Promising new pharmacological targets for depression: the search for efficacy
Drug Discov Today. 2023 Oct 19:103804. doi: 10.1016/j.drudis.2023.103804. Online ahead of print.ABSTRACTPharmacological treatment of major depressive disorder (MDD) still relies on the use of serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have been developed in recent years, but many fail in clinical trials. Several hypotheses have been proposed to explain MDD pathophysiology, indicating that physiological processes such as neuroplasticity, circadian rhythms, and metabolism are potential targets. Here, we review the current state of pharmacological treatments for MDD and their problems,...
Source: Drug Discovery Today - October 21, 2023 Category: Drugs & Pharmacology Authors: Lucila Emiko Tsugiyama Ruan Carlos Macedo Moraes Yaslle Andrade Cavalcante Moraes Jose Francis-Oliveira Source Type: research
Promising new pharmacological targets for depression: the search for efficacy
Drug Discov Today. 2023 Oct 19:103804. doi: 10.1016/j.drudis.2023.103804. Online ahead of print.ABSTRACTPharmacological treatment of major depressive disorder (MDD) still relies on the use of serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have been developed in recent years, but many fail in clinical trials. Several hypotheses have been proposed to explain MDD pathophysiology, indicating that physiological processes such as neuroplasticity, circadian rhythms, and metabolism are potential targets. Here, we review the current state of pharmacological treatments for MDD and their problems,...
Source: Drug Discovery Today - October 21, 2023 Category: Drugs & Pharmacology Authors: Lucila Emiko Tsugiyama Ruan Carlos Macedo Moraes Yaslle Andrade Cavalcante Moraes Jose Francis-Oliveira Source Type: research
Promising new pharmacological targets for depression: the search for efficacy
Drug Discov Today. 2023 Oct 19:103804. doi: 10.1016/j.drudis.2023.103804. Online ahead of print.ABSTRACTPharmacological treatment of major depressive disorder (MDD) still relies on the use of serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have been developed in recent years, but many fail in clinical trials. Several hypotheses have been proposed to explain MDD pathophysiology, indicating that physiological processes such as neuroplasticity, circadian rhythms, and metabolism are potential targets. Here, we review the current state of pharmacological treatments for MDD and their problems,...
Source: Drug Discovery Today - October 21, 2023 Category: Drugs & Pharmacology Authors: Lucila Emiko Tsugiyama Ruan Carlos Macedo Moraes Yaslle Andrade Cavalcante Moraes Jose Francis-Oliveira Source Type: research
Promising new pharmacological targets for depression: the search for efficacy
Drug Discov Today. 2023 Oct 19:103804. doi: 10.1016/j.drudis.2023.103804. Online ahead of print.ABSTRACTPharmacological treatment of major depressive disorder (MDD) still relies on the use of serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have been developed in recent years, but many fail in clinical trials. Several hypotheses have been proposed to explain MDD pathophysiology, indicating that physiological processes such as neuroplasticity, circadian rhythms, and metabolism are potential targets. Here, we review the current state of pharmacological treatments for MDD and their problems,...
Source: Drug Discovery Today - October 21, 2023 Category: Drugs & Pharmacology Authors: Lucila Emiko Tsugiyama Ruan Carlos Macedo Moraes Yaslle Andrade Cavalcante Moraes Jose Francis-Oliveira Source Type: research
Anti-amyloid potential of some phytochemicals against A β-peptide and α-synuclein, tau, prion, and Huntington proteins
Drug Discov Today. 2023 Oct 17:103802. doi: 10.1016/j.drudis.2023.103802. Online ahead of print.ABSTRACTSome molecules self-assemble to create complex structures through molecular self-assembly. Hydrogel preparation, tissue repair, and therapeutic drug delivery are a few applications of molecular self-assembly. However, the self-assembly of amino acids, peptides, and proteins forms amyloid fibrils, resulting in various disorders, most notably neurodegenerative ailments. Examples include the self-assembly of phenylalanine, which causes phenylketonuria; Aβ, which causes Alzheimer's disease; the tau protein, which causes bot...
Source: Drug Discovery Today - October 20, 2023 Category: Drugs & Pharmacology Authors: Jenat Pazheparambil Jerom Soorylekshmi Madhukumar Raveendran Harikumaran Nair Sunilkumar Puthenpurackal Narayanan Source Type: research
