International Journal of Gynecological Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Society
No abstract available (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Society Source Type: research

Androgen-induced Hyperplastic Prostatic Glands in the Uterine Cervix
No abstract available (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Online Article: Letter to the Editor Source Type: research

Vulvar Adenocarcinoma of Intestinal Type: A Case Report of an Uncommon Entity
We present a case of a 66-yr-old female who presented with vulvar pruritus and local discomfort, showing a 2 cm tumor located in the left labium minor in the region of vulvar fourchette. Wide vulvar excision and bilateral lymph nodes dissection were performed. Other concomitant lesions and distant extension of tumor were ruled out by positron emission tomography. Pathologic study revealed a colonic-type adenocarcinoma with typical villoglandular architecture with an irregular glandular structure composed of atypical columnar epithelium. The lesion had direct contact with epidermal surface and mainly was external without ...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Lower Tract: Case Report Source Type: research

Acinar Melanosis of the Bartholin Gland: A Report of 3 Cases
We report 3 patients with multiloculated cystic lesions of the vulvar vestibule exhibiting prominent melanocytic pigmentation. The current cases differ from a previous report of melanosis in a Bartholin gland cyst in that the population of melanocytes occupies the acinar structures of the gland, rather than a squamous-lined surface. A similar cell population is demonstrated by immunoperoxidase methods in a fourth patient’s nonpigmented gland, suggesting that melanin production may arise in a native, rather than metaplastic, cell population. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Lower Tract: Original Articles Source Type: research

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features
Basal cell carcinoma (BCC) is the most frequent skin cancer but (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Lower Tract: Original Articles Source Type: research

Primary Fallopian Tube Mullerian Adenosarcoma With Sarcomatous Overgrowth and a Previously Unreported MEIS1-NCOA2 Gene Fusion
We report a 55-yr-old patient seen in consultation for abdominal pain and bloating. Imaging was suggestive of a left adnexal mass and “peritoneal carcinomatosis”. Pathological examination of the specimen revealed a MA arising in the left fallopian tube, with sarcomatous overgrowth, diffuse peritoneal involvement and omental “caking”. Next-generation sequencing identified a MEIS1-NCOA2 gene fusion, previously unreported in MA. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Upper Tract: Case Report Source Type: research

Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series
We report a case series of 4 clear cell tumors (3 carcinomas, 1 borderline adenofibroma) coexisting in the same ovary with SMBT. In all cases, the SMBT was the predominant component and we highlight that adequate sampling of these tumors is important to detect small clear cell carcinomas, thus potentially altering the treatment and prognosis. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Upper Tract: Original Articles Source Type: research

Müllerian Mucinous Cystadenomas of the Ovary: A Report of 25 Cases of an Unheralded Benign Ovarian Neoplasm Often Associated With Endometriosis and a Brief Consideration of Neoplasms Arising From the Latter
A subset of ovarian mucinous tumors demonstrates müllerian-type epithelium, with such lesions variably designated “endocervical-like” and seromucinous since their popularization based on a report of borderline examples in 1989. While müllerian mucinous borderline tumors and carcinomas have been highlighted in the literature, there has been minimal attention given to benign müllerian mucinous tumors, particularly müllerian mucinous cystadenomas. Given the paucity of literature describing the features of müllerian mucinous cystadenomas/cystadenofibromas, diagnostic difficulties may arise when papillary features are ...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Upper Tract: Original Articles Source Type: research

Malignant Peritoneal Mesothelioma Associated With Endometriosis: A Clinicopathologic Study of 15 Cases
Only a few cases of malignant peritoneal mesothelioma (MPeM) associated with endometriosis have been published; with chronic inflammation of the peritoneum associated with the latter being postulated as an inducing factor in the pathogenesis of this tumor. We assessed the clinicopathologic characteristics of MPeM associated with endometriosis to determine if there were other factors besides inflammation that may contribute to the pathogenesis in this patient population. Fifteen MPeM associated with endometriosis were retrieved from our files. Most presented with abdominal/pelvic pain, mass or distention; median age was 45�...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Upper Tract: Original Articles Source Type: research

Placenta Teratoma or Acardiac Fetus Amorphous: A Case Study by DNA Genotyping
We present a case that would be compatible with placental teratoma according to these criteria. However, DNA genotyping analysis of the “teratoma” and its corresponding normal placental tissue revealed an identical genetic profile at all microsatellite polymorphic loci with exception of one locus demonstrating loss of heterozygosity involving 1 of 2 “teratoma” samples tested. Our finding established that the “teratoma” in fact represented a monozygotic acardiac (amorphous) twin with aberrant division of embryogenesis as a continuum of the monozygotic twinning phenomenon. In summary, this is the first case study...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research

Rare Complete Hydatidiform Mole With p57 Expression in Villous Mesenchyme: Case Report and Review of Discordant p57 Expression in Hydatidiform Moles
Complete hydatidiform mole (CHM) is a premalignant proliferative disease of the placenta characterized by misexpression of imprinted gene products, most notably p57. The majority of CHM exhibit immunohistochemical absence of p57 protein in villous mesenchyme (VM) and cytotrophoblast (CT) and are thus p57 VM/CT concordant. However, some gestations show loss of p57 in only VM or CT, either in all chorionic villi or a subset thereof (VM/CT discordant). Here, we present a rare case of a p57 VM/CT-discordant CHM with diffuse retention of p57 expression in VM but complete absence in CT. Histologically, the case exhibited typical...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research

Yolk Sac Tumor Arising in Uterine Carcinosarcoma With Endometrioid and Serous Components: A Case Report With Immunohistochemical Analysis
Yolk sac tumor of the endometrium is an uncommon neoplasm. Here we report a case of yolk sac tumor arising in a uterine carcinosarcoma, with the carcinomatous component showing both endometrioid and serous components, and the sarcomatous component showing homologous (spindled) differentiation. The yolk sac tumor showed predominant glandular configuration and was present admixed with the epithelial components. Extensive immunostaining was performed to narrow the differential diagnosis, including potentially therapeutic testing for HER-2. To our knowledge, this is the first case of carcinosarcoma with this mix of epithelial ...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research

Dedifferentiation in Breast Metastasis of Endometrial Carcinoma: A Diagnostic Dilemma
We report a case of dedifferentiation occurring in an isolated solitary breast metastasis of a low-grade endometrioid endometrial carcinoma. A 64-yr-old woman presented with a breast mass 2 yr after initial diagnosis of a grade 1 FIGO stage IIIA endometrioid endometrial carcinoma. Ultrasound guided biopsy of the breast mass showed a grade 1 endometrioid carcinoma which was diffusely estrogen receptor and PAX8-positive, consistent with metastasis from the previous endometrial carcinoma. The tumor initially responded to Letrozole therapy but then abruptly increased in size. Mastectomy revealed a poorly differentiated malig...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research

Androgen Receptor Immunohistochemical Expression in Undifferentiated/Dedifferentiated Endometrial Carcinoma
Uterine undifferentiated (UC)/dedifferentiated (DEAC) carcinomas are rare malignant neoplasms. They tend to pursue an aggressive clinical course with an advanced stage at presentation. It has been found that androgen receptor (AR) might play a role as a prognostic and therapeutic marker in endometrial carcinoma. However, its expression in UC/DEAC has not been investigated. Herein, the aim of this study was to evaluate the expression of AR along with estrogen receptor (ER), progestin receptor (PR), and HER2 in UC/DEAC and also in other subtypes of high-grade endometrial carcinomas. Review of our pathology database over the ...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Corpus: Original Articles Source Type: research

Concise Reporting of Benign Endometrial Biopsies is an Acceptable Alternative to Descriptive Reporting
In the United Kingdom, endometrial biopsy reports traditionally consist of a morphologic description followed by a conclusion. Recently published consensus guidelines for reporting benign endometrial biopsies advocate the use of standardized terminology. In this project we aimed to assess the acceptability and benefits of this simplified “diagnosis only” format for reporting non-neoplastic endometrial biopsies. Two consultants reported consecutive endometrial biopsies using 1 of 3 possible formats: (i) diagnosis only, (ii) diagnosis plus an accompanying comment, and (iii) the traditional descriptive format. Service use...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Corpus: Original Articles Source Type: research