fibrovascular tissues. Fat cells in the uterine cervix have been rarely reported, and the only previous research article has shown that intracervical adipocytes are unrelated to clinical factors. The aim of this study was to investigate the frequency of fat cells in the uterine cervix, as well as to evaluate the relationship between intracervical adipocytes and clinicopathologic factors. We retrospectively selected 405 cases in Japanese women who received cervical conization at our hospital between 2003 and 2017. Cervical c...
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: PATHOLOGY OF THE LOWER TRACT: ORIGINAL ARTICLES Source Type: research

Synchronous Well-differentiated Endometrioid Adenocarcinoma and Leiomyosarcoma of the Uterus With Pulmonary Metastasis in a 50-Yr-Old Woman: A Case Report and Review of Literature
We report the case of a 50-yr-old woman who was diagnosed with concomitant endometrial adenocarcinoma and uterine leiomyosarcoma. The sarcomatous neoplasm was positive for anti-smooth muscle actin and CD10, and focally positive for Cytokeratin AE1/AE3 and Cytokeratin Cam 5.2. She underwent total abdominal hysterectomy with bilateral salpingoopherectomy followed by radiation, brachytherapy, and chemotherapy. Three years later, she presented with cough and dyspnea and was found to have pulmonary metastasis. These tumor cells were positive for anti-smooth muscle actin, Cytokeratin AE1/AE3, Cytokeratin Cam 5.2, and epithelial ...
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORTS Source Type: research

Genetically Related Choriocarcinoma Developing 5 Yr After a Complete Hydatidiform Mole and Simulating a Cornual Ectopic Pregnancy
Persistent gestational trophoblastic disease can arise from any type of antecedent pregnancy, including molar and tubal pregnancies. While most cases of persistent gestational trophoblastic disease present within the first year following initial diagnosis, recurrence has rarely been reported many years after initial diagnosis. Distinguishing recurrence from a new independent lesion is clinically important. A 25-yr-old woman presented with a mass in the right uterine cornu that was discontiguous with the endometrial cavity and was associated with an elevated serum human chorionic gonadotropin level. She had a history of an ...
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORTS Source Type: research