Conduction System Pacing: Have We Finally Found the Holy Grail of Physiological Pacing?
Heart Int. 2023 Dec 1;17(2):2-5. doi: 10.17925/HI.2023.17.2.2. eCollection 2023.ABSTRACTThe late fifties are considered a high point in the history of cardiac pacing, since this era is marked by the first pacemaker implantation, which has since evolved into life-saving therapy. Right ventricular apical and biventricular pacing are the classic techniques that are recommended as first-l ine approaches for most indications in current guidelines. However, conduction system pacing has emerged as being able to deliver a more physiological form of pacing and is becoming mainstream practice in a growing number of centres. In this ...
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Myriam Kaddour Haran Burri Source Type: research
Assessment and Management of Ischaemic Heart Disease in Non-Cardiac Surgery
Heart Int. 2023 Dec 1;17(2):19-26. doi: 10.17925/HI.2023.17.2.19. eCollection 2023.ABSTRACTIn the setting of non-cardiac surgery, cardiac complications contribute to over a third of perioperative deaths. With over 230 million major surgeries performed annually, and an increasing prevalence of cardiovascular risk factors and ischaemic heart disease, the incidence of perioperative myocardial infarction is also rising. The recent European Society of Cardiology guidelines on cardiovascular risk in noncardiac surgery elevated practices aiming to identify those at most risk, including biomarker monitoring and stress testing. How...
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Holly Morgan Saad M Ezad Haseeb Rahman Kalpa De Silva Judith S L Partridge Divaka Perera Source Type: research
Sarcopenic Obesity as a Risk Factor for Cardiovascular Disease: An Underrecognized Clinical Entity
This article covers the available literature regarding the definition, diagnostic criteria, and prevalence of SO, with available evidence linking it to CVD, metabolic disease and mortality, and an overview of current directives on management.PMID:38419720 | PMC:PMC10897945 | DOI:10.17925/HI.2023.17.2.6 (Source: Heart International)
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Aditya John Binu Nitin Kapoor Saptarshi Bhattacharya Kamal Kishor Sanjay Kalra Source Type: research
Bempedoic Acid: Lipid Lowering for Cardiovascular Disease Prevention
Heart Int. 2023 Nov 1;17(2):27-34. doi: 10.17925/HI.2023.17.2.1. eCollection 2023.ABSTRACTThe management of low-density lipoprotein cholesterol (LDL-C) levels is a central strategy for the prevention of atherosclerotic cardiovascular disease. Current United States (2018 American Heart Association/American College of Cardiology/Multisociety) and European (2019 European Society of Cardiology/European Atherosclerosis Society) guidelines endorse statin therapy as the first-line therapy for pharmacologic LDL-C lowering. However, in clinical practice up to 30% of patients report partial or complete intolerance to statin therapy....
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Michael Albosta Jelani K Grant Erin D Michos Source Type: research
Sodium Glucose Co-Transporter 2 Inhibitors and the Cardiovascular System: Current Knowledge and Future Expectations
Heart Int. 2023 Dec 1;17(2):12-18. doi: 10.17925/HI.2023.17.2.12. eCollection 2023.ABSTRACTDiabetic cardiomyopathy is a well-recognized clinical entity and reflects a complex relationship between metabolic substrates and myocardial function. Sodium glucose co-transporter 2 (SGLT2) inhibitors are antidiabetic agents that are found to exert multiple cardioprotective effects. Large clinical trials showed their beneficial effects on patients with heart failure, reducing the rates of rehospitalizations and improving kidney function. The aim of this review is to summarize the latest evidence in the literature regarding the multi...
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Ioannis Boutsikos Eleftherios Beltsios Bastian Schmack Ioannis Pantazopoulos Dimitrios G Chatzis Source Type: research
Conduction System Pacing: Have We Finally Found the Holy Grail of Physiological Pacing?
Heart Int. 2023 Dec 1;17(2):2-5. doi: 10.17925/HI.2023.17.2.2. eCollection 2023.ABSTRACTThe late fifties are considered a high point in the history of cardiac pacing, since this era is marked by the first pacemaker implantation, which has since evolved into life-saving therapy. Right ventricular apical and biventricular pacing are the classic techniques that are recommended as first-l ine approaches for most indications in current guidelines. However, conduction system pacing has emerged as being able to deliver a more physiological form of pacing and is becoming mainstream practice in a growing number of centres. In this ...
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Myriam Kaddour Haran Burri Source Type: research
Assessment and Management of Ischaemic Heart Disease in Non-Cardiac Surgery
Heart Int. 2023 Dec 1;17(2):19-26. doi: 10.17925/HI.2023.17.2.19. eCollection 2023.ABSTRACTIn the setting of non-cardiac surgery, cardiac complications contribute to over a third of perioperative deaths. With over 230 million major surgeries performed annually, and an increasing prevalence of cardiovascular risk factors and ischaemic heart disease, the incidence of perioperative myocardial infarction is also rising. The recent European Society of Cardiology guidelines on cardiovascular risk in noncardiac surgery elevated practices aiming to identify those at most risk, including biomarker monitoring and stress testing. How...
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Holly Morgan Saad M Ezad Haseeb Rahman Kalpa De Silva Judith S L Partridge Divaka Perera Source Type: research
Sarcopenic Obesity as a Risk Factor for Cardiovascular Disease: An Underrecognized Clinical Entity
This article covers the available literature regarding the definition, diagnostic criteria, and prevalence of SO, with available evidence linking it to CVD, metabolic disease and mortality, and an overview of current directives on management.PMID:38419720 | PMC:PMC10897945 | DOI:10.17925/HI.2023.17.2.6 (Source: Heart International)
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Aditya John Binu Nitin Kapoor Saptarshi Bhattacharya Kamal Kishor Sanjay Kalra Source Type: research
Bempedoic Acid: Lipid Lowering for Cardiovascular Disease Prevention
Heart Int. 2023 Nov 1;17(2):27-34. doi: 10.17925/HI.2023.17.2.1. eCollection 2023.ABSTRACTThe management of low-density lipoprotein cholesterol (LDL-C) levels is a central strategy for the prevention of atherosclerotic cardiovascular disease. Current United States (2018 American Heart Association/American College of Cardiology/Multisociety) and European (2019 European Society of Cardiology/European Atherosclerosis Society) guidelines endorse statin therapy as the first-line therapy for pharmacologic LDL-C lowering. However, in clinical practice up to 30% of patients report partial or complete intolerance to statin therapy....
Source: Heart International - February 29, 2024 Category: Cardiology Authors: Michael Albosta Jelani K Grant Erin D Michos Source Type: research
Low-flow, Low-gradient Severe Aortic Stenosis: A Review
Heart Int. 2023 Jan 17;17(1):8-12. doi: 10.17925/HI.2023.17.1.8. eCollection 2023.ABSTRACTAortic stenosis (AS) is a common valve pathology experienced by patients worldwide. There are limited population-based studies assessing its prevalence; however, epidemiological studies emphasize that the burden of disease is growing. Recognizing AS relies on accurate clinical assessment and diagnostic investigations. Patients who develop severe AS are often referred to the heart team for assessment of aortic valve intervention. Although echocardiography has traditionally been used to screen and monitor the progression of AS, there ca...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Nishant Sharma Ayaaz K Sachedina Sachin Kumar Source Type: research
Measurement of Blood Volume in Patients with Heart Failure: Clinical Relevance, Surrogates, Historical Background and Contemporary Methodology
Heart Int. 2023 May 11;17(1):36-43. doi: 10.17925/HI.2023.17.1.36. eCollection 2023.ABSTRACTThe development of clinical congestion resulting from volume overload, either by renal fluid retention or redistribution of blood volume from venous reservoirs, is a recurrent scenario in patients with chronic heart failure (HF). As a result, the treatment of congestion, most commonly by initiating aggressive diuretic therapy, is a front-line issue in the management of patients with HF. However, the association of clinical congestion and volume overload with physical signs and symptoms, as well as other surrogates of volume assessme...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Wayne L Miller Source Type: research
Outcomes of Prediabetes Compared with Normoglycaemia and Diabetes Mellitus in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis
Conclusion: Among patients who underwent PCI for CAD, the risk of all-cause and cardiac mortality, major adverse cardiovascular events and MI in prediabetic patients was higher compared with normoglycaemic patients but lower compared with patients with DM.PMID:37456347 | PMC:PMC10339437 | DOI:10.17925/HI.2023.17.1.45 (Source: Heart International)
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Muhammad Junaid Ahsan Azka Latif Soban Ahmad Claire Willman Noman Lateef Muhammad Asim Shabbir Mohammad Zoraiz Ahsan Amman Yousaf Maria Riasat Magdi Ghali Jolanta Siller-Matula Yeongjin Gwon Mamas A Mamas Emmanouil S Brilakis J Dawn Abbott Deepak L Bhatt Source Type: research
Peri- and Post-procedural Anticoagulation with Left Atrial Appendage Occlusion Devices
Heart Int. 2023 Jun 21;17(1):54-59. doi: 10.17925/HI.2023.17.1.54. eCollection 2023.ABSTRACTIn patients with atrial fibrillation and high stroke risk, anticoagulation with direct oral anticoagulants or vitamin K antagonists is the standard of care for stroke prevention. The benefit of anticoagulation is driven by attenuating the risk of thrombus formation in the left atrial appendage. Percutaneous left atrial appendage occlusion offers an alternative therapeutic strategy for stroke prevention in patients with high bleeding risk or contraindications for long-term anticoagulation. This review of the current literature deline...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Pradyumna Agasthi Sai Harika Pujari Source Type: research
Patisiran for the Treatment of Transthyretin-mediated Amyloidosis with Cardiomyopathy
Heart Int. 2023 Jun 8;17(1):27-35. doi: 10.17925/HI.2023.17.1.27. eCollection 2023.ABSTRACTTransthyretin (TTR) is a tetrameric protein, synthesized primarily by the liver, that acts as a physiological transport protein for retinol and thyroxine. TTR can misfold into pathogenic amyloid fibrils that deposit in the heart and nerves, causing a life-threatening transthyretin amyloidosis cardiomyopathy (ATTR-CM), and a progressive and debilitating polyneuropathy (ATTR-PN). Recent therapeutic advances have resulted in the development of drugs that reduce TTR production. Patisiran is a small interfering RNA that disrupts the compl...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Adam Ioannou Marianna Fontana Julian D Gillmore Source Type: research
Integrating Palliative Care into the Management of Heart Failure with Reduced Ejection Fraction: A Practice Pearl
Heart Int. 2023 Jun 13;17(1):5-7. doi: 10.17925/HI.2023.17.1.5. eCollection 2023.ABSTRACTHeart failure with reduced ejection fraction is a progressive, undulating syndrome with an unpredictable illness course featuring intermittent symptom exacerbations and periods of stability. The progressive, variable trajectory of the illness burdens patients with myriad threats to physical, emotional, and spiritual functioning, quality of life and complex treatment decisions. Integrating palliative care is a recommended best practice for heart failure management; however, confusion persists about what palliative care comprises in the ...
Source: Heart International - July 17, 2023 Category: Cardiology Authors: Abigail Latimer Christopher E Knoepke Roger Winters Source Type: research
