Measurement of Blood Volume in Patients with Heart Failure: Clinical Relevance, Surrogates, Historical Background and Contemporary Methodology
Heart Int. 2023 May 11;17(1):36-43. doi: 10.17925/HI.2023.17.1.36. eCollection 2023.ABSTRACTThe development of clinical congestion resulting from volume overload, either by renal fluid retention or redistribution of blood volume from venous reservoirs, is a recurrent scenario in patients with chronic heart failure (HF). As a result, the treatment of congestion, most commonly by initiating aggressive diuretic therapy, is a front-line issue in the management of patients with HF. However, the association of clinical congestion and volume overload with physical signs and symptoms, as well as other surrogates of volume assessme...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Wayne L Miller Source Type: research
Outcomes of Prediabetes Compared with Normoglycaemia and Diabetes Mellitus in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis
Conclusion: Among patients who underwent PCI for CAD, the risk of all-cause and cardiac mortality, major adverse cardiovascular events and MI in prediabetic patients was higher compared with normoglycaemic patients but lower compared with patients with DM.PMID:37456347 | PMC:PMC10339437 | DOI:10.17925/HI.2023.17.1.45 (Source: Heart International)
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Muhammad Junaid Ahsan Azka Latif Soban Ahmad Claire Willman Noman Lateef Muhammad Asim Shabbir Mohammad Zoraiz Ahsan Amman Yousaf Maria Riasat Magdi Ghali Jolanta Siller-Matula Yeongjin Gwon Mamas A Mamas Emmanouil S Brilakis J Dawn Abbott Deepak L Bhatt Source Type: research
Peri- and Post-procedural Anticoagulation with Left Atrial Appendage Occlusion Devices
Heart Int. 2023 Jun 21;17(1):54-59. doi: 10.17925/HI.2023.17.1.54. eCollection 2023.ABSTRACTIn patients with atrial fibrillation and high stroke risk, anticoagulation with direct oral anticoagulants or vitamin K antagonists is the standard of care for stroke prevention. The benefit of anticoagulation is driven by attenuating the risk of thrombus formation in the left atrial appendage. Percutaneous left atrial appendage occlusion offers an alternative therapeutic strategy for stroke prevention in patients with high bleeding risk or contraindications for long-term anticoagulation. This review of the current literature deline...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Pradyumna Agasthi Sai Harika Pujari Source Type: research
Patisiran for the Treatment of Transthyretin-mediated Amyloidosis with Cardiomyopathy
Heart Int. 2023 Jun 8;17(1):27-35. doi: 10.17925/HI.2023.17.1.27. eCollection 2023.ABSTRACTTransthyretin (TTR) is a tetrameric protein, synthesized primarily by the liver, that acts as a physiological transport protein for retinol and thyroxine. TTR can misfold into pathogenic amyloid fibrils that deposit in the heart and nerves, causing a life-threatening transthyretin amyloidosis cardiomyopathy (ATTR-CM), and a progressive and debilitating polyneuropathy (ATTR-PN). Recent therapeutic advances have resulted in the development of drugs that reduce TTR production. Patisiran is a small interfering RNA that disrupts the compl...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Adam Ioannou Marianna Fontana Julian D Gillmore Source Type: research
Integrating Palliative Care into the Management of Heart Failure with Reduced Ejection Fraction: A Practice Pearl
Heart Int. 2023 Jun 13;17(1):5-7. doi: 10.17925/HI.2023.17.1.5. eCollection 2023.ABSTRACTHeart failure with reduced ejection fraction is a progressive, undulating syndrome with an unpredictable illness course featuring intermittent symptom exacerbations and periods of stability. The progressive, variable trajectory of the illness burdens patients with myriad threats to physical, emotional, and spiritual functioning, quality of life and complex treatment decisions. Integrating palliative care is a recommended best practice for heart failure management; however, confusion persists about what palliative care comprises in the ...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Abigail Latimer Christopher E Knoepke Roger Winters Source Type: research
Mavacamten, an Alternative to Septal Reduction Therapy for Patients with Hypertrophic Cardiomyopathy
Heart Int. 2023 Jun 13;17(1):2-4. doi: 10.17925/HI.2023.17.1.2. eCollection 2023.ABSTRACTHypertrophic cardiomyopathy (HCM) is a common heridetary cardiac disorder characterized by a wide range of symptoms. The pharmacological treatment of HCM is currently limited to beta blockers, non-dihydropyridine calcium channel blockers and disopyramide. Mavacamten is a novel cardiac myosin inhibitor, which was recently added to the limited pharmacological list of treatment options for HCM. This editorial elaborates on current evidence evaluating the use of mavacamten in patients with symptomatic obstructive HCM, comments on its curre...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Milind Y Desai Adel Hajj Ali Source Type: research
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock and Hyperkalaemia Syndrome Involving Digoxin Toxicity: A Case Report
Heart Int. 2023 Jun 8;17(1):60-62. doi: 10.17925/HI.2023.17.1.60. eCollection 2023.ABSTRACTBradycardia, renal failure, atrioventricular nodal blockade, shock and hyperkalemia (BRASH) syndrome is named after the pentad of symptoms experienced by patients with this clinical entity, and is propagated via a synergistic mechanism. Herein, we describe a case of an 81-year-old male who presented with bradycardia, dyspnoea on exertion, and confusion. He was also initially found to be in cardiogenic shock. In a setting of elevated digoxin levels, acute renal failure and hyperkalemia, he was diagnosed with BRASH syndrome. Prompt int...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Meet Shah Arthi Palani Ashkan Hashemi Jaewook Shin Source Type: research
Transcatheter Mitral Valve Replacement in Patients with Mitral Annular Calcification: A Review
Heart Int. 2023 Mar 29;17(1):19-26. doi: 10.17925/HI.2023.17.1.19. eCollection 2023.ABSTRACTMitral annular calcification (MAC) is a progressive degenerative calcification of the mitral valve (MV) that is associated with mitral stenosis, regurgitation or both. Patients with MAC are poor candidates for MV surgery because of technical challenges and high peri-operative mortality. Transcatheter MV replacement (TMVR) has emerged as an option for such high surgical risk patients. This has been described with the use of the SAPIEN transcatheter heart valve (valve-in-MAC) and dedicated TMVR devices. Careful anatomic assessment is ...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Ankit Agrawal Michael J Reardon Sachin S Goel Source Type: research
Balloon Aortic Valvuloplasty in the Transcatheter Aortic Valve Implantation Era
Heart Int. 2023 Jun 22;17(1):13-18. doi: 10.17925/HI.2023.17.1.13. eCollection 2023.ABSTRACTAs the population continues to grow, and life expectancy has increased, aortic stenosis (AS) has become the most common valvular disease requiring surgical treatment. The evolution of valve replacement therapies has progressed significantly since 1960. In the last 20 years, transcatheter aortic valve implantation (TAVI) has been a game changer, and has potential to become the standard of care. Despite uncertain prognosis benefits, balloon aortic valvuloplasty (BAV) can be useful in a broad range of patients with AS, as well as being...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Gustavo Arturo Samaja Source Type: research
Low-flow, Low-gradient Severe Aortic Stenosis: A Review
Heart Int. 2023 Jan 17;17(1):8-12. doi: 10.17925/HI.2023.17.1.8. eCollection 2023.ABSTRACTAortic stenosis (AS) is a common valve pathology experienced by patients worldwide. There are limited population-based studies assessing its prevalence; however, epidemiological studies emphasize that the burden of disease is growing. Recognizing AS relies on accurate clinical assessment and diagnostic investigations. Patients who develop severe AS are often referred to the heart team for assessment of aortic valve intervention. Although echocardiography has traditionally been used to screen and monitor the progression of AS, there ca...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Nishant Sharma Ayaaz K Sachedina Sachin Kumar Source Type: research
Measurement of Blood Volume in Patients with Heart Failure: Clinical Relevance, Surrogates, Historical Background and Contemporary Methodology
Heart Int. 2023 May 11;17(1):36-43. doi: 10.17925/HI.2023.17.1.36. eCollection 2023.ABSTRACTThe development of clinical congestion resulting from volume overload, either by renal fluid retention or redistribution of blood volume from venous reservoirs, is a recurrent scenario in patients with chronic heart failure (HF). As a result, the treatment of congestion, most commonly by initiating aggressive diuretic therapy, is a front-line issue in the management of patients with HF. However, the association of clinical congestion and volume overload with physical signs and symptoms, as well as other surrogates of volume assessme...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Wayne L Miller Source Type: research
Outcomes of Prediabetes Compared with Normoglycaemia and Diabetes Mellitus in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis
Conclusion: Among patients who underwent PCI for CAD, the risk of all-cause and cardiac mortality, major adverse cardiovascular events and MI in prediabetic patients was higher compared with normoglycaemic patients but lower compared with patients with DM.PMID:37456347 | PMC:PMC10339437 | DOI:10.17925/HI.2023.17.1.45 (Source: Heart International)
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Muhammad Junaid Ahsan Azka Latif Soban Ahmad Claire Willman Noman Lateef Muhammad Asim Shabbir Mohammad Zoraiz Ahsan Amman Yousaf Maria Riasat Magdi Ghali Jolanta Siller-Matula Yeongjin Gwon Mamas A Mamas Emmanouil S Brilakis J Dawn Abbott Deepak L Bhatt Source Type: research
Peri- and Post-procedural Anticoagulation with Left Atrial Appendage Occlusion Devices
Heart Int. 2023 Jun 21;17(1):54-59. doi: 10.17925/HI.2023.17.1.54. eCollection 2023.ABSTRACTIn patients with atrial fibrillation and high stroke risk, anticoagulation with direct oral anticoagulants or vitamin K antagonists is the standard of care for stroke prevention. The benefit of anticoagulation is driven by attenuating the risk of thrombus formation in the left atrial appendage. Percutaneous left atrial appendage occlusion offers an alternative therapeutic strategy for stroke prevention in patients with high bleeding risk or contraindications for long-term anticoagulation. This review of the current literature deline...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Pradyumna Agasthi Sai Harika Pujari Source Type: research
Patisiran for the Treatment of Transthyretin-mediated Amyloidosis with Cardiomyopathy
Heart Int. 2023 Jun 8;17(1):27-35. doi: 10.17925/HI.2023.17.1.27. eCollection 2023.ABSTRACTTransthyretin (TTR) is a tetrameric protein, synthesized primarily by the liver, that acts as a physiological transport protein for retinol and thyroxine. TTR can misfold into pathogenic amyloid fibrils that deposit in the heart and nerves, causing a life-threatening transthyretin amyloidosis cardiomyopathy (ATTR-CM), and a progressive and debilitating polyneuropathy (ATTR-PN). Recent therapeutic advances have resulted in the development of drugs that reduce TTR production. Patisiran is a small interfering RNA that disrupts the compl...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Adam Ioannou Marianna Fontana Julian D Gillmore Source Type: research
Integrating Palliative Care into the Management of Heart Failure with Reduced Ejection Fraction: A Practice Pearl
Heart Int. 2023 Jun 13;17(1):5-7. doi: 10.17925/HI.2023.17.1.5. eCollection 2023.ABSTRACTHeart failure with reduced ejection fraction is a progressive, undulating syndrome with an unpredictable illness course featuring intermittent symptom exacerbations and periods of stability. The progressive, variable trajectory of the illness burdens patients with myriad threats to physical, emotional, and spiritual functioning, quality of life and complex treatment decisions. Integrating palliative care is a recommended best practice for heart failure management; however, confusion persists about what palliative care comprises in the ...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Abigail Latimer Christopher E Knoepke Roger Winters Source Type: research
