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Anti-IgLON 5 Disease
AbstractPurpose of reviewThis review aims to give an overview about the current knowledge of this novel neurological disorder associated to IgLON-5 antibodies and its treatment.Recent findingsAnti-IgLON5 disease was first formally described in 2014. This newly discovered disorder recaps a complex neurological disorder with sleep, movement, and neuroimmunological and neurodegenerative aspects.SummaryThe clinical manifestation of the anti-IgLON5 disease is very heterogeneous mostly including a sleep disorder with non-rapid eye movement (REM) sleep parasomnia and REM behavior disorder besides obstructive sleep apnea syndrome ...
Source: Current Treatment Options in Neurology - June 23, 2018 Category: Neurology Source Type: research

Management of Subdural Hematomas: Part I. Medical Management of Subdural Hematomas
AbstractPurpose of reviewSubdural hematomas (SDH) represent common neurosurgical problem associated with significant morbidity, mortality, and high recurrence rates. SDH incidence increases with age; numbers of patients affected by SDH continue to rise with our aging population and increasing number of people taking antiplatelet agents or anticoagulation. Medical and surgical SDH management remains a subject of investigation.Recent findingsInitial management of patients with concern for altered mental status with or without trauma starts with Emergency Neurological Life Support (ENLS) guidelines, with a focus on maintainin...
Source: Current Treatment Options in Neurology - June 23, 2018 Category: Neurology Source Type: research

Antiplatelet Agents in Secondary Stroke Prevention: Selection, Timing, and Dose
AbstractPurpose of reviewThis narrative review critically evaluated the published studies regarding the systematic use of antiplatelet agents for secondary stroke prevention.Recent findingsStroke is a leading cause of morbidity and mortality around the world. Multimodal prevention is the most viable strategy for reducing the societal burden of stroke recurrence. For secondary stroke prevention, antiplatelet therapy is at the core of effective long-term vascular risk reduction among survivors of an ischemic stroke or transient ischemic attack (TIA). In addition to aspirin, there are several antiplatelet agents proven to be ...
Source: Current Treatment Options in Neurology - June 23, 2018 Category: Neurology Source Type: research

Treatment of Visual Disorders in Parkinson Disease
This article discusses visual disorders in both Parkinson disease (PD) and other Parkinsonian disorders. It is organized largely by the anatomical site of pathology and emphasizes practical treatments. Targeted treatment options include medications, surgery, occupational, and physical therapies as well as optical aids.Recent findingsThe causes of visual complaints in Parkinson disease and other similar disorders are being more clearly identified. A new medication approved specifically to treat hallucinations in PD now is available. There is increased understanding of the important role that an ophthalmologist can play in t...
Source: Current Treatment Options in Neurology - June 23, 2018 Category: Neurology Source Type: research

Current and Emerging Therapies for Duchenne Muscular Dystrophy
AbstractPurpose of reviewThe purpose of this review is to summarize the current and emerging therapies for Duchenne muscular dystrophy (DMD).Recent findingsCoinciding with new standardized care guidelines, there are a growing number of therapeutic options to treat males with DMD. Treatment of the underlying pathobiology, such as micro-dystrophin gene replacement, exon skipping, stop codon read-through agents, and utrophin modulators showed variable success in animal and human studies. Symptomatic therapies to target muscle ischemia, enhance muscle regeneration, prevent muscle fibrosis, inhibit myostatin, and reduce inflamm...
Source: Current Treatment Options in Neurology - June 23, 2018 Category: Neurology Source Type: research