Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: lessons for precision medicine
CONCLUSIONS: This study reveals diverse clinical presentations among the carriers of a P/LP PDX1 variant, highlighting strong variations in diabetes onset, and unexpectedly high prevalence of obesity and pancreatic development abnormalities. Clinical data suggest that DPP4i and GLP1-RA may be the best effective treatments to manage both glucose and weight controls, opening new avenue in precision diabetic medicine.PMID:38141807 | DOI:10.1016/j.diabet.2023.101507 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Youssef Kouidrat Lauriane Le Collen Martine Vaxillaire Aur élie Dechaume B énédicte Toussaint Emmanuel Vaillant Souhila Amanzougarene Mehdi Derhourhi Brigitte Delemer Mustapha Azahaf Philippe Froguel Am élie Bonnefond Source Type: research
Steatotic liver disease, MASLD and risk of chronic kidney disease
Diabetes Metab. 2023 Dec 21:101506. doi: 10.1016/j.diabet.2023.101506. Online ahead of print.ABSTRACTWith the rising tide of fatty liver disease related to metabolic dysfunction worldwide, the association of this common liver disease with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the old term nonalcoholic fatty liver disease (NAFLD). In 2023, a modified Delphi process was led by three large pan-national liver associations. There was consensus to change the fatty liver disease nomenclatur...
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Josh Bilson Alessandro Mantovani Christopher D Byrne Giovanni Targher Source Type: research
Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: lessons for precision medicine
CONCLUSIONS: This study reveals diverse clinical presentations among the carriers of a P/LP PDX1 variant, highlighting strong variations in diabetes onset, and unexpectedly high prevalence of obesity and pancreatic development abnormalities. Clinical data suggest that DPP4i and GLP1-RA may be the best effective treatments to manage both glucose and weight controls, opening new avenue in precision diabetic medicine.PMID:38141807 | DOI:10.1016/j.diabet.2023.101507 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Youssef Kouidrat Lauriane Le Collen Martine Vaxillaire Aur élie Dechaume B énédicte Toussaint Emmanuel Vaillant Souhila Amanzougarene Mehdi Derhourhi Brigitte Delemer Mustapha Azahaf Philippe Froguel Am élie Bonnefond Source Type: research
Steatotic liver disease, MASLD and risk of chronic kidney disease
Diabetes Metab. 2023 Dec 21:101506. doi: 10.1016/j.diabet.2023.101506. Online ahead of print.ABSTRACTWith the rising tide of fatty liver disease related to metabolic dysfunction worldwide, the association of this common liver disease with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the old term nonalcoholic fatty liver disease (NAFLD). In 2023, a modified Delphi process was led by three large pan-national liver associations. There was consensus to change the fatty liver disease nomenclatur...
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Josh Bilson Alessandro Mantovani Christopher D Byrne Giovanni Targher Source Type: research
Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: lessons for precision medicine
CONCLUSIONS: This study reveals diverse clinical presentations among the carriers of a P/LP PDX1 variant, highlighting strong variations in diabetes onset, and unexpectedly high prevalence of obesity and pancreatic development abnormalities. Clinical data suggest that DPP4i and GLP1-RA may be the best effective treatments to manage both glucose and weight controls, opening new avenue in precision diabetic medicine.PMID:38141807 | DOI:10.1016/j.diabet.2023.101507 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Youssef Kouidrat Lauriane Le Collen Martine Vaxillaire Aur élie Dechaume B énédicte Toussaint Emmanuel Vaillant Souhila Amanzougarene Mehdi Derhourhi Brigitte Delemer Mustapha Azahaf Philippe Froguel Am élie Bonnefond Source Type: research
Steatotic liver disease, MASLD and risk of chronic kidney disease
Diabetes Metab. 2023 Dec 21:101506. doi: 10.1016/j.diabet.2023.101506. Online ahead of print.ABSTRACTWith the rising tide of fatty liver disease related to metabolic dysfunction worldwide, the association of this common liver disease with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the old term nonalcoholic fatty liver disease (NAFLD). In 2023, a modified Delphi process was led by three large pan-national liver associations. There was consensus to change the fatty liver disease nomenclatur...
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Josh Bilson Alessandro Mantovani Christopher D Byrne Giovanni Targher Source Type: research
Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: lessons for precision medicine
CONCLUSIONS: This study reveals diverse clinical presentations among the carriers of a P/LP PDX1 variant, highlighting strong variations in diabetes onset, and unexpectedly high prevalence of obesity and pancreatic development abnormalities. Clinical data suggest that DPP4i and GLP1-RA may be the best effective treatments to manage both glucose and weight controls, opening new avenue in precision diabetic medicine.PMID:38141807 | DOI:10.1016/j.diabet.2023.101507 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Youssef Kouidrat Lauriane Le Collen Martine Vaxillaire Aur élie Dechaume B énédicte Toussaint Emmanuel Vaillant Souhila Amanzougarene Mehdi Derhourhi Brigitte Delemer Mustapha Azahaf Philippe Froguel Am élie Bonnefond Source Type: research
Steatotic liver disease, MASLD and risk of chronic kidney disease
Diabetes Metab. 2023 Dec 21:101506. doi: 10.1016/j.diabet.2023.101506. Online ahead of print.ABSTRACTWith the rising tide of fatty liver disease related to metabolic dysfunction worldwide, the association of this common liver disease with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the old term nonalcoholic fatty liver disease (NAFLD). In 2023, a modified Delphi process was led by three large pan-national liver associations. There was consensus to change the fatty liver disease nomenclatur...
Source: Diabetes and Metabolism - December 23, 2023 Category: Endocrinology Authors: Josh Bilson Alessandro Mantovani Christopher D Byrne Giovanni Targher Source Type: research
Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: a nationwide cohort study
CONCLUSIONS: In this nationwide prospective study, new-onset type 1 diabetes in adulthood was significantly associated with a higher risk of mental disorders than in the general population without diabetes.PMID:38103865 | DOI:10.1016/j.diabet.2023.101505 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 16, 2023 Category: Endocrinology Authors: Seohyun Kim Gyuri Kim So Hyun Cho Rosa Oh Ji Yoon Kim You-Bin Lee Sang-Man Jin Kyu Yeon Hur Jae Hyeon Kim Source Type: research
Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: a nationwide cohort study
CONCLUSIONS: In this nationwide prospective study, new-onset type 1 diabetes in adulthood was significantly associated with a higher risk of mental disorders than in the general population without diabetes.PMID:38103865 | DOI:10.1016/j.diabet.2023.101505 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 16, 2023 Category: Endocrinology Authors: Seohyun Kim Gyuri Kim So Hyun Cho Rosa Oh Ji Yoon Kim You-Bin Lee Sang-Man Jin Kyu Yeon Hur Jae Hyeon Kim Source Type: research
Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: a nationwide cohort study
CONCLUSIONS: In this nationwide prospective study, new-onset type 1 diabetes in adulthood was significantly associated with a higher risk of mental disorders than in the general population without diabetes.PMID:38103865 | DOI:10.1016/j.diabet.2023.101505 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 16, 2023 Category: Endocrinology Authors: Seohyun Kim Gyuri Kim So Hyun Cho Rosa Oh Ji Yoon Kim You-Bin Lee Sang-Man Jin Kyu Yeon Hur Jae Hyeon Kim Source Type: research
Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: a nationwide cohort study
CONCLUSIONS: In this nationwide prospective study, new-onset type 1 diabetes in adulthood was significantly associated with a higher risk of mental disorders than in the general population without diabetes.PMID:38103865 | DOI:10.1016/j.diabet.2023.101505 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 16, 2023 Category: Endocrinology Authors: Seohyun Kim Gyuri Kim So Hyun Cho Rosa Oh Ji Yoon Kim You-Bin Lee Sang-Man Jin Kyu Yeon Hur Jae Hyeon Kim Source Type: research
Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: a nationwide cohort study
CONCLUSIONS: In this nationwide prospective study, new-onset type 1 diabetes in adulthood was significantly associated with a higher risk of mental disorders than in the general population without diabetes.PMID:38103865 | DOI:10.1016/j.diabet.2023.101505 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 16, 2023 Category: Endocrinology Authors: Seohyun Kim Gyuri Kim So Hyun Cho Rosa Oh Ji Yoon Kim You-Bin Lee Sang-Man Jin Kyu Yeon Hur Jae Hyeon Kim Source Type: research
Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: a nationwide cohort study
CONCLUSIONS: In this nationwide prospective study, new-onset type 1 diabetes in adulthood was significantly associated with a higher risk of mental disorders than in the general population without diabetes.PMID:38103865 | DOI:10.1016/j.diabet.2023.101505 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 16, 2023 Category: Endocrinology Authors: Seohyun Kim Gyuri Kim So Hyun Cho Rosa Oh Ji Yoon Kim You-Bin Lee Sang-Man Jin Kyu Yeon Hur Jae Hyeon Kim Source Type: research
Metformin treatment is associated with improved survival in diabetic patients hospitalized with acute heart failure: A prospective observational study using the Korean acute heart failure registry data
CONCLUSIONS: Metformin treatment at the time of admission was associated with a lower risk for 1-year mortality in patients with diabetes, hospitalized for acute HF.PMID:38097010 | DOI:10.1016/j.diabet.2023.101504 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 14, 2023 Category: Endocrinology Authors: Kyeong-Hyeon Chun Jaewon Oh Chan Joo Lee Jin Joo Park Sang Eun Lee Min-Seok Kim Hyun-Jai Cho Jin-Oh Choi Hae-Young Lee Kyung-Kuk Hwang Kye Hun Kim Byung-Su Yoo Dong-Ju Choi Sang Hong Baek Eun-Seok Jeon Jae-Joong Kim Myeong-Chan Cho Shung Chull Chae Byung- Source Type: research
