Immune Responses Mediated by Th17 Cells in Helicobacter pylori Infection
T helper 17 (Th17) cells are one of the CD4+ T-cell subsets which induce a variety of diseases by secreting IL-17 and other inflammatory factors. After Helicobacter pylori (Hp) infection, cytotoxin-associated gene A and urease subunit B regulate the number of Th17 cells via induction of cell differentiation by infected macrophages, activation of MyD88 and other pathways, and by driving chemokines, which upregulates the number of both Th17 cells and regulatory T cells (Tregs) and switches towards a Treg-type immune response. Meanwhile, Th17 cells also play important roles in the response to Hp infection, participating in th...
Source: Integrative Medicine International - July 8, 2016 Category: Complementary Medicine Source Type: research
Herbal Medicine-Induced Liver Injury in China
Herbal medicine (HM) has been widely used to prevent and treat diseases for thousands of years. However, recent increasing evidence shows that HM-induced liver injury (HILI) is not something to be ignored. In fact, herbal toxicity has always been recognized and emphasized in the long history of Traditional Chinese Medicine. In this article, we analyzed the situation of HILI in China and its risk factors in detail. In addition, the legal regime of the HM industry in contemporary China is introduced. Recently, the mechanisms of HILI have been widely studied, and epidemiological investigations into HILI have been conducted. I...
Source: Integrative Medicine International - May 13, 2016 Category: Complementary Medicine Source Type: research
Targeting ONOO-/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment
Stroke is the leading cause of death and disability worldwide, and ischemic stroke accounts for more than 85% of the stroke incidence. Tissue plasminogen activator (t-PA) is the only FDA-approved drug for ischemic stroke treatment with a narrow treatment time window of 4.5 h. Hemorrhagic transformation (HT) is a severe complication of delayed t-PA treatment in ischemic stroke. Thus, it is critically important to develop combination therapies to reduce HT and extend the therapeutic time window of t-PA. Current progress suggests that peroxynitrite (ONOO-)/high-mobility group box 1 protein (HMGB1)/matrix metalloproteinase-9 (...
Source: Integrative Medicine International - February 3, 2016 Category: Complementary Medicine Source Type: research
SCN's 1st Annual Congress of Neuroendocrinology, Neuroimmunology and Chinese Integrative Medicine, and Gongji Stroke Forum. Shanghai General Hospital. Shanghai, China, November 19-20, 2015: Abstracts
Integr Med Int 2016;3:24-31 (Source: Integrative Medicine International)
Source: Integrative Medicine International - January 20, 2016 Category: Complementary Medicine Source Type: research
Evaluation of the Antiulcer Activity of the Leaves of Azadirachta indica: An Experimental Study
Conclusion: The leaves of A. indica possess significant antiulcer activity and act via multiple mechanisms.Integr Med Int 2016;3:10-16 (Source: Integrative Medicine International)
Source: Integrative Medicine International - January 15, 2016 Category: Complementary Medicine Source Type: research
Application of Laser Phoresis in Complicated Postmenopausal Osteoporosis
This study presents postmenopausal osteoporosis as a feature of metabolic systemic diseases of the skeleton, with abnormalities of the bone microarchitecture and reduction in bone mineral density, leading to an increased risk of fractures with a low level of trauma. The neurological manifestations of such fractures are uncharacteristic, representing a differential diagnostic indication. There is a change of posture in the form of hyperkyphosis of the thoracic spine and loss of height due to the increase in the number of modified vertebrae. The age of these patients is between 66 and 68 years, which limits the use of tradit...
Source: Integrative Medicine International - January 15, 2016 Category: Complementary Medicine Source Type: research
China's Tu Youyou, Nobel Laureate in Medicine 2015, and Relationships with the TCM Research Center Graz at the Medical University
For the first time in history, the Nobel Prize in Medicine 2015 was awarded to a researcher who is specialized in traditional Chinese medicine. The Chinese Tu Youyou received this highest award in medicine for her excellent work in malaria research. Tu Youyou and her team found out that artemisinin, the active ingredient of the medicinal herb ‘sweet wormwood', represents an effective malaria therapy. In the following article, the research that led to this Nobel Prize is introduced. In addition, the insidious tropical disease malaria will be explained briefly. Results of the research on moxibustion using Artemisia are als...
Source: Integrative Medicine International - December 11, 2015 Category: Complementary Medicine Source Type: research
Principles of Differentiation and Prescription for Vitiligo in Traditional Chinese Medicine Based on a Literature Investigation
Conclusion: The most frequent syndromes of vitiligo are liver and kidney deficiency, Qi stagnation and blood stasis. Most TCM doctors prefer prescribing herbs with efficacy in tonifying the liver and kidney, activating blood and expelling wind in treating vitiligo.Integr Med Int 2015;2:149-156 (Source: Integrative Medicine International)
Source: Integrative Medicine International - December 3, 2015 Category: Complementary Medicine Source Type: research
The Molecular Mechanism of Diastolic Heart Failure
Diastolic heart failure (DHF) is a group of clinical syndromes related to the performance of the pulmonary circulation and systemic circulation, with normal left ventricular (LV) systolic function. The pathophysiology of diastolic dysfunction includes delayed relaxation, impaired LV filling, and/or increased stiffness. These conditions result in impaired LV diastolic relaxation ability and a decrease in myocardial compliance. In recent years, studies on the mechanisms of DHF have focused on the renin-angiotensin-aldosterone system, inflammatory cytokines, oxidative stress, the process of myocardial calcium cycling, and ass...
Source: Integrative Medicine International - October 15, 2015 Category: Complementary Medicine Source Type: research
Integrative Medicine, the Direction of Future Medicine: An Interview with Prof. Wenjian Wang
Integr Med Int 2015;2:139-142 (Source: Integrative Medicine International)
Source: Integrative Medicine International - October 15, 2015 Category: Complementary Medicine Source Type: research
The Impact of School Environment on Children's Respiratory Health
Conclusions: The school environment had a direct impact on the respiratory health of children, with several factors having a direct impact on the children's health.Integr Med Int 2015;2:129-138 (Source: Integrative Medicine International)
Source: Integrative Medicine International - October 13, 2015 Category: Complementary Medicine Source Type: research
BIT's 2nd Annual World Congress of High-Tech Acupuncture and Integrative Medicine Hangzhou, May 2015: Abstracts
Integr Med Int 2015;2:90-128 (Source: Integrative Medicine International)
Source: Integrative Medicine International - October 13, 2015 Category: Complementary Medicine Source Type: research
A Practical Consensus Guideline for the Integrative Treatment of Parkinson's Disease in Shanghai, China
Integrative medicine, including traditional Chinese medicine (TCM), is a new concept in clinical practice for the treatment of neurodegenerative and most chronic diseases. However, integrative consensus or a guideline for the management of patients with Parkinson's disease (PD) is still lacking. The aim of this paper is to provide a review of experiences in clinical practice from Chinese neurologists and physicians (including TCM doctors) in Shanghai, China, and try to provide a clinical guideline for the treatment of the complex and progressive disease of PD with integrative medicine. We included the following treatments:...
Source: Integrative Medicine International - September 16, 2015 Category: Complementary Medicine Source Type: research
Amyloid Beta Peptide 1-42 Induces SH-SY5Y Cell Apoptosis via the Promotion of Meg3 Long Noncoding RNA Expression
Conclusion: Meg3 lncRNA is implicated as an important factor in the formation of mature Aβ peptides.Integr Med Int 2015;2:73-79 (Source: Integrative Medicine International)
Source: Integrative Medicine International - September 11, 2015 Category: Complementary Medicine Source Type: research
Transcranial Yellow, Red, and Infrared Laser and LED Stimulation: Changes of Vascular Parameters in a Chick Embryo Model
Conclusion: After intensive basic research (e.g. CAM model), transcranial laser stimulation may open up new therapies for lifestyle-related diseases such as stroke, dementia, Alzheimer's or possibly Parkinson's disease.Integr Med Int 2015;2:80-89 (Source: Integrative Medicine International)
Source: Integrative Medicine International - September 11, 2015 Category: Complementary Medicine Source Type: research
