Mavacamten, an Alternative to Septal Reduction Therapy for Patients with Hypertrophic Cardiomyopathy
Heart Int. 2023 Jun 13;17(1):2-4. doi: 10.17925/HI.2023.17.1.2. eCollection 2023.ABSTRACTHypertrophic cardiomyopathy (HCM) is a common heridetary cardiac disorder characterized by a wide range of symptoms. The pharmacological treatment of HCM is currently limited to beta blockers, non-dihydropyridine calcium channel blockers and disopyramide. Mavacamten is a novel cardiac myosin inhibitor, which was recently added to the limited pharmacological list of treatment options for HCM. This editorial elaborates on current evidence evaluating the use of mavacamten in patients with symptomatic obstructive HCM, comments on its curre...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Milind Y Desai Adel Hajj Ali Source Type: research
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock and Hyperkalaemia Syndrome Involving Digoxin Toxicity: A Case Report
Heart Int. 2023 Jun 8;17(1):60-62. doi: 10.17925/HI.2023.17.1.60. eCollection 2023.ABSTRACTBradycardia, renal failure, atrioventricular nodal blockade, shock and hyperkalemia (BRASH) syndrome is named after the pentad of symptoms experienced by patients with this clinical entity, and is propagated via a synergistic mechanism. Herein, we describe a case of an 81-year-old male who presented with bradycardia, dyspnoea on exertion, and confusion. He was also initially found to be in cardiogenic shock. In a setting of elevated digoxin levels, acute renal failure and hyperkalemia, he was diagnosed with BRASH syndrome. Prompt int...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Meet Shah Arthi Palani Ashkan Hashemi Jaewook Shin Source Type: research
Transcatheter Mitral Valve Replacement in Patients with Mitral Annular Calcification: A Review
Heart Int. 2023 Mar 29;17(1):19-26. doi: 10.17925/HI.2023.17.1.19. eCollection 2023.ABSTRACTMitral annular calcification (MAC) is a progressive degenerative calcification of the mitral valve (MV) that is associated with mitral stenosis, regurgitation or both. Patients with MAC are poor candidates for MV surgery because of technical challenges and high peri-operative mortality. Transcatheter MV replacement (TMVR) has emerged as an option for such high surgical risk patients. This has been described with the use of the SAPIEN transcatheter heart valve (valve-in-MAC) and dedicated TMVR devices. Careful anatomic assessment is ...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Ankit Agrawal Michael J Reardon Sachin S Goel Source Type: research
Balloon Aortic Valvuloplasty in the Transcatheter Aortic Valve Implantation Era
Heart Int. 2023 Jun 22;17(1):13-18. doi: 10.17925/HI.2023.17.1.13. eCollection 2023.ABSTRACTAs the population continues to grow, and life expectancy has increased, aortic stenosis (AS) has become the most common valvular disease requiring surgical treatment. The evolution of valve replacement therapies has progressed significantly since 1960. In the last 20 years, transcatheter aortic valve implantation (TAVI) has been a game changer, and has potential to become the standard of care. Despite uncertain prognosis benefits, balloon aortic valvuloplasty (BAV) can be useful in a broad range of patients with AS, as well as being...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Gustavo Arturo Samaja Source Type: research
Low-flow, Low-gradient Severe Aortic Stenosis: A Review
Heart Int. 2023 Jan 17;17(1):8-12. doi: 10.17925/HI.2023.17.1.8. eCollection 2023.ABSTRACTAortic stenosis (AS) is a common valve pathology experienced by patients worldwide. There are limited population-based studies assessing its prevalence; however, epidemiological studies emphasize that the burden of disease is growing. Recognizing AS relies on accurate clinical assessment and diagnostic investigations. Patients who develop severe AS are often referred to the heart team for assessment of aortic valve intervention. Although echocardiography has traditionally been used to screen and monitor the progression of AS, there ca...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Nishant Sharma Ayaaz K Sachedina Sachin Kumar Source Type: research
