General aspects of powder rheology applied to pharmaceutical formulations
Drug Discov Today. 2024 Apr 3:103976. doi: 10.1016/j.drudis.2024.103976. Online ahead of print.ABSTRACTPowder flowability is crucial in the pharmaceutical industry, strongly affecting solid dosage processing. Classical experimental techniques offer straightforward results for the rapid screening of formulations during development. However, they fail to describe powder properties under consolidation. Complex techniques, such as shear cell, accurately assess fundamental properties of particulate samples under realistic conditions, enabling prediction of their flow. Ideally, a combination of experimental methods should be use...
Source: Drug Discovery Today - April 5, 2024 Category: Drugs & Pharmacology Authors: Marcos Mariano Source Type: research
DDR1-targeted therapies: current limitations and future potential
Drug Discov Today. 2024 Apr 3:103975. doi: 10.1016/j.drudis.2024.103975. Online ahead of print.ABSTRACTDiscoidin domain receptor (DDR)-1 has a crucial role in regulating vital processes, including cell differentiation, proliferation, adhesion, migration, invasion, and matrix remodeling. Overexpression or activation of DDR1 in various pathological scenarios makes it a potential therapeutic target for the treatment of cancer, fibrosis, atherosclerosis, and neuropsychiatric, psychiatric, and neurodegenerative disorders. In this review, we summarize current therapeutic approaches targeting DDR1 from a medicinal chemistry persp...
Source: Drug Discovery Today - April 5, 2024 Category: Drugs & Pharmacology Authors: Donglin Wu Zihui Ding Tao Lu Yadong Chen Feng Zhang Shuai Lu Source Type: research
General aspects of powder rheology applied to pharmaceutical formulations
Drug Discov Today. 2024 Apr 3:103976. doi: 10.1016/j.drudis.2024.103976. Online ahead of print.ABSTRACTPowder flowability is crucial in the pharmaceutical industry, strongly affecting solid dosage processing. Classical experimental techniques offer straightforward results for the rapid screening of formulations during development. However, they fail to describe powder properties under consolidation. Complex techniques, such as shear cell, accurately assess fundamental properties of particulate samples under realistic conditions, enabling prediction of their flow. Ideally, a combination of experimental methods should be use...
Source: Drug Discovery Today - April 5, 2024 Category: Drugs & Pharmacology Authors: Marcos Mariano Source Type: research
DDR1-targeted therapies: current limitations and future potential
Drug Discov Today. 2024 Apr 3:103975. doi: 10.1016/j.drudis.2024.103975. Online ahead of print.ABSTRACTDiscoidin domain receptor (DDR)-1 has a crucial role in regulating vital processes, including cell differentiation, proliferation, adhesion, migration, invasion, and matrix remodeling. Overexpression or activation of DDR1 in various pathological scenarios makes it a potential therapeutic target for the treatment of cancer, fibrosis, atherosclerosis, and neuropsychiatric, psychiatric, and neurodegenerative disorders. In this review, we summarize current therapeutic approaches targeting DDR1 from a medicinal chemistry persp...
Source: Drug Discovery Today - April 5, 2024 Category: Drugs & Pharmacology Authors: Donglin Wu Zihui Ding Tao Lu Yadong Chen Feng Zhang Shuai Lu Source Type: research
General aspects of powder rheology applied to pharmaceutical formulations
Drug Discov Today. 2024 Apr 3:103976. doi: 10.1016/j.drudis.2024.103976. Online ahead of print.ABSTRACTPowder flowability is crucial in the pharmaceutical industry, strongly affecting solid dosage processing. Classical experimental techniques offer straightforward results for the rapid screening of formulations during development. However, they fail to describe powder properties under consolidation. Complex techniques, such as shear cell, accurately assess fundamental properties of particulate samples under realistic conditions, enabling prediction of their flow. Ideally, a combination of experimental methods should be use...
Source: Drug Discovery Today - April 5, 2024 Category: Drugs & Pharmacology Authors: Marcos Mariano Source Type: research
DDR1-targeted therapies: current limitations and future potential
Drug Discov Today. 2024 Apr 3:103975. doi: 10.1016/j.drudis.2024.103975. Online ahead of print.ABSTRACTDiscoidin domain receptor (DDR)-1 has a crucial role in regulating vital processes, including cell differentiation, proliferation, adhesion, migration, invasion, and matrix remodeling. Overexpression or activation of DDR1 in various pathological scenarios makes it a potential therapeutic target for the treatment of cancer, fibrosis, atherosclerosis, and neuropsychiatric, psychiatric, and neurodegenerative disorders. In this review, we summarize current therapeutic approaches targeting DDR1 from a medicinal chemistry persp...
Source: Drug Discovery Today - April 5, 2024 Category: Drugs & Pharmacology Authors: Donglin Wu Zihui Ding Tao Lu Yadong Chen Feng Zhang Shuai Lu Source Type: research
Immunotherapy: An emerging treatment option for neurodegenerative diseases
Drug Discov Today. 2024 Mar 28:103974. doi: 10.1016/j.drudis.2024.103974. Online ahead of print.ABSTRACTAccumulation of misfolded proteins and protein aggregates leading to degeneration of neurons is a hallmark of several neurodegenerative diseases. Therapy mostly relies on symptomatic relief. Immunotherapy offers a promising approach for the development of disease-modifying routes. Such strategies have shown remarkable results in oncology, and this promise is increasingly being realized for neurodegenerative diseases in advanced preclinical and clinical studies. This review highlights cases of passive and active immunothe...
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Abhiyanta Mukherjee Soumojit Biswas Ipsita Roy Source Type: research
The role of venom proteomics and single-domain antibodies for antivenoms: Progress in snake envenoming treatment
We present an overview of current antivenom therapy in the context of sdAb development for toxin neutralization. Furthermore, strategies are presented for identifying snake venom's major toxins as well as for developing antisnake toxin sdAbs by employing proteomic tools for toxin neutralization.PMID:38555033 | DOI:10.1016/j.drudis.2024.103967 (Source: Drug Discovery Today)
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Anna Carolina Machado Marinho Alexander Chapeaurouge Brunheld Maia Dutra Barbara Cibelle S F Quintela Soraya S Pereira Carla Freire C Fernandes Source Type: research
Immunotherapy: An emerging treatment option for neurodegenerative diseases
Drug Discov Today. 2024 Mar 28:103974. doi: 10.1016/j.drudis.2024.103974. Online ahead of print.ABSTRACTAccumulation of misfolded proteins and protein aggregates leading to degeneration of neurons is a hallmark of several neurodegenerative diseases. Therapy mostly relies on symptomatic relief. Immunotherapy offers a promising approach for the development of disease-modifying routes. Such strategies have shown remarkable results in oncology, and this promise is increasingly being realized for neurodegenerative diseases in advanced preclinical and clinical studies. This review highlights cases of passive and active immunothe...
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Abhiyanta Mukherjee Soumojit Biswas Ipsita Roy Source Type: research
The role of venom proteomics and single-domain antibodies for antivenoms: Progress in snake envenoming treatment
We present an overview of current antivenom therapy in the context of sdAb development for toxin neutralization. Furthermore, strategies are presented for identifying snake venom's major toxins as well as for developing antisnake toxin sdAbs by employing proteomic tools for toxin neutralization.PMID:38555033 | DOI:10.1016/j.drudis.2024.103967 (Source: Drug Discovery Today)
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Anna Carolina Machado Marinho Alexander Chapeaurouge Brunheld Maia Dutra Barbara Cibelle S F Quintela Soraya S Pereira Carla Freire C Fernandes Source Type: research
Immunotherapy: An emerging treatment option for neurodegenerative diseases
Drug Discov Today. 2024 Mar 28:103974. doi: 10.1016/j.drudis.2024.103974. Online ahead of print.ABSTRACTAccumulation of misfolded proteins and protein aggregates leading to degeneration of neurons is a hallmark of several neurodegenerative diseases. Therapy mostly relies on symptomatic relief. Immunotherapy offers a promising approach for the development of disease-modifying routes. Such strategies have shown remarkable results in oncology, and this promise is increasingly being realized for neurodegenerative diseases in advanced preclinical and clinical studies. This review highlights cases of passive and active immunothe...
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Abhiyanta Mukherjee Soumojit Biswas Ipsita Roy Source Type: research
The role of venom proteomics and single-domain antibodies for antivenoms: Progress in snake envenoming treatment
We present an overview of current antivenom therapy in the context of sdAb development for toxin neutralization. Furthermore, strategies are presented for identifying snake venom's major toxins as well as for developing antisnake toxin sdAbs by employing proteomic tools for toxin neutralization.PMID:38555033 | DOI:10.1016/j.drudis.2024.103967 (Source: Drug Discovery Today)
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Anna Carolina Machado Marinho Alexander Chapeaurouge Brunheld Maia Dutra Barbara Cibelle S F Quintela Soraya S Pereira Carla Freire C Fernandes Source Type: research
Immunotherapy: An emerging treatment option for neurodegenerative diseases
Drug Discov Today. 2024 Mar 28:103974. doi: 10.1016/j.drudis.2024.103974. Online ahead of print.ABSTRACTAccumulation of misfolded proteins and protein aggregates leading to degeneration of neurons is a hallmark of several neurodegenerative diseases. Therapy mostly relies on symptomatic relief. Immunotherapy offers a promising approach for the development of disease-modifying routes. Such strategies have shown remarkable results in oncology, and this promise is increasingly being realized for neurodegenerative diseases in advanced preclinical and clinical studies. This review highlights cases of passive and active immunothe...
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Abhiyanta Mukherjee Soumojit Biswas Ipsita Roy Source Type: research
The role of venom proteomics and single-domain antibodies for antivenoms: Progress in snake envenoming treatment
We present an overview of current antivenom therapy in the context of sdAb development for toxin neutralization. Furthermore, strategies are presented for identifying snake venom's major toxins as well as for developing antisnake toxin sdAbs by employing proteomic tools for toxin neutralization.PMID:38555033 | DOI:10.1016/j.drudis.2024.103967 (Source: Drug Discovery Today)
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Anna Carolina Machado Marinho Alexander Chapeaurouge Brunheld Maia Dutra Barbara Cibelle S F Quintela Soraya S Pereira Carla Freire C Fernandes Source Type: research
Immunotherapy: An emerging treatment option for neurodegenerative diseases
Drug Discov Today. 2024 Mar 28:103974. doi: 10.1016/j.drudis.2024.103974. Online ahead of print.ABSTRACTAccumulation of misfolded proteins and protein aggregates leading to degeneration of neurons is a hallmark of several neurodegenerative diseases. Therapy mostly relies on symptomatic relief. Immunotherapy offers a promising approach for the development of disease-modifying routes. Such strategies have shown remarkable results in oncology, and this promise is increasingly being realized for neurodegenerative diseases in advanced preclinical and clinical studies. This review highlights cases of passive and active immunothe...
Source: Drug Discovery Today - March 30, 2024 Category: Drugs & Pharmacology Authors: Abhiyanta Mukherjee Soumojit Biswas Ipsita Roy Source Type: research
